DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and IQGAP3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_024309041.1	Gene:	IQGAP3 / 128239	HGNCID:	20669	Length:	1643	Species:	Homo sapiens

Alignment Length:	860	Identity:	154/860 - (17%)
Similarity:	268/860 - (31%)	Gaps:	308/860 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRC--KVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL------DPREFNR 79
            |...|:..|  :.:|...:          |..:||:||||..|.....||.:      |..:...
Human    44 EAKRWMEACLKEELPSPVE----------LEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRY 98

  Fly    80 KPQMAQFLCSKNIKLFLD-VCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHP 143
            :.....|..:.||..:|. :.|  .|:......|.|.:||..|..||:..:..||
Human    99 QATGLHFRHTDNINFWLSAIAH--IGLPSTFFPETTDIYDKKNMPRVVYCIHALS---------- 151

  Fly   144 DLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDIT 208
             |..|.|.|:|            .:|                    :.|.:..
Human   152 -LFLFRLGLAP------------QIH--------------------DLYGKVK------------ 171

  Fly   209 IENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFD--------LALD- 264
                      :..:.||||.     ::....|::.|..|...|....|||.|        ||::
Human   172 ----------FTAEELSNMA-----SELAKYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINE 221

  Fly   265 -----VVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSA--------------------- 303
                 ||..|.....|     |.:.....:.||||....:...|
Human   222 AVERGVVEDTLAALQN-----PSALLENLREPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYD 281

  Fly   304 ---APGPPMGRLVSTSSSSSSLLVS----------ESQRLQRAAAAVYNYRSSMASTEHEYAYIY 355
               ......|.:...:....|..:.          |.|..:....|:.:...::.....::|..|
Human   282 HYLTQAEIQGNINHVNGKDQSPRIHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWY 346

  Fly   356 SE----DDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQT 416
            .|    |.|:..::|..|  :...|.||.....|.|..|     .:|:.:...:..:::..|.:.
Human   347 LEQLNSDREQKAQELGLV--ELLEKEEVQAGVAAANTKG-----DQEQAMLHAVQRINKAIRRRV 404

  Fly   417 ASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPL------ERHLNQDELRLIFPRIRELVD 475
            |:.|        ::||:..|:....|.....:.:...|      :..|.|:||.:....:..:|.
Human   405 AADT--------VKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGELGQEELFVAVEMLSAVVL 461

  Fly   476 IH--------TKFLDKLRESLTPNAKV--KMAQVFLD----------FREPFLIYGEFCSLLLGA 520
            |:        :.|...|....|..|:|  :.||.:.|          ..|.||.:.
Human   462 INRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQERGMGEDFLSWN--------- 517

  Fly   521 IDYLADVCKKN-------------QIIDQLVQKCERDYNVGKLQL----RDILSVPMQRILKYHL 568
             |..|.|.:.|             .:|::.:.|...:..:..|.|    .|.:|:|:..  :|||
Human   518 -DLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAP--RYHL 579

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGS 633
            ||....::.:                        :|..|...::.:::::..:
Human   580 LLVAAKRQKA------------------------QVTGDPGAVLWLEEIRQGV------------ 608

  Fly   634 DLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALH--IKTGDMQYTYR--------- 687
                           ::|::|..|..|.|       :.|.|::  ||.|....|.|
Human   609 ---------------VRANQDTNTAQRMA-------LGVAAINQAIKEGKAAQTERVLRNPAVAL 651

  Fly   688 -----DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEA 747
                 |..|.....:|.:.:::....||.|..|..:  |.| ||:..:|::  .:..|.
Human   652 RGVVPDCANGYQRALESAMAKKQRPADTAFWVQHDM--KDG-TAYYFHLQT--FQGIWE------ 705

  Fly   748 MESLEPPGCQ-STDH 761
                :||||. :|.|
Human   706 ----QPPGCPLNTSH 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	28/117 (24%)
		RhoGEF	428..603	CDD:279015	38/217 (18%)
		PH_Vav	624..753	CDD:269930	25/144 (17%)
		PH	641..749	CDD:278594	25/123 (20%)
		C1_1	761..804	CDD:278556	1/1 (100%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
IQGAP3	XP_024309041.1	RasGAP_C	16..>209	CDD:332048	48/246 (20%)
		Myosin_head	<746..>969	CDD:332202
		RasGAP_C	<873..1643	CDD:332048
		RasGAP_IQGAP3	999..1348	CDD:213346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910