DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and Plekhg4

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_006530585.2 Gene:Plekhg4 / 102075 MGIID:2142544 Length:1235 Species:Mus musculus


Alignment Length:326 Identity:67/326 - (20%)
Similarity:131/326 - (40%) Gaps:56/326 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   428 VIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIRELVDIHTKFLDKLRESL 488
            |:.|::.||..|:..|......:...|:|......||    .:|..:.:|.|.|..|..:..|:.
Mouse   765 VLAEMVATEREYVRALDYTIQNYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHYNFFLRELEAC 829

  Fly   489 TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKC------ERDYNV 547
            |.:.. ::|..||..|..|.:|..:              .|.....|.|:...      |:...:
Mouse   830 TRHPP-RVAHAFLRHRVQFGMYALY--------------SKNKPRSDALMTNYGHTFFKEKQQAL 879

  Fly   548 G-KLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHL 611
            | .|.|...|..|:|.:.||.|||.:|.:.......:..:|: |.::::..     :::..:|.|
Mouse   880 GDHLDLASYLLKPIQHMSKYALLLQELARACGGPAQELGALQ-AAQSLVHF-----QLRHGNDLL 938

  Fly   612 VIIQKVKDSI--CDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKA 674
            .:     |:|  ||::|.:.         |:|:...|..::|  .:....|..|:|:::|:..|.
Mouse   939 AM-----DAIQGCDVNLKEQ---------GQLVRQDEFTVRA--GRHKACRRVFLFEELLLFSKP 987

  Fly   675 LHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDK 739
            .....|...:||:.|..:||..:.:...      :::.::::...|:..:..|.|.......:..
Mouse   988 RRGPAGVDIFTYKRSFKMADLGLTECCG------ESQLRFEIWFRRRKARDLFVLQASDVATKQA 1046

  Fly   740 W 740
            |
Mouse  1047 W 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 41/185 (22%)
PH_Vav 624..753 CDD:269930 20/117 (17%)
PH 641..749 CDD:278594 18/100 (18%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
Plekhg4XP_006530585.2 SEC14 230..351 CDD:417771
SPEC 475..>626 CDD:413338
RhoGEF 762..928 CDD:238091 41/178 (23%)
PH_puratrophin-1 928..1063 CDD:270062 26/147 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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