DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and AgaP_AGAP012252

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_320290.4	Gene:	AgaP_AGAP012252 / 1280437	VectorBaseID:	AGAP012252	Length:	684	Species:	Anopheles gambiae

Alignment Length:	236	Identity:	59/236 - (25%)
Similarity:	110/236 - (46%)	Gaps:	46/236 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   759 TDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPV-CD 822
            |.|:.:.:|:.:||.|.||...|.|.||||.:|..|.::|||       ||::   |||... ||
Mosquito   118 TKHEFKEWTYSSPTFCDHCGSLLYGLIHQGLKCTACDMNVHK-------RCEE---SVPNLCGCD 172

  Fly   823 R-------QLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTD-DNV 879
            .       ||: ..:.||.::.|.        :.|..|:.:.|.|.|   :....:.|..| |||
Mosquito   173 HTERRGRIQLT-ITYAAGKLNIEV--------KQGRNLIPMDPNGSS---DPYVKIKLIPDADNV 225

  Fly   880 IKHMKINQENS----GDSMLYCLSSR-RHFKTIVELVSY--YERND-LGENFAGLNQSLQWP--- 933
            .|..|..:.:.    .:::::.|... :..:.::|:..:  ..||| :|....|:::.|:.|
Mosquito   226 KKKTKTIRASLNPVWNETLIFDLKPEDKDRRLLIEVWDWDRTSRNDFMGSLSFGISEILKNPVDG 290

  Fly   934 YKEVIATALYDY----EPKAGSNQLQLRTDCQVLVIGKDGD 970
            :.:::.....:|    .|:.|::.:||::..:.:.:..|.|
Mosquito   291 WFKLLTQEEGEYYNVPVPEEGADLVQLKSQMRKIPMMGDKD 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	18/42 (43%)
		SH2_Vav_family	824..934	CDD:198193	26/121 (21%)
		SH3	940..993	CDD:302595	7/35 (20%)
AgaP_AGAP012252	XP_320290.4	C1_1	46..107	CDD:278556
		C1_1	120..172	CDD:278556	23/61 (38%)
		C2_PKC_alpha_gamma	177..306	CDD:175992	27/140 (19%)
		S_TKc	347..613	CDD:214567
		STKc_cPKC	350..677	CDD:270739
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910