DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and AgaP_AGAP007717

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_564508.3	Gene:	AgaP_AGAP007717 / 1269515	VectorBaseID:	AGAP007717	Length:	1776	Species:	Anopheles gambiae

Alignment Length:	1101	Identity:	198/1101 - (17%)
Similarity:	374/1101 - (33%)	Gaps:	335/1101 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVC 99
            ||..|:::.::.::|:                   |.:....|||:..:.:...:.:
Mosquito   204 PPSRKSSRSNSTLKIM-------------------SQVKTNTFNRRTMLERTTTTTS-------- 241

  Fly   100 HNNFGIRDADLFEP----TMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHS 160
             ::.|::....|..    .:.|........::|.:.|.:..|.|:
Mosquito   242 -SSSGMKQPSKFRSKSAGPLFYGGATSSSSIVTSASLMKEEKNQE-------------------- 285

  Fly   161 DEAIYKDLHSTDL-NMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSL 224
                    :||.: :.|.|:....::|||.....|.:....:.....|:.|....:....||:.|
Mosquito   286 --------NSTRVASKRYTAGSYRTSSSSPTGQQRKASQSPVAFGRGISKERTFAEEKKRIEEKL 342

  Fly   225 SNMCDSTID----------NDAEDA--GVETPLLSDCQGSHVREL--SFDLALDVVSSTTDGAS- 274
            ..:...:..          |:.:.|  ....|::....|||..:|  ||:.....|.:||...:
Mosquito   343 PKIVSVSTSILRNPELKSPNEVKKALRSSYLPIVGRKNGSHHHQLKKSFNRKSSTVRTTTPSITI 407

  Fly   275 -------------NAVTPTPESYARQ------------------SQSPLAAAAP--SVPVSAAP- 305
                         .|.|.:.:|.||.                  |..|.:...|  :.|.||..
Mosquito   408 KTSFQKASKAFGLKAKTSSNQSLARTCSTYSIDSTNSKTRRSRISDGPSSTIPPTRNHPRSAQKI 472

  Fly   306 --GPPMGRLVSTSSSSSSLLVSESQRLQ---------RAAAAVYN---YRSSMASTEHEYAYI-- 354
              |..:.|.:.|..:.|...|.:...||         |..|.::|   .||..:..:..| |:
Mosquito   473 FLGNSLDRGLKTVKTKSPTPVLQETHLQSMVQRNESMRKKARMWNSLTCRSEPSLKQSNY-YLSQ 536

  Fly   355 --------YSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDL------ 405
                    :..:|.....:|. ..:|.:::.|...:......|.   |..:||.:..|.
Mosquito   537 VKPVSSSKFKTNDRSDISELS-TAYQIRSRSEPPAEKTTTTTTS---TIIQEELIGTDTPRTIVG 597

  Fly   406 --CAL-HRTSRSQTASSTSF-EQRDYVIRELIDTESNYLDVLTALKTKFMGPLER-------HLN 459
              |.: .|||||.:.....: :.::..::::|...|  |......:.:...|.:.       :|:
Mosquito   598 RRCQIAQRTSRSPSCRRIQYLKGKEGQVKKIIRARS--LSGTNGQRGRLDKPKDELVRSHSLNLS 660

  Fly   460 QDELRLIFPRIRELVDIHTKFLDKL----RES------LTPNAKVKMAQVFLDFREPFLIYGEFC 514
            ||. .:...|.|||...:.. |::|    ||:      |.|:.:::..::
Mosquito   661 QDS-SVSRSRFRELNTFYNS-LERLGQLERETSSSSNDLRPSRRMREEEI--------------- 708

  Fly   515 SLLLGAIDYLADVCKK-------NQIIDQLVQKCERDYNVGKL---------------------- 550
                  |||  |:.|:       .:.:.||..|.::|.....|
Mosquito   709 ------IDY--DLWKRVRGQEKAERELSQLKSKLKQDQREKDLFFLPRDPEDVRWRSDLDTGLRN 765

  Fly   551 ---QLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE------VKR 606
               .:.|:..:..::.|.:.   |..:::.....|.|:.|.|. .::|||:.::.|      .||
Mosquito   766 REKSVEDLKCILNEQALNFE---DAKLRDLETRKDHYKPLWRG-SSVIDVASHLEEKYSTQGEKR 826

  Fly   607 D--------SDHLVI------IQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHE---- 653
            |        |.:|:.      ::|:|:.:.:|:  .|....|.....|  :..|::....|
Mosquito   827 DEPQSLDIISSNLLSTLSSEQMKKLKNQLSEIY--SNSAPKDPATPSR--VSSEMYHHQEEYIIN 887

  Fly   654 --DQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQL 716
              ::.::|       :.|:.|::..:.|.|         .|.|..:|:.|:..:||:..:.....
Mosquito   888 VPERASRL-------ESLLKVRSHSVLTQD---------KLKDKILEKHHTLPSIGKKKKNARPT 936

  Fly   717 LLA------------RKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTF- 768
            :||            ||.|....|...:....|.:..:...:.:|...|......|.|.:|..|
Mosquito   937 ILASEASIFSSLENTRKRGDANTTSSTQQPLSRQQTSEGANKNIEDRAPDDVPVEDIKTKIKYFE 1001

  Fly   769 -----DAPT-TCRHC------SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVC 821
                 |.|| |..|.      |:...|...|....|    |..||...|.....|:...:.....
Mosquito  1002 NKQGEDTPTVTIYHAREDSSLSEDESGTNQQAASKK----SAAKGTSGSMITLSQSFTDLKDLFG 1062

  Fly   822 DRQLSEFNWFAGNM----DRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKH 882
            :::....:.:..|.    .:.|:..::..:|   :..|.|...|.      ||..::|.:  :|.
Mosquito  1063 EKRSVSCSAYTANSSSQESKRTSVRKMSPKR---FTFRSRSSTPD------YATCIQTGE--VKK 1116

  Fly   883 MKINQEN--------SGDSMLYCLSSRRHFKTIVEL----VSYYERNDLGENFAGLNQSLQ 931
            :|...|:        |.|   ..:||.||:::..||    :..||:.|. ||.:..|||.|
Mosquito  1117 IKDKFESLDVNIWRQSED---IAVSSERHYQSDSELSRQPLGEYEKRDT-ENSSKKNQSKQ 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	12/100 (12%)
		RhoGEF	428..603	CDD:279015	37/223 (17%)
		PH_Vav	624..753	CDD:269930	25/146 (17%)
		PH	641..749	CDD:278594	20/125 (16%)
		C1_1	761..804	CDD:278556	15/55 (27%)
		SH2_Vav_family	824..934	CDD:198193	29/124 (23%)
		SH3	940..993	CDD:302595
AgaP_AGAP007717	XP_564508.3	SH3_Sorbs_1	1524..1575	CDD:212715
		SH3_Sorbs_2	1596..1648	CDD:212716
		SH3_Sorbs_3	1721..1773	CDD:212714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910