DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and AgaP_AGAP010292

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_319489.4	Gene:	AgaP_AGAP010292 / 1279719	VectorBaseID:	AGAP010292	Length:	762	Species:	Anopheles gambiae

Alignment Length:	961	Identity:	484/961 - (50%)
Similarity:	606/961 - (63%)	Gaps:	218/961 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||||.||||||.:||.||:|...|::|::||..||||||||||....||||.|.::|||||||
Mosquito    14 ELWRECAAWLTRCNIIPNDHRANHLDSDIKVLATILRDGVLLCNLANFFDPSSFDRKDFNRKPQM 78

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            |.|||.:||||||:.|..|||:::|||||||||||||||||||:||||||.|||||.. .::.||
Mosquito    79 AHFLCIQNIKLFLEACKTNFGLKEADLFEPTMLYDLTNFHRVLLTLSKLSTCRKVQTA-TNIPGF 142

  Fly   149 NLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
            ......|||:..|:.||||||             ||.|:..||
Mosquito   143 ITHSVQTERTSLDDDIYKDLH-------------ASTSNPVEY---------------------- 172

  Fly   214 EDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVT 278

Mosquito   173 ----------------------------------------------------------------- 172

  Fly   279 PTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSS 343

Mosquito   173 ----------------------------------------------------------------- 172

  Fly   344 MASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
                                                      |:   :|..:.|.||||||||::
Mosquito   173 ------------------------------------------CS---HDEHDMKVEEVYQDLCSI 192

  Fly   409 HRTSRSQ-TASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
            ...||:| ::||.:.||||:||:||:|||.|||:.|.|||..||.|||:.|:::|:|.|||.|||
Mosquito   193 QNASRNQVSSSSNNLEQRDFVIKELLDTEKNYLEALNALKYIFMQPLEKLLSKEEIRAIFPCIRE 257

  Fly   473 LVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
            ||:||.||||:|.|::.|.:|:|::..||:||||||||||:||.:..|::.|.:.|||:..::|.
Mosquito   258 LVEIHNKFLDRLHEAVCPGSKLKLSTTFLEFREPFLIYGEYCSSMTSAVETLREACKKSNTVEQT 322

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
            |.:.:::::.|:|||||||||||||||||||||||||:||.|.|||:|.||||||||:||:||.|
Mosquito   323 VLQSQKEHSDGRLQLRDILSVPMQRILKYHLLLDKLVQETVPTHDDFRGLERAKEAMVDVAQYSN 387

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDK 667
            ||||||:||::|||||:||.|::|   .||::|.|||||||||:|:||||||||.|.||||||:|
Mosquito   388 EVKRDSEHLIVIQKVKESISDLNL---PNGNNLEQYGRLLLDGDLNIKAHEDQKMKHRYAFVFEK 449

  Fly   668 ILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLK 732
            ::|:||..:.|.|:.||::|::|||.|||:|..:||||:|||.|.||.||||||:..||||||:|
Mosquito   450 VMILVKNSNTKIGEAQYSFREAHNLLDYRIEILNSRRTLGRDGRLKYSLLLARKTQATAFTLYMK 514

  Fly   733 SEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQIS 797
            :|.||:||::|...|||:|||.||::||||..|:|||.|..||||||||||:||||||||||:|.
Mosquito   515 TEEEREKWKRAFETAMETLEPVGCKNTDHKFVIHTFDTPVICRHCSKFLKGKIHQGYRCKVCEIV 579

  Fly   798 VHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPS 862
            ||:|||||||||||.. ..|||||||.|||||||.|.|:|::|..||||::||||||||||||.|
Mosquito   580 VHRGCISSTGRCKQLQ-QTPPPVCDRLLSEFNWFVGTMNRDSATQRLENKKIGTYLLRVRPQGAS 643

  Fly   863 TAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLN 927
            ...||:||||||||..:||||||.|:....::.|.||:||:||||:||||:||||||||||||||
Mosquito   644 HESETIYALSLKTDKKIIKHMKIYQKKEHQNVFYYLSTRRYFKTIIELVSFYERNDLGENFAGLN 708

  Fly   928 QSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGK 978
            |.||||:||.|..|:||:.|.. .|||.:| .|||:||||:||||||||||
Mosquito   709 QLLQWPFKEEIVVAIYDFAPNE-LNQLPMR-GCQVIVIGKEGDSKGWWRGK 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	78/111 (70%)
		RhoGEF	428..603	CDD:279015	107/174 (61%)
		PH_Vav	624..753	CDD:269930	78/128 (61%)
		PH	641..749	CDD:278594	67/107 (63%)
		C1_1	761..804	CDD:278556	32/42 (76%)
		SH2_Vav_family	824..934	CDD:198193	76/109 (70%)
		SH3	940..993	CDD:302595	25/39 (64%)
AgaP_AGAP010292	XP_319489.4	CH	14..127	CDD:278723	78/112 (70%)
		RhoGEF	213..388	CDD:279015	107/174 (61%)
		PH_Vav	405..535	CDD:269930	81/132 (61%)
		PH	440..531	CDD:278594	53/90 (59%)
		C1_1	543..586	CDD:278556	32/42 (76%)
		SH2_Vav_family	606..715	CDD:198193	76/108 (70%)
		SH3	719..>756	CDD:302595	23/38 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	230	1.000	Domainoid score	I5425
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3961
Inparanoid	1	1.050	953	1.000	Inparanoid score	I1011
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		oto107607
Panther	1	1.100	-	-	LDO	PTHR45818
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1295
TreeFam	1	0.960	-	-
	13	12.940