DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Plekhg2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006539499.1	Gene:	Plekhg2 / 101497	MGIID:	2141874	Length:	1366	Species:	Mus musculus

Alignment Length:	328	Identity:	83/328 - (25%)
Similarity:	144/328 - (43%)	Gaps:	46/328 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 VIRELIDTESNYLDVLTALKTKFMGPL----ERHLNQDELRLIFPRIRELVDIHTKFLDKLRESL 488
            |.||:::||..|:..|.::...::|||    ...||.:::..:|..|.::.:..::.|:.|....
Mouse   103 VAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELLEDLEGCS 167

  Fly   489 TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNV-GKLQL 552
            :...   :|:.|:...|.|.||..:|.....::..|.::.........|.   ||...: ..|.|
Mouse   168 SAGG---IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQ---ERQAQLRHSLPL 226

  Fly   553 RDILSVPMQRILKYHLLLDKLVKE--TSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQ 615
            :..|..|:||||||||||.:|.|.  ..|.......:|.|..:|..|:.|||::||..:|...:|
Mouse   227 QSFLLKPVQRILKYHLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQ 291

  Fly   616 KVKDSICDIHLLQNGNGSDLLQYGRLLLDGEL--------HIKAHEDQKTKLRYAFVFDKILIMV 672
            :|:      ..|....|.:|..:|.|:|:|..        .::..|      |..|:|.::|::.
Mouse   292 EVQ------RRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGE------RLLFLFSRMLLVA 344

  Fly   673 KALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHER 737
            |    :.|. :|||:......:..|.:: .|..:|    ||...|...|.   ......|::.|:
Mouse   345 K----RRGP-EYTYKGHIFCCNLSVSET-PRDPLG----FKVSDLTIPKH---RHLFQAKNQEEK 396

  Fly   738 DKW 740
            ..|
Mouse   397 RLW 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	50/181 (28%)
		PH_Vav	624..753	CDD:269930	27/125 (22%)
		PH	641..749	CDD:278594	23/108 (21%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:366202	49/180 (27%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	39/165 (24%)
		PTZ00449	<351..742	CDD:185628	13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940