DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Ect2l

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_038949113.1	Gene:	Ect2l / 103689991	RGDID:	9246970	Length:	986	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	145/722 - (20%)
Similarity:	265/722 - (36%)	Gaps:	166/722 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTD 172
            |.|:||..:    .|..:|..|.:..|.||.|.|                     .|:...:|.:
  Rat   349 AVLYEPRGV----TFEGLLHLLGRAQQGRKAQGL---------------------GIFSSGNSRE 388

  Fly   173 LNMRKTSSIDASASSSAEYYD----------RTSQSGSLDENSDITIENGTEDIDDYIEDSLSNM 227
            :::.:...|........|..|          .|.:.|.   :.|:.:..|..:....:...||.:
  Rat   389 IDLLQGYKICIKNLLWPEVRDFWEKKLGSCLTTEEEGG---HVDLFVPLGASETGIEVLSLLSQL 450

  Fly   228 CDSTIDNDAEDAGVET------PLLSDCQGSH-----VRELSFDLALDVVSSTTDGASNAVTPTP 281
            ..::.   :..|||.|      .:|||..|.|     :.....:..|...||.|:...:.:....
  Rat   451 TGTSF---SAPAGVATGSYLTQHILSDWLGPHRDGTPLSNYFIESKLQAWSSFTEFLEDTLKSVR 512

  Fly   282 ESYARQSQS-PLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSL---LVS-ESQRLQRAAAAVYNY- 340
            : .:|.|:: ..|:.|..:..|......|..:::....:.:|   |:| :.:.| .......:|
  Rat   513 KXLSRSSRTCRRASVARMIGSSCFDTLGMDSILNNQGVAQALADGLMSCQKKGLXDKPLEFLSYF 577

  Fly   341 ---RSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVY 402
               :||..:.:.|..|:.:|...|..:| .     .|.:..: .||         ..:||.....
  Rat   578 LLKKSSKKNEDFEGDYVLTERGLKETQDXL-----MKERSSI-EDN---------SQDTKSSPRQ 627

  Fly   403 QDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQD------ 461
            .:|.....|:..:.....|.|:|..|::||:.:|..|:..|..::..:..||...|:.:
  Rat   628 SNLNMEALTTLERRLQMDSVEKRTRVVKELVQSERRYVQTLGIVRDVYARPLRAALSSNRAILSA 692

  Fly   462 -ELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVK-MAQVFLDFREPFLIYGEFCSLLLGAIDYL 524
             .:.:||.....:::::.:|||.||:.|...:... :.::|:.|.....:|..|.:      :|
  Rat   693 ANIHIIFSDTLHILNLNREFLDNLRDRLQEWSPAHCVGEIFIKFGSQLNVYTNFFN------NY- 750

  Fly   525 ADVCKKNQIIDQLVQKC--------------ERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK 575
                   .::.:.::||              :|......|.|.::|..|.:|..:|..||..|..
  Rat   751 -------PVVLKTIEKCREMAPAFRAFLKRHDRTIVTKMLSLPELLLYPSRRFEEYIHLLYALRL 808

  Fly   576 ETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGR 640
            .|...|.|..:|..|.|.:.....||:::|.:.       |:::.:.||..|..|..: |.:..|
  Rat   809 HTPAGHVDRGNLTTAIEQIKKYKDYIDQIKENF-------KMREQLSDIQTLIWGCPT-LSEANR 865

  Fly   641 LLL-------------DGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKT---GDMQYTYRDS 689
            .|:             ..|.:::.:|  :|:....|:|..:|::.......|   ...:.|||.|
  Rat   866 YLIRIQDVVQLQCCEEKTEFYLRLYE--QTQDLSLFLFSDVLLVTSRSTSHTPFEKTCKTTYRFS 928

  Fly   690 HNLADYRV--EQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLY-LK------SEHERDK--WRKA 743
            .::|..||  |.....|.|                 |.||.|. ||      :|...||  |...
  Rat   929 ASVALPRVLIEDIPDSRYI-----------------KNAFVLRGLKRDWICATESPDDKFLWLSV 976

  Fly   744 LTEAMES 750
            |..|:.|
  Rat   977 LQHAIRS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	7/23 (30%)
		RhoGEF	428..603	CDD:279015	42/196 (21%)
		PH_Vav	624..753	CDD:269930	36/154 (23%)
		PH	641..749	CDD:278594	30/134 (22%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Ect2l	XP_038949113.1	F-box-like	93..130	CDD:403981
		DUF4347	302..499	CDD:405015	33/180 (18%)
		RhoGEF	653..835	CDD:395496	41/195 (21%)
		PH-like	<894..982	CDD:418428	26/104 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910