Protein Alignment Vav and Vav

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_061511517.1
• Gene: Vav / 1279719
• VectorBaseID: AGAMI1_010207
• Length: 812
• Species: Anopheles gambiae
• Alignment Length: 974
• Identity: 503/974 - (51%)
• Similarity: 637/974 - (65%)
• Gaps: 182/974 - (18%)

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||||.||||||.:||.||:|...|::|::||..||||||||||....||||.|.::|||||||
Mosquito    14 ELWRECAAWLTRCNIIPNDHRANHLDSDIKVLATILRDGVLLCNLANFFDPSSFDRKDFNRKPQM 78

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            |.|||.:||||||:.|..|||:::|||||||||||||||||||:||||||.|||||.. .::.||
Mosquito    79 AHFLCIQNIKLFLEACKTNFGLKEADLFEPTMLYDLTNFHRVLLTLSKLSTCRKVQTA-TNIPGF 142

  Fly   149 NLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
            ......|||:..|:.||||||::.      |.:|:....               :|.:|.:
Mosquito   143 ITHSVQTERTSLDDDIYKDLHASQ------SLLDSELRC---------------DNKEIVL---- 182

  Fly   214 EDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVT 278
                  |.|||                       .|:.   :|.||           .|..|.::
Mosquito   183 ------INDSL-----------------------PCRN---QETSF-----------YGHCNELS 204

  Fly   279 PTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSS 343
            ..|:..||
Mosquito   205 SFPDCSAR--------------------------------------------------------- 212

  Fly   344 MASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
                          ::||:|||||||||.:      |...:|
Mosquito   213 --------------EEEKIYEDLCYVTFSS------TLPQLA----------------------- 234

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIREL 473
                    :||.:.||||:||:||:|||.|||:.|.|||..||.|||:.|:::|:|.|||.||||
Mosquito   235 --------SSSNNLEQRDFVIKELLDTEKNYLEALNALKYIFMQPLEKLLSKEEIRAIFPCIREL 291

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
            |:||.||||:|.|::.|.:|:|::..||:||||||||||:||.:..|::.|.:.|||:..::|.|
Mosquito   292 VEIHNKFLDRLHEAVCPGSKLKLSTTFLEFREPFLIYGEYCSSMTSAVETLREACKKSNTVEQTV 356

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE 603
            .:.:::::.|:|||||||||||||||||||||||||:||.|.|||:|.||||||||:||:||.||
Mosquito   357 LQSQKEHSDGRLQLRDILSVPMQRILKYHLLLDKLVQETVPTHDDFRGLERAKEAMVDVAQYSNE 421

  Fly   604 VKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKI 668
            |||||:||::|||||:||.|::|   .||::|.|||||||||:|:||||||||.|.||||||:|:
Mosquito   422 VKRDSEHLIVIQKVKESISDLNL---PNGNNLEQYGRLLLDGDLNIKAHEDQKMKHRYAFVFEKV 483

  Fly   669 LIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKS 733
            :|:||..:.|.|:.||::|::|||.|||:|..:||||:|||.|.||.||||||:..||||||:|:
Mosquito   484 MILVKNSNTKIGEAQYSFREAHNLLDYRIEILNSRRTLGRDGRLKYSLLLARKTQATAFTLYMKT 548

  Fly   734 EHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISV 798
            |.||:||::|...|||:|||.||::||||..|:|||.|..||||||||||:||||||||||:|.|
Mosquito   549 EEEREKWKRAFETAMETLEPVGCKNTDHKFVIHTFDTPVICRHCSKFLKGKIHQGYRCKVCEIVV 613

  Fly   799 HKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPST 863
            |:|||||||||||.. ..|||||||.|||||||.|.|:|::|..||||::||||||||||||.|.
Mosquito   614 HRGCISSTGRCKQLQ-QTPPPVCDRLLSEFNWFVGTMNRDSATQRLENKKIGTYLLRVRPQGASH 677

  Fly   864 AHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQ 928
            ..||:||||||||..:||||||.|:....::.|.||:||:||||:||||:|||||||||||||||
Mosquito   678 ESETIYALSLKTDKKIIKHMKIYQKKEHQNVFYYLSTRRYFKTIIELVSFYERNDLGENFAGLNQ 742

  Fly   929 SLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQ 992
            .||||:||.|..|:||:.|.. .|||.:|..|||:||||:||||||||||..:.||:||||||:
Mosquito   743 LLQWPFKEEIVVAIYDFAPNE-LNQLPMRQGCQVIVIGKEGDSKGWWRGKTLEKVGFFPKEYVR 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	81/115 (70%)
		RhoGEF	428..602	CDD:459876	107/173 (62%)
		PH_Vav	624..753	CDD:269930	78/128 (61%)
		C1_VAV	759..810	CDD:410360	40/50 (80%)
		SH2_Vav_family	824..934	CDD:198193	76/109 (70%)
		SH3	940..993	CDD:473055	33/53 (62%)
Vav	XP_061511517.1	None