Protein Alignment Vav and vav1

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_002940062.1
• Gene: vav1 / 100497964
• XenbaseID: XB-GENE-6074281
• Length: 844
• Species: Xenopus tropicalis
• Alignment Length: 1078
• Identity: 284/1078 - (26%)
• Similarity: 439/1078 - (40%)
• Gaps: 344/1078 - (31%)

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||.|..||.:|:|:||:|:.....|::..||..||||||||.|:.:|.|::::..|.|.:|||
 Frog     2 ELWRHCARWLIQCRVLPPNHRVTLDTAQVCDLAQALRDGVLLCQLLNNLMPNAVNLSEINLRPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...|.:|.|||||...|:|:.:|.:|:.|||.||.....|..     |:
 Frog    67 SQFLCLKNIRTFLSTCSEKFKMRRADLFEAFDLFDVRDFGKVIDTLSILSWTSVAQNR-----GY 126

  Fly   149 NLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
              :..|||...:|:.||..|                                    ||...:.|.
 Frog   127 --EPFPTEELETDDDIYSGL------------------------------------SDQIDDTGE 153

  Fly   214 EDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVT 278
            ||.|.|                            ||             :|
 Frog   154 EDEDLY----------------------------DC-------------VD-------------- 163

  Fly   279 PTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSS 343
                                                                             
 Frog   164 ----------------------------------------------------------------- 163

  Fly   344 MASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
                      :..|:..::||||    .:.:.:|...||
 Frog   164 ----------MEEEEGNEIYEDL----MKLEEQPAAPTD-------------------------- 188

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIREL 473
                    ...||.:.|...::||..||..|.|.|.::...||.||:..|:|:|...||..|:||
 Frog   189 --------GKMTSDDMRRCCLQELYQTEEKYTDTLESITQYFMKPLQMFLSQNETNSIFINIKEL 245

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
            :.:|..||.:::......::..:.||||..:|.|||||.:||.:..|..:|.....:::.:...:
 Frog   246 LALHQVFLSEMKSCALYKSQQNLYQVFLRNKEKFLIYGTYCSQVESATKHLEKTSMEHEGVRMKL 310

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKET-SPLHDDYRSLERAKEAMIDVSQYIN 602
            ::|.:..|.|:..|||:|.|||||:|||||||.:|||.| .|...|  :|:.:.:||.|::|.:|
 Frog   311 EECSQRANNGRFSLRDLLMVPMQRVLKYHLLLQELVKHTVDPTEKD--NLKLSLDAMRDLAQCVN 373

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKL-RYAFVFD 666
            |||||::.|..|...:.||      :|...| |.||||...||||.:...| :|:|| ||||:.|
 Frog   374 EVKRDNETLKQITNFQLSI------ENLTDS-LAQYGRPKTDGELKVTTME-RKSKLDRYAFLLD 430

  Fly   667 KILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFTLY 730
            :.|::.|    :.|| .:..::...|.::::....|.   .:|. ::.:..||....|...:.||
 Frog   431 RALLICK----RKGD-TFDLKEFIKLQNFQIRDDSSG---DKDNKKWSHMFLLIDARGTLGYELY 487

  Fly   731 LKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQ 795
            .|:...:.||.:....|:.::.|....:..|..::::|:...||:.|...|:|...|||||..|:
 Frog   488 FKTRELKKKWMEQFEMALSNIYPDNALANGHDFQMFSFEDTATCKACQMLLRGLFFQGYRCCRCK 552

  Fly   796 ISVHKGCISSTGRC-----------KQNP----------------------VSVPPP-------- 819
            ...||.|:.....|           ||.|                      |.:|||
 Frog   553 APAHKECLGRVPCCGKQDSGSSTIKKQKPGRGNNNKRNETGLTKMEACQEYVGIPPPPIAFGPPL 617

  Fly   820 -----------------------------------------VCD--RQLSEFNWFAGNMDRETAA 841
                                                     ||:  ..||.:.|:||.|:|..|.
 Frog   618 RMEKGVIVELTKAEADQHWWEGRNTSSNEIGFFPCSHVKPYVCNPVPDLSVYTWYAGPMERRDAE 682

  Fly   842 HRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKT 906
            ..|.||..||||:|.|.:....     :|:|:|.:..| ||||:..:..    |:.|:.::.||.
 Frog   683 VLLANRSDGTYLVRQRVKDAGE-----FAISIKFNQEV-KHMKVTSQGG----LWRLTEKKGFKG 737

  Fly   907 IVELVSYYERNDLGENFAGLNQSLQWPYKEV----------------IATALYDYEPKAGSNQLQ 955
            :.:|:.||::|.|.:.|..|:..||.|:||.                .|.|.||:..: ...:|.
 Frog   738 LTDLIVYYQQNSLKDCFKLLDTMLQNPFKEPEKKDNPKTEKRMKYFGSARARYDFCAR-DRTELS 801

  Fly   956 LRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
            |:....:.::.|.|.: |||:|::...||:||..||::
 Frog   802 LKEGDVIRILSKKGQN-GWWKGEVYGKVGWFPANYVED 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	54/111 (49%)
		RhoGEF	428..603	CDD:279015	66/175 (38%)
		PH_Vav	624..753	CDD:269930	36/130 (28%)
		PH	641..749	CDD:278594	29/109 (27%)
		C1_1	761..804	CDD:278556	16/42 (38%)
		SH2_Vav_family	824..934	CDD:198193	38/109 (35%)
		SH3	940..993	CDD:302595	17/52 (33%)
vav1	XP_002940062.1	CH	18..103	CDD:381763	41/84 (49%)
		RhoGEF	197..373	CDD:238091	67/177 (38%)
		PH_Vav	387..510	CDD:269930	38/138 (28%)
		C1_1	518..567	CDD:365894	16/48 (33%)
		SH3_VAV1_1	596..658	CDD:212912	4/61 (7%)
		SH2	665..767	CDD:387587	39/111 (35%)
		SH3_VAV1_2	785..838	CDD:212909	18/54 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3961
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1566
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm48207
Panther	1	1.100	-	-	LDO	PTHR45818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190