DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and UNC13B

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001358118.1	Gene:	UNC13B / 10497	HGNCID:	12566	Length:	4340	Species:	Homo sapiens

Alignment Length:	936	Identity:	172/936 - (18%)
Similarity:	295/936 - (31%)	Gaps:	288/936 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDL--------TNFHRV 125
            |..|:|...:.:|.     |:.|::       |....::.|.|......|:        .:|...
Human  2419 PQILEPASSSPEPG-----CAGNLQ-------NQDADKEEDKFALGSSVDMLSGFVTKVKSFSGS 2471

  Fly   126 LI----TLSKLSQCRK---------------VQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHST 171
            ||    |||.|....|               .|.|..:|  |.:..||....:..|:   .|.:|
Human  2472 LIEPPKTLSGLFSSPKSPKKNSFFSLASDVSSQPLKGEL--FGIFKSPKPEPYKQES---SLPAT 2531

  Fly   172 DLNMRKTSSIDASAS-----SSAEYYDRTSQSGSLDENSDITIENGTEDI--DD-----YIEDSL 224
            .. ::...|.||..|     ..|.:...:|:|...|....:.......||  ||     .:||
Human  2532 SW-LQNGCSRDAVGSVPPERREAAFTALSSESTLSDCRMTVVSAKPESDILTDDPKLTTKMED-- 2593

  Fly   225 SNMCDSTIDNDAEDAGVET----PLLSDCQGSHVRELSFDLALDVVSSTTDGAS---------NA 276
                ::|.:|..|....||    ....|..|..|..||.:..:.::.:|...||         ..
Human  2594 ----NNTPENILEPQRSETINTSSFSGDDTGQGVLSLSDEGDMGILQATDTEASLEAENFALPAQ 2654

  Fly   277 VTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYN-- 339
            :.|.|...|.:...|:   .|.:|:...|.      :.|:|::..||.............::|
Human  2655 LHPDPTCIAEELPPPI---QPPLPLEPEPA------IQTASTNQDLLELHPASSLETDTMLFNDA 2710

  Fly   340 --YRSSMASTEHEYAYIYSEDDEKVYEDLCYV-------------TFQAKAK---PEVTT-DNIA 385
              .:|:...||..:::...||......:.|.:             |.|::.:   |.||| ..:.
Human  2711 SVSQSTTLETEGHFSHPLLEDPVLAARESCEIIHAQKDPPVVPQETEQSRPRFEIPNVTTWPKLR 2775

  Fly   386 CNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKF 450
            ...:..:|...........|.:.:|.  ::|...:||::                     |.|.|
Human  2776 LPSSATNHGKPLSSFFSSPLPSGNRA--AETGLMSSFKK---------------------LSTLF 2817

  Fly   451 MGPLE---------RHLNQDELRLIFPRIRELVDIHTKF------------LDKLRESLTPNAKV 494
            .|..|         ..|...::.|.||..:|...:..:.            .|:...|...|..:
Human  2818 EGSSEGKGSVLASDSKLGFGKVDLSFPWPKENKGVPEQMPTESSPPVLVTSSDQDLNSSEANKAL 2882

  Fly   495 KMAQVFLDFREPFLIYGEFCSLLLGAIDYLA---DVCKK----------NQIIDQLVQKCERDYN 546
            |.:|:.....:|..:|.:    ..|..:.|.   :||.:          .|.|....:..:...|
Human  2883 KSSQISGASAQPGKVYTQ----PSGTSEQLVASPEVCAQGLSGSGEGGNQQEISASGEHWDTKAN 2943

  Fly   547 VGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQ----------YI 601
                     ||.|.....|:.       :|.|.:.:.:..||:.:|..:..|.          .:
Human  2944 ---------LSSPACPSGKHE-------EEPSTVSEIFHQLEKQEEEAVPASTDSDLNVQQPVTL 2992

  Fly   602 NEVK-----------------------------------RDSDHLVIIQKVKDSICDIH----LL 627
            |::|                                   :|.||     :..|||...|    |.
Human  2993 NDIKEPMTNKSPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDH-----RETDSIHSCHSSHSLS 3052

  Fly   628 QNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNL 692
            ::|......|...|.:.|:...:|..:.|.....|.......::::..|..  ..|.::.:.:..
Human  3053 RDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKEDATTHPPPDLVLQKDHFL--GPQESFPEENAS 3115

  Fly   693 ADYRVEQSHSRRTIGR-----------------------------------DTRFK--------Y 714
            :.:...::|..|.:.:                                   |.|.|        .
Human  3116 SPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPLVSDL 3180

  Fly   715 QLLLARKSGKT---AFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRH 776
            .|:.:||:|.|   |....||.|..:....|...:|:  :.|..| :|.|..|::|...||.|..
Human  3181 SLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQAL--IYPISC-TTPHNFEVWTATTPTYCYE 3242

  Fly   777 CSKFLKGRIHQGYRCKVCQISVHKGC 802
            |...|.|...||.||..|.:..|:.|
Human  3243 CEGLLWGIARQGMRCSECGVKCHEKC 3268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	16/74 (22%)
		RhoGEF	428..603	CDD:279015	34/218 (16%)
		PH_Vav	624..753	CDD:269930	27/178 (15%)
		PH	641..749	CDD:278594	23/153 (15%)
		C1_1	761..804	CDD:278556	16/42 (38%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
UNC13B	NP_001358118.1	C2A_Munc13	1..127	CDD:176040
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..210
		C1	3227..3276	CDD:237996	16/42 (38%)
		C2B_Munc13	3349..3475	CDD:175993
		DUF1041	3667..3769	CDD:368829
		Membr_traf_MHD	4014..4150	CDD:371123
		C2C_Munc13	4188..4307	CDD:176041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910