DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and AgaP_AGAP010767

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_318541.4	Gene:	AgaP_AGAP010767 / 1278895	VectorBaseID:	AGAP010767	Length:	1932	Species:	Anopheles gambiae

Alignment Length:	685	Identity:	142/685 - (20%)
Similarity:	250/685 - (36%)	Gaps:	199/685 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 LQLSPTERSHSDEAIYKDLHSTDLNMR-----------------KTSSIDASASSSAEYYDRTSQ 197
            :.::.|..:.....|.....:|:||:.                 |:.|...|.:.|..|.:|:.:
Mosquito  1051 MPITDTRTTTGSATIKSSKSNTNLNINTLIKNKLNHNKHSPASVKSKSAPVSVNRSESYKERSQK 1115

  Fly   198 S--GSLDENSDITIENGTEDIDDYIE-DSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSF 259
            .  .:..:.||.::   |:..|:..| .||:|      :|.:..:....||..|.:.:.:..:..
Mosquito  1116 KTRTTRRKTSDPSL---TKTADEQNEASSLAN------NNYSSSSTSSLPLALDSRSASMEAVGG 1171

  Fly   260 DLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSV---------------PV-SAAPGPP 308
            .....|.|:...|..:.:.||       ..||.....||.               || |...|.|
Mosquito  1172 GATTAVSSAGPAGTVSGINPT-------HSSPGGVGLPSSASTTSGGTGGGLHGGPVGSGGSGGP 1229

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQA 373
            .|..|.|:..                                  :|.|:|:..|
Mosquito  1230 GGLNVPTARE----------------------------------WIDSDDEGTV----------- 1249

  Fly   374 KAKPEVT-TDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTES 437
              :||.. :.|||             .|:...:..|.:             :|..||.|:..||.
Mosquito  1250 --EPEADWSSNIA-------------PEILSSIGDLEK-------------KRQEVINEIYQTER 1286

  Fly   438 NYLDVLTALKTKFMGPLERH--LNQDELRLIFPR-IRELVDIHTKFLDKLRESLTPNAKV--KMA 497
            |::..|..|:..||.||:..  |..|.|.|:||. :..|.|:||.|..||::..:.:..:  ::.
Mosquito  1287 NHVRTLRLLEGIFMRPLQESGALPHDLLNLLFPHSLIHLKDLHTAFELKLKQRRSEHGNIVREIG 1351

  Fly   498 QVFL---------DFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLR 553
            .:.|         :.:|.   ...||:....|::.|.:..||::.:.:::.|.|......:|||:
Mosquito  1352 DLLLTMFDGQTGEELKEH---AAHFCARQQIALEALKERRKKDEQLQRILTKAESHKACRRLQLK 1413

  Fly   554 DILSVPMQRILKYHLLLDKL----VKETSPLHDDYRSLERAKEAMIDVSQYINEVKR---DSDHL 611
            |:|...:||:.||.||.|.|    |:.|.....:..::.::.|:...:..::|:..|   |...|
Mosquito  1414 DLLPTALQRLTKYPLLFDNLYNFTVRSTPKNEGEALAIRKSHESAKRILDHVNQAVRTEEDMHKL 1478

  Fly   612 VIIQKVKDSICDIHLLQNGNGSDL----------LQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            ..||:..|.          :|.|.          |...:|:.||.|.:|.:...:.   :..:|:
Mosquito  1479 ATIQRKLDK----------SGLDKEAAVEFKNIDLTVRKLIHDGPLTMKKNPGVQL---HGLLFE 1530

  Fly   667 KILIMVKALHIKTGDMQY--TYRDSHNLADYRVEQSHSRRTIGR-DTRFKYQLLLARKSGKTAFT 728
            .|:::     ::..|.:|  .|..|..|..     |.|:...|| :...|..|:|.|:|.....|
Mosquito  1531 DIMVL-----LQKQDDKYLVKYHSSPGLGG-----SESKYAEGRFNPITKIHLILVRQSAVDKNT 1585

  Fly   729 LYL-------------KSEHERDKWRKALTEAMES 750
            .:|             .|..|...|.|.:::|.|:
Mosquito  1586 FFLINTNVSQMLELTAPSSTECKTWFKHISDAAEA 1620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	51/192 (27%)
		PH_Vav	624..753	CDD:269930	32/153 (21%)
		PH	641..749	CDD:278594	28/123 (23%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
AgaP_AGAP010767	XP_318541.4	PDZ	24..103	CDD:214570
		RGS-like	664..859	CDD:286245
		C1_1	903..947	CDD:278556
		RhoGEF	1277..1467	CDD:279015	51/192 (27%)
		PH_RhoGEF	1508..1618	CDD:275411	27/122 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910