DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Fgd6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_036011484.1	Gene:	Fgd6 / 13998	MGIID:	1261419	Length:	1401	Species:	Mus musculus

Alignment Length:	952	Identity:	196/952 - (20%)
Similarity:	340/952 - (35%)	Gaps:	265/952 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PPDHKAA-------QPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNI 92
            ||:|.|:       .|.:|..:..:                |..:.|  |:..|:     ..|.:
Mouse   523 PPNHGASASPFDMPNPTSEKPVWKL----------------PHPILP--FSGSPE-----ALKRV 564

  Fly    93 KLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF----NLQL- 152
            .|.|    ||         ||::  .||......::.....:|.|..:..|....|    |::|
Mouse   565 TLSL----NN---------EPSV--SLTKPRAKSLSAVDADRCNKPCKDPPKKTSFKKLINVKLS 614

  Fly   153 -----SPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIE-- 210
                 |..::..|....:.|:.:.....|:...:::.....|...::.|:........:.::|
Mouse   615 IGFIKSDFQKIRSKSCQHGDVSAGHPLAREPKGLESDWQGLATGEEKRSKPTKAHSAENCSLESQ 679

  Fly   211 -----------NG--TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLA 262
                       ||  .|.:||.|   ||.....|.|...|...|.          |..|:.....
Mouse   680 KVKSWGQSSAVNGQRAESLDDRI---LSRHTSCTGDFGPEYENVR----------HYEEIPEYEN 731

  Fly   263 LDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLV-----STSSSSSSL 322
            |..|.:..:        ||:...:.|.|.....|....|......|.|:|.     ...||.:|
Mouse   732 LPFVMAGRN--------TPDLGWQNSSSVEDTDASLYEVEEPYNAPDGQLQLDPRHQPCSSGTS- 787

  Fly   323 LVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACN 387
                    |....|::...|.:.|.|.   .|.|.|::.|..:      .:|.:|:...|
Mouse   788 --------QEGKDALHLGLSDLPSDEE---VINSSDEDDVSSE------SSKGEPDPLED----- 830

  Fly   388 GTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMG 452
                     |::|.......:|                 ::.:|::.:|..::|||..|...|.|
Mouse   831 ---------KQDEDAGMKSKVH-----------------HIAKEIMSSEKVFVDVLKLLHIDFRG 869

  Fly   453 PL-------------ERHLNQDELRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLDF 503
            .:             :|.|||     |...:.:|.:::...|.:|.| .||...:.::|.:|:.
Mouse   870 AVAHASRQLGKPVIEDRILNQ-----ILYYLPQLYELNRDLLKELEERMLTWTEQQRIADIFVK- 928

  Fly   504 REPFL-IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYH 567
            :.|:| :|..:.......:..|.:.||||.....:|::.|.......|.|:..|..|:|||.:|.
Mouse   929 KGPYLKMYSTYIKEFDKNVALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYR 993

  Fly   568 LLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIH-LLQNGN 631
            |||...:|.......|:|..:.|...:|:|:.:.|:..:..|:...:.:::.|:...| ::|.|.
Mouse   994 LLLTDYLKNLLEDSVDHRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLSGHHEIVQPGR 1058

  Fly   632 GSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQ---YTYRDSHNLA 693
            ....|:.|.|:   :|..|..:.     |..|:|:..|:.       |..||   |...:..:||
Mouse  1059 NDVFLKEGTLM---KLSRKVMQP-----RMFFLFNDALLY-------TTPMQSGMYKLNNMLSLA 1108

  Fly   694 DYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAME--------- 749
            ..:|.         :.|:..||..|..:|.:.:|.|...|..|||.|.:|::.::|
Mouse  1109 GMKVR---------KPTQEAYQNELKIESVERSFILSASSAAERDDWLEAISSSIEEYAKKRITF 1164

  Fly   750 ----SLEPPGCQSTDHKMEIYTFDA----------PTTCRHC-SKF-LKGRIHQGYRCKVCQISV 798
                ||:    :.::.|.|:....|          .|.|..| |:| |..|.|   .|:.|...|
Mouse  1165 CPSRSLD----EDSERKEEVSPLGAKAPIWIPDTRATMCMICTSEFTLTWRRH---HCRACGKIV 1222

  Fly   799 HKGCISS-------TGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRV 856
            .:.|.|:       .|:..:        ||:....|..    .:|     |:| :.|:|:
Mouse  1223 CQACSSNKYGLDYLKGQLAR--------VCEHCFQELQ----KLD-----HQL-SPRVGS----- 1264

  Fly   857 RP---QGPSTA-----HETMYALSLKTDDNVIKHMKINQENS 890
             |   :.||:|     |........|.....:|.:..|.|:|
Mouse  1265 -PGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDS 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	19/103 (18%)
		RhoGEF	428..603	CDD:279015	48/189 (25%)
		PH_Vav	624..753	CDD:269930	35/145 (24%)
		PH	641..749	CDD:278594	27/110 (25%)
		C1_1	761..804	CDD:278556	15/54 (28%)
		SH2_Vav_family	824..934	CDD:198193	16/75 (21%)
		SH3	940..993	CDD:302595
Fgd6	XP_036011484.1	RhoGEF	845..1028	CDD:395496	48/188 (26%)
		PH-like	1047..1171	CDD:418428	34/147 (23%)
		FYVE_FGD6	1188..1248	CDD:277282	16/70 (23%)
		PH2_FGD5_FGD6	1307..1395	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910