DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and IQGAP2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_006624.3	Gene:	IQGAP2 / 10788	HGNCID:	6111	Length:	1575	Species:	Homo sapiens

Alignment Length:	1212	Identity:	230/1212 - (18%)
Similarity:	403/1212 - (33%)	Gaps:	381/1212 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRCKV--IPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL------DPREFNR 79
            |...|:..|.|  :||..:          |...||:||.|..|.....|..:      |..:...
Human    46 EAKRWMEVCLVEELPPTTE----------LEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRY 100

  Fly    80 KPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTN-------FHRVLITLSKLSQCRK 137
            |.....|..:.|...:|... .:.|:......|.|.:||..|       .|.:.:.|.||....:
Human   101 KKSGLHFRHTDNTVQWLRAM-ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQ 164

  Fly   138 VQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTS----------SIDASASSSAEYY 192
            :|    ||:|   ::..||...|:  :.|:|....:.|...|          |:|.:|..:|...
Human   165 IQ----DLLG---KVDFTEEEISN--MRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIA 220

  Fly   193 DRTSQSGSLDENSDITIENGTED---IDDYI--------------EDSLSNMCDSTIDNDAEDAG 240
            ...:....:.|.:.:|:.|....   :||.:              ::..:.:.:|.|..:..||.
Human   221 INEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAY 285

  Fly   241 VETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTP--TPESYARQSQSPLAAAAPSVPVSA 303
            .|....::.|| ::.:::...|:|.:        |||.|  .||:.....:.|.|......|.:|
Human   286 EELLTQAEIQG-NINKVNRQAAVDHI--------NAVIPEGDPENTLLALKKPEAQLPAVYPFAA 341

  Fly   304 A----------PGPPMGRL----------------VSTSSSSSSLLVSESQRLQRAA-------- 334
            |          ....|..|                :...:..|:.|||...:|:..|
Human   342 AMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDK 406

  Fly   335 AAVYNYRSSMASTEHEY---------------------AYIYSEDDEKVYEDLCYVTFQA--KAK 376
            |.|..|.:::.|.:.|.                     |.|..|:|..|  .:.|:. :|  :..
Human   407 AYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVV--AVGYIN-EAIDEGN 468

  Fly   377 PEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYV--IRELIDTESN- 438
            |..|.:.:..........:....:.|||:  |:.....:...|.|..:..::  |::.:| ::|
Human   469 PLRTLETLLLPTANISDVDPAHAQHYQDV--LYHAKSQKLGDSESVSKVLWLDEIQQAVD-DANV 530

  Fly   439 -----------YLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNA 492
                       .:||...|:.|        .:.|.|.::........||..:..||..::|....
Human   531 DKDRAKQWVTLVVDVNQCLEGK--------KSSDILSVLKSSTSNANDIIPECADKYYDALVKAK 587

  Fly   493 KVKMAQVFLDFREPFLIYGEFCSL-LLGAIDY------------LADVC--KKNQIIDQLVQKCE 542
            ::|..:|..|        |.:..| |....||            ..:.|  |::.:..:.::...
Human   588 ELKSERVSSD--------GSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDII 644

  Fly   543 RDYNVGKLQLRDILSVPMQRILKYH------LLLDKLVKETSPLHDD----------YRSLERAK 591
            .:..||.:: .:|.|...:.:|::.      :|.::.....|.||:.          ::..::.|
Human   645 EEVTVGYIR-ENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRK 708

  Fly   592 EAM-------------IDVSQYINEVKRDSDHLVIIQKVKD---SICDIHLLQNGN--------- 631
            |.|             :.:..:.........:|..:|..:|   .|..|..|...|
Human   709 EYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTL 773

  Fly   632 -GSD------------LLQYGRLLLDGELHI-KAHEDQKTKLRYAFVFDKILIMVKALHIKTGDM 682
             ||:            ||....|....||.: :..|:..||:|.....:|.|   ..:.||.|.:
Human   774 VGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDL---NLMDIKIGLL 835

  Fly   683 ---QYTYRD--SH---------------NLADYRVEQSHSRRTIGRDTRFKYQ----------LL 717
               :.|..|  ||               |..|.:..:|.|:..  |.|...||          |.
Human   836 VKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKER--RKTLETYQQLFYLLQTNPLY 898

  Fly   718 LAR--------KSGK----TAFTLYLKSEHERDKW------RKALTEAMESLEPPGCQSTDHKME 764
            ||:        ||.|    ..||||..:.::|:::      :.||.|.::|       ..|...:
Human   899 LAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKS-------KVDQVQD 956

  Fly   765 IYTFDAPTTCRHCSKFLKG-----RIHQGYRCKVCQISVHKGCISSTGRCKQNPVSV-------- 816
            |.|.: ||..:....|.:|     .:.|.....|.:|...|..|.:|     |||.|
Human   957 IVTGN-PTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINT-----NPVEVYKAWVNQL 1015

  Fly   817 ----------PPPVCDRQLSEFNWFAGNMDRETAAHRLEN-RRIGTYLLR-------VRPQG--- 860
                      |..|...|...:......::..     :|| ||:...:|.       :.|.|
Human  1016 ETQTGEASKLPYDVTTEQALTYPEVKNKLEAS-----IENLRRVTDKVLNSIISSLDLLPYGLRY 1075

  Fly   861 -----PSTAHETMYALS----LKTDDNVIKHMKIN------------------QENSGDSMLYCL 898
                 .::.||.....:    ||...|::.:..:|                  |.||
Human  1076 IAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINS-------- 1132

  Fly   899 SSRRHFKTIVELVSYYERNDL--GEN--FAGLNQSLQWPYKE 936
            ..||:..::.:::.:...|.|  |||  .:.:|..|...|:|
Human  1133 DQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQE 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	27/123 (22%)
		RhoGEF	428..603	CDD:279015	36/232 (16%)
		PH_Vav	624..753	CDD:269930	46/199 (23%)
		PH	641..749	CDD:278594	38/156 (24%)
		C1_1	761..804	CDD:278556	10/47 (21%)
		SH2_Vav_family	824..934	CDD:198193	26/151 (17%)
		SH3	940..993	CDD:302595
IQGAP2	NP_006624.3	CH_IQGAP2	11..166	CDD:409124	29/130 (22%)
		IQ	689..710	CDD:197470	1/20 (5%)
		IQG1	<784..1575	CDD:227586	88/422 (21%)
		RasGAP	916..1274	CDD:413381	56/285 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910