Protein Alignment Vav and VAV3

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_006104.4
• Gene: VAV3 / 10451
• HGNCID: 12659
• Length: 847
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 277/1087 - (25%)
• Similarity: 434/1087 - (39%)
• Gaps: 355/1087 - (32%)

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            |::|..||..|||:|.:|:.....|::..||.|||||||||.|:.:|...|::.:|.|.:|||:|
Human     4 WKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||..|...||:|.::|||...|:|:.:|.:|:.|||:||:.       |..:...:
Human    69 FLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRT-------PIALATGI 126

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
            :..|||.|.:||.|||
Human   127 RPFPTEESINDEDIYK------------------------------------------------- 142

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
                   .|.::.|.|:..|.||       |.||
Human   143 -------GLPDLIDETLVEDEED-------LYDC------------------------------- 162

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
                                                                             
Human   163 ----------------------------------------------------------------- 162

  Fly   346 STEHEYAYIYSEDD-EKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALH 409
                    :|.||: .:|||||                             .|.||.:|..|..:
Human   163 --------VYGEDEGGEVYEDL-----------------------------MKAEEAHQPKCPEN 190

  Fly   410 RTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELV 474
                         :.|...:.|:..||..|.:.|.:::..||.||:|.|...|...:|..|.|||
Human   191 -------------DIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPELV 242

  Fly   475 DIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ 539
            .:|...:.::.:|:.......:.|||::::|..:|||::||.:..||..|..:.|..:.:...::
Human   243 KLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLE 307

  Fly   540 KCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEV 604
            :|.:..|.||..|||:|.|||||:|||||||.:|||.|:. ..:..:|:.|.:||.|::||:|||
Human   308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTD-PTEKANLKLALDAMKDLAQYVNEV 371

  Fly   605 KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKIL 669
            |||::.|..|::.:.||      :|.| ..:|.:||...|||:.|...:....:.|:.|:||..:
Human   372 KRDNETLREIKQFQLSI------ENLN-QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAV 429

  Fly   670 IMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSE 734
            |:.|    :.|| .|..::..:|..|::  :::..|...:.::.|...|....|:.....|.|::
Human   430 IVCK----RKGD-NYEMKEIIDLQQYKI--ANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTK 487

  Fly   735 HERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVH 799
            ..:.||.:....|:.::.|....|..|..:::||...|:|:.|...|:|..:|||.|..|....|
Human   488 DLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGTFYQGYLCFKCGARAH 552

  Fly   800 KGCISSTGRC---------------------KQNPVSV----------------PPPV------- 820
            |.|:.....|                     ::.|..|                |||.
Human   553 KECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPL 617

  Fly   821 ------------------------------------------CDRQLSEFN---WFAGNMDRETA 840
                                                      |..:..:::   |:||.|:|..|
Human   618 QLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQA 682

  Fly   841 AHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFK 905
            ...|.||...|||:|.|     |.....||:|:|. :|..||:||...:.    .:.::..|.||
Human   683 ETELINRVNSTYLVRHR-----TKESGEYAISIKY-NNEAKHIKILTRDG----FFHIAENRKFK 737

  Fly   906 TIVELVSYYERNDLGENFAGLNQSLQWPYKEV----------------------IATALYDYEPK 948
            :::|||.||:.:.|.|.|..|:.:||:||||.                      ||.|.||:..:
Human   738 SLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCAR 802

  Fly   949 AGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQK 995
            .......|:.|  |:.|.....:.|||||::...||:||..||:|.:
Human   803 DMRELSLLKGD--VVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	52/110 (47%)
		RhoGEF	428..603	CDD:279015	63/174 (36%)
		PH_Vav	624..753	CDD:269930	29/128 (23%)
		PH	641..749	CDD:278594	24/107 (22%)
		C1_1	761..804	CDD:278556	16/42 (38%)
		SH2_Vav_family	824..934	CDD:198193	38/112 (34%)
		SH3	940..993	CDD:302595	18/52 (35%)
VAV3	NP_006104.4	CAMSAP_CH	18..103	CDD:288798	40/84 (48%)
		RhoGEF	193..369	CDD:238091	64/176 (36%)
		PH_Vav	383..506	CDD:269930	31/136 (23%)
		PH	407..502	CDD:278594	21/101 (21%)
		C1	514..561	CDD:237996	16/46 (35%)
		Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073	560..847		70/298 (23%)
		SH3_VAV3_1	596..657	CDD:212914	3/60 (5%)
		SH2_Vav3	666..768	CDD:198270	40/111 (36%)
		SH3_VAV3_2	791..846	CDD:212911	20/56 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5144
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1723
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm41007
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	O	PTHR45818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870