Protein Alignment Vav and mcf2l

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_012813354.1
• Gene: mcf2l / 100497730
• XenbaseID: XB-GENE-6042031
• Length: 1216
• Species: Xenopus tropicalis
• Alignment Length: 1077
• Identity: 205/1077 - (19%)
• Similarity: 365/1077 - (33%)
• Gaps: 362/1077 - (33%)

  Fly    50 LAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPT 114
            |.:.|..|..:.|.:       ::||:.|.:.:|.|                            .
 Frog   286 LKIALTQGCDILNKI-------MEPRKENPEYRMNQ----------------------------D 315

  Fly   115 MLYDLTNFHRVLITLS---------------KLSQCRKV-------QQLHPDLIGFNLQLSP--- 154
            .|.:.|...|:|:.|:               ||.||.::       :::...|.|.:.:|..
 Frog   316 QLDNQTTVERLLLQLNETEAAFDEFWSKHEQKLEQCLQLRHFELNFREISTSLDGISERLEAFTD 380

  Fly   155 --TERSHSDEAIYKDLHSTDLNMRKTSSI------DASASSSAEYY------DRTSQSGSLDENS 205
              ...||: |.|.||..:.::..|:....      :......:.:|      .:..:.|.|.::.
 Frog   381 VGNSCSHA-EHILKDFCNFEVKSREVLQTAQNLVREGDQLIKSNHYAVDSILPKCDEIGHLCDSI 444

  Fly   206 DITIENGTEDIDDYIE-----DSLSNMCDSTI------------DNDAEDAGVE--TPLLSDCQG 251
            ..||:...:::...:|     :.....||..|            ..|..:|.::  |..|.....
 Frog   445 SNTIQQRRQNLHKSLELHRHLEKTMKWCDEGIFLLASQPVDKFQSQDGAEAALQEITRFLETGTD 509

  Fly   252 SHVRELSFDLAL--DVVSSTTDGASNAVTPTPESY-----ARQSQSPLAAAAPSVPVSAAPGPPM 309
            ..:::|:|.|.:  .:::.......|.|....||.     .|:......||..:.||.  |..|.
 Frog   510 ITMKDLAFILKMYNSILTPELQEHVNKVYQKQESMQEMFEKRKGSLRKLAAKQTRPVQ--PVAPR 572

  Fly   310 GRLVSTSSSSSSLL--VSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQ 372
            ...:|.|.:||..|  .|||:....:.....|||
 Frog   573 PEAISKSPTSSPGLHRSSESRYSSGSIQRRINYR------------------------------- 606

  Fly   373 AKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTES 437
             :||.||       :|:....|:..|:|  ::|..|.|                :|:.|||:||.
 Frog   607 -RAKSEV-------DGSQMRSTSVMEDE--ENLAVLRR----------------HVMNELIETER 645

  Fly   438 NY----LDVLTALKTKFMGPLERHL----NQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKV 494
            .|    |.|:.....:...||...|    .|::..::|..:.|:...|.:...:..|......::
 Frog   646 AYVEELLSVIEGYAAEMNNPLVMDLIPSVLQNKKDVLFGNMEEIYQFHNRIFLRELEHYRDYPEL 710

  Fly   495 KMAQVFLDFREPFLIYGEFC-------SLLLGAID--YLADVCKKNQIIDQLVQKCERDYNVGKL 550
             :.:.||:..|.|.||.::|       ||.....|  :..|..||   :|.            ||
 Frog   711 -VGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDAAFFQDCQKK---LDH------------KL 759

  Fly   551 QLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQ 615
            .|...|..|:|||.||.|||.:::|.:.    :....|..:||:..:             |.|::
 Frog   760 SLDSYLLKPVQRITKYQLLLKEMLKYSK----NCEGAEDLQEALASI-------------LGILK 807

  Fly   616 KVKDSICDIHLLQNGNGSDLLQYGRLLLDGEL-----HIKAHEDQKTKLRY------AFVFDKIL 669
            .|.||:..|.:  .|...:|.:.|:||:.|..     |.|.|...|...|:      .|:.:|.:
 Frog   808 AVNDSMHQIAI--TGYEGNLHELGKLLMQGSFNVWTEHKKGHSKVKDLARFKPMQRHLFLHEKAV 870

  Fly   670 IMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSE 734
            :..|.            || .|...|....|:|         :|:.|.:.    ....|.|:|.:
 Frog   871 LFCKK------------RD-ENGEGYEKAPSYS---------YKHSLNMM----FVGITEYVKGD 909

  Fly   735 HER-DKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISV 798
            :.: :.|..|                  :.|:|...||||     :.....:::..:....|:..
 Frog   910 NRKFEIWYNA------------------REEVYIVQAPTT-----EVKATWVNEIRKVLTSQLKA 951

  Fly   799 HKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNM----DRET------------AAHRLENR 847
            |:.  :|..:..::..|:|.|: ....|.....:|.:    :|:|            ....||..
 Frog   952 HRD--ASHHKSAEHANSLPTPL-PSSTSPLRNKSGKIKKLEERKTEPLLNPDVSLTSVPKYLEKG 1013

  Fly   848 RIGTYL---------------------LRVRPQGPSTAHETMYALSLKTDD--------NVIKH- 882
            :.||..                     |:.:...|::..:......:|:|.        |...|
 Frog  1014 KDGTVTSPTSDSSALSKKRFTLQGFSNLKSQKASPTSPDKKAKRHEVKSDPTPFGLRGWNRASHS 1078

  Fly   883 MKINQEN-----SGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIA--- 939
            :.:::||     ||:..:                   ..:|..|:..|     ..|.|::..
 Frog  1079 LDVSEENNEDWSSGEDPI-------------------NSSDAEEDGGG-----DAPEKKLTPGKY 1119

  Fly   940 TALYDYEPKAGSNQLQLRT-DCQVLVIGKDGDSKGWW 975
            |.:.|||  .||::|.::: |...::..:||   |.|
 Frog  1120 TVVADYE--RGSDELLVKSGDLVHIIHEEDG---GMW 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	14/96 (15%)
		RhoGEF	428..603	CDD:279015	48/191 (25%)
		PH_Vav	624..753	CDD:269930	28/140 (20%)
		PH	641..749	CDD:278594	24/119 (20%)
		C1_1	761..804	CDD:278556	8/42 (19%)
		SH2_Vav_family	824..934	CDD:198193	21/160 (13%)
		SH3	940..993	CDD:302595	12/37 (32%)
mcf2l	XP_012813354.1	SEC14	77..222	CDD:214706
		SPEC	353..561	CDD:238103	32/208 (15%)
		RhoGEF	633..810	CDD:238091	51/225 (23%)
		PH_Dbs	817..948	CDD:269934	33/181 (18%)
		PTZ00108	<958..1104	CDD:240271	22/165 (13%)
		SH3_DBS	1118..1171	CDD:212791	12/39 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910