DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and plekhg1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021325545.1	Gene:	plekhg1 / 101886810	-ID:	-	Length:	1513	Species:	Danio rerio

Alignment Length:	724	Identity:	157/724 - (21%)
Similarity:	271/724 - (37%)	Gaps:	204/724 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 PSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAA----VYNYRSSMASTEHEYAYIYSE 357
            |.|||..|    :...||....||:|....|:.:.....:    .|...||.||:...:..:...
Zfish    17 PEVPVGGA----VLNQVSGPIRSSALRYCSSRSMDSTHCSDRPVSYGSTSSSASSRDSHCSLGGR 77

  Fly   358 DDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSF 422
            .             ...:.||...|:.|...........:|||   :.....|...:|.|...|.
Zfish    78 P-------------VLGSTPERDRDSGAIRLELVPARQLEEEE---ESGRKTRKLTNQDAEIQSP 126

  Fly   423 EQR-----DYVIRELIDTESNYLDVLTALKTKFMGPLERH----LNQDELRLIFPRIRELVDIHT 478
            |.|     |.|:.|:::||..|:..|.::...::..:...    |..:|...:|..||::...::
Zfish   127 EGRKVQYVDRVVEEILETEKTYVQDLRSIVQDYLDCISNQSLLLLGDEERNSLFGNIRDIYRFNS 191

  Fly   479 KFLDKLRESLTPNAK-VKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCE 542
            :.|..|.:.   ||. |.:|:.|:...|.|.||.::|:....::..|.: |.:|:::.:.::  |
Zfish   192 ELLRDLEKC---NANPVAIAKCFVAKSEDFHIYTQYCTNYPRSVAVLTE-CMRNKMVAKFLR--E 250

  Fly   543 RDYNV-GKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR 606
            |..:: ..|.|...|..|:||||||||||.::........:.|..::.|.:.|..|:.:||::||
Zfish   251 RQESLKHSLPLGSYLLKPVQRILKYHLLLHEIATHLEKDSEMYDVIQEAIDTMQRVAWHINDMKR 315

  Fly   607 DSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIM 671
            ..:|.|.:|:::.      ||.|..|.||:.||.|:|:|...|:..::::|    .|:|||:|::
Zfish   316 KHEHAVRLQEIQS------LLTNWKGPDLIGYGELVLEGTFRIQRAKNERT----LFLFDKLLLI 370

  Fly   672 VK-------------------------------ALHIKTGDMQYTYRD----------------- 688
            .|                               ..|.|...:|:|.:.
Zfish   371 TKKREETYSYKAHILCCNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKKMWVLHLKRLI 435

  Fly   689 ---------------------------SHNLADYRV--EQSHSRRTIGRDTRFKYQLLLARK--- 721
                                       :||..|.||  ::..|.|.:.|.|....:||...|
Zfish   436 LENHPAKIPAKAKQAILEMDTANHPSFNHNSDDKRVNTKEGPSPRRVRRKTEPLSKLLKNSKHII 500

  Fly   722 -----SGKTAFTLYLKSE----HERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTT---- 773
                 ..:::|.:.|.|.    ....:.|..::|:.|||:|......|        |.|.|
Zfish   501 SSPDIQKRSSFGVTLLSPVASLGSIGRSRSLVSESQESLDPGDHSDVD--------DEPNTQDAD 557

  Fly   774 ------------CRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLS 826
                        .|...|..:.|::|       |:||     .|..:.:.|.::
Zfish   558 DEDDTGLSSGGKLRVPGKGSRKRLNQ-------QVSV-----DSIEQWRNNDLT----------- 599

  Fly   827 EFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYAL----------SLKTDDNVIK 881
                   :.|.:||...|:|:.|...:|||.....|...|.:.|:          ::.||..|.:
Zfish   600 -------HADLQTAKQSLQNKVITPPILRVTAPPESDGDEHLRAMLGTGQAPAFCNIWTDHRVRR 657

  Fly   882 HMKINQENS 890
            .|...::.|
Zfish   658 AMFPTRQKS 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	47/180 (26%)
		PH_Vav	624..753	CDD:269930	43/217 (20%)
		PH	641..749	CDD:278594	32/196 (16%)
		C1_1	761..804	CDD:278556	10/58 (17%)
		SH2_Vav_family	824..934	CDD:198193	17/77 (22%)
		SH3	940..993	CDD:302595
plekhg1	XP_021325545.1	RhoGEF	137..312	CDD:214619	47/180 (26%)
plekhg1	XP_021325545.1	PH_PLEKHG1_G2_G3	293..438	CDD:270063	34/154 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910