DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and RASGRP1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_005730.2	Gene:	RASGRP1 / 10125	HGNCID:	9878	Length:	797	Species:	Homo sapiens

Alignment Length:	803	Identity:	161/803 - (20%)
Similarity:	268/803 - (33%)	Gaps:	271/803 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 DLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVI 429
            |.|..:|.|        |...|          :..::.|.:..:||.    ..||....|:...:
Human    67 DSCIQSFDA--------DGNLC----------RSNQLLQVMLTMHRI----VISSAELLQKVITL 109

  Fly   430 RELIDTESNYLDVLT------ALK---------TKF--MGPLERHLNQDELRLIFPRIRELV--- 474
                     |.|.|.      .||         |:|  |..::..|..     .....:|||
Human   110 ---------YKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTD-----TMEEFQELVKAK 160

  Fly   475 --DIHTKFLD-----------KLRESLTPN-AKVKMAQVFLDFREP-----FLIYGEFCSLLLGA 520
              ::|.:.:|           ||.:.:..| :|.:...:..|..||     .|.|.||.|....:
Human   161 GEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRIS 225

  Fly   521 I----DYLADVC-KKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPL 580
            .    :||.:.| |:|..:::.:..|.   .:.:.....:||.|..: |:..:.: |.::....|
Human   226 FSDYQNYLVNSCVKENPTMERSIALCN---GISQWVQLMVLSRPTPQ-LRAEVFI-KFIQVAQKL 285

  Fly   581 HD--------------DYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDS----------- 620
            |.              .:.|:.|.||....|...||:|..:...|:...:..|:
Human   286 HQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDF 350

  Fly   621 ---ICDIHLLQNGNGSDLLQ-YGRL---LLDGELHIKAHEDQKTKLRYAFVFDKILIMVKA---- 674
               |..:||      .||:. |..:   |.||::::     .|....|..:.:.:.:...|
Human   351 KIPILGVHL------KDLISLYEAMPDYLEDGKVNV-----HKLLALYNHISELVQLQEVAPPLE 404

  Fly   675 -----LHIKT--GDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSG--------- 723
                 :|:.|  .|:.||..:.:.|:..|..::|....:   |..|..:::...||
Human   405 ANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPL---TPSKPPVVVDWASGVSPKPDPKT 466

  Fly   724 ------KTAFTLYLKSEHERDKWRKALTEAMESL-------------EPPGCQSTD--------- 760
                  :...:::...:|::|.:  ...|..|.:             :..|..|.|
Human   467 ISKHVQRMVDSVFKNYDHDQDGY--ISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRA 529

  Fly   761 ------------HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCIS-STGRCK-- 810
                        |..:..|:..||.|.:|:.||.|.|.||||||.|.::.||.|.. ....||
Human   530 SSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKR 594

  Fly   811 -QNPV-------SVPP--PVCDRQLSE---------FNWFAG--------NMDRETAAHRLENRR 848
             :|||       ||.|  .:|.....:         |.:..|        :.||......:.:::
Human   595 AKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQK 659

  Fly   849 IGTYLLR--------------VRPQGPS----------TAHETMYALSLKTDD-----NVIKHMK 884
            |...|.|              :..:|||          ||.:|:|.|...|..     .|.|...
Human   660 ISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAF 724

  Fly   885 INQENSGDSMLYCLSSRRHFK--TIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEP 947
            :..||. ||::......||.:  |..||..  |.|.|..:...|...|::..|::
Human   725 VKWENK-DSLIKSKEELRHLRLPTYQELEQ--EINTLKADNDALKIQLKYAQKKI---------- 776

  Fly   948 KAGSNQLQLRTDCQVLVIGKDGD 970
                ..|||.....||...:.||
Human   777 ----ESLQLEKSNHVLAQMEQGD 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	45/232 (19%)
		PH_Vav	624..753	CDD:269930	27/171 (16%)
		PH	641..749	CDD:278594	21/136 (15%)
		C1_1	761..804	CDD:278556	20/42 (48%)
		SH2_Vav_family	824..934	CDD:198193	32/157 (20%)
		SH3	940..993	CDD:302595	7/31 (23%)
RASGRP1	NP_005730.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		RasGEFN	54..175	CDD:214571	26/143 (18%)
		Ras exchanger motif region, required for transforming activity. /evidence=ECO:0000250	57..110		12/73 (16%)
		RasGEF	201..437	CDD:214539	50/251 (20%)
		EF-hand_7	478..527	CDD:372618	7/50 (14%)
		C1_1	542..591	CDD:365894	20/48 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694		3/20 (15%)
		Suppress the PT region-mediated translocation to plasma membrane. /evidence=ECO:0000250	686..694		2/7 (29%)
		PT region, mediates the BCR-dependent translocation to plasma membrane. /evidence=ECO:0000250	718..797		24/95 (25%)
		bZIP	<734..780	CDD:389750	11/61 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910