DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and CNN2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001290430.1	Gene:	CNN2 / 1265	HGNCID:	2156	Length:	330	Species:	Homo sapiens

Alignment Length:	292	Identity:	59/292 - (20%)
Similarity:	111/292 - (38%)	Gaps:	58/292 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QPDAEIR--ILAMT-----------LRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIK 93
            |.:||:|  |..:|           |:||.:||.|:..|.|.|:.  :.||..|....|  :|:.
Human    29 QKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVP--KINRSMQNWHQL--ENLS 89

  Fly    94 LFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITL-----------SKLSQC----------RK 137
            .|:... .::|:...||||...|::..|..:|.::|           |..:.|          .|
Human    90 NFIKAM-VSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKGLDLGSLAALCWYSRPLSLTQAK 153

  Fly   138 VQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEY------YDRTS 196
            .:.|... :...::.|..:..:.|:|..| .....:.::..::..||.|....|      ||..:
Human   154 TKGLQSG-VDIGVKYSEKQERNFDDATMK-AGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKN 216

  Fly   197 QSGSLDENSDITIENGTEDIDDYI----EDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVREL 257
            ......::|.|:::.||......:    ..:..::.|:.:..|..|....:..:...||::....
Human   217 HILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDNSSMSLQMGYTQGANQSGQ 281

  Fly   258 SFDLALDVV-------SSTTDGASNAVTPTPE 282
            .|.|...:.       .:..|||.:.....|:
Human   282 VFGLGRQIYDPKYCPQGTVADGAPSGTGDCPD 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	31/113 (27%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
CNN2	NP_001290430.1	Calponin	19..211	CDD:332521	42/188 (22%)
CNN2	NP_001290430.1	Calponin	227..250	CDD:306832	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910