DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Cnn1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011240690.2	Gene:	Cnn1 / 12797	MGIID:	104979	Length:	306	Species:	Mus musculus

Alignment Length:	157	Identity:	41/157 - (26%)
Similarity:	69/157 - (43%)	Gaps:	38/157 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASSSSSN-----SFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIR--ILAMT----- 53
            :||.||::     ::|..|.|...|.::.            ||   |.:.|:|  |..:|
Mouse    47 LASMSSAHFNRGPAYGLSAEVKNKLAQKY------------DH---QREQELREWIEGVTGRRIG 96

  Fly    54 ------LRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFE 112
                  |:||::||..:..|.|.|:  ::.|...|....|  :||..|:... ..:|::..|:||
Mouse    97 NNFMDGLKDGIILCEFINKLQPGSV--KKVNESTQNWHQL--ENIGNFIKAI-TKYGVKPHDIFE 156

  Fly   113 PTMLYDLTNFHRVLITLSKLSQCRKVQ 139
            ...|::.||..:|..||..|:...|.:
Mouse   157 ANDLFENTNHTQVQSTLLALASMAKTK 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	32/124 (26%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Cnn1	XP_011240690.2	CH_CNN1	76..183	CDD:409131	33/114 (29%)
		Calponin	213..237	CDD:395325
		Calponin	253..276	CDD:395325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910