DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and plekhg5

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_031761469.1	Gene:	plekhg5 / 100496612	XenbaseID:	XB-GENE-6039487	Length:	1129	Species:	Xenopus tropicalis

Alignment Length:	864	Identity:	166/864 - (19%)
Similarity:	300/864 - (34%)	Gaps:	274/864 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQ 197
            :.|:::.|.:|    .||..|...:.||  .::.|.| ...::....||.|...|:.....|||.
Frog    32 ADCQQMNQKNP----LNLCESCDIKFHS--TMHFDKH-IRFDLPPQGSILARNVSTRSCPPRTSP 89

  Fly   198 SGSLDENSDITIENGTED-----------------IDDYIEDSLSNMCDSTIDNDA--------- 236
            :..::|: |..:.:|..|                 .||..::..:...|..:|.:.
Frog    90 ASDVEED-DEELMDGKGDKKAAGLKLSKKKTRRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKK 153

  Fly   237 ----------EDAGVE------------TPLLSDCQ----GSHVRELSF---------------- 259
                      |..|::            |||..:.:    |.|..::..
Frog   154 SLGEVLIPAFERKGIDLNKVDIFLDQSNTPLSLNFEAYRFGGHYLKVKAKPGDEVKVEQAVKDFR 218

  Fly   260 DLALDVVSSTTDGASNA--VTPT-----PESYARQS------------------------QSPLA 293
            .|:|.::.:|  ||::|  ..|.     |..:.|::                        |.||.
Frog   219 SLSLPIMRNT--GATSAFIFNPAAERSDPPPFRRENTDILAPGRRRKNMNEFLGDASIPVQDPLQ 281

  Fly   294 AAAPSVP-------------------VSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYN 339
            :.:.|:|                   .|||.| |.||              |..::::..:.:::
Frog   282 SFSCSLPNNGTDTWKNRAASRFSGFFGSAATG-PFGR--------------EIDKMEQLESKLHS 331

  Fly   340 YRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQD 404
            |  ||....   .:.:.:|..:..||..|:|.                           |:.:|:
Frog   332 Y--SMFGLP---KFGFDQDSWEEEEDDTYLTL---------------------------EDSWQE 364

  Fly   405 LCALHRT-SRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRL--- 465
            :..:..| :|.|.       .:...|.||:.||:.|:..|..:...|:..|   ||..|..:
Frog   365 IIEVPETLTRRQC-------HQQEAIWELLHTEATYIKKLKVITDLFLCCL---LNLQESGILCE 419

  Fly   466 -----IFPRIRELVDIH--------TKFLDKLRES---LTPNAKVKMAQVFLDFREPFLIYGEFC 514
                 :|..|:|::.:|        ...|:|.|::   |.|....|..::|....:|::.|   |
Frog   420 VEPDKLFSNIQEIIQLHRTLWSTVMVPILEKARKTKSLLNPMDFQKGFKMFESLFKPYIRY---C 481

  Fly   515 SLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSP 579
            ....|.::|:.::.:.|::....|...|:.....:|:|.|:|..|.||:.||.|||..::|:|..
Frog   482 MEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKLSDMLVKPHQRLTKYPLLLKSILKKTDD 546

  Fly   580 LHDDYRSLERAKEAMI----DVSQYINEV------KRDSDHLVII-----------------QKV 617
            |        :.:|::|    .|.::||.|      :::...|..|                 .|:
Frog   547 L--------QVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVDKI 603

  Fly   618 KDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDM 682
            ....|.:.|.....|:......:|||:|.|.:|..:|.|..: |.|:|..:.::.|.  :|..:.
Frog   604 LKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDV-YCFLFTDLFLITKP--VKKAER 665

  Fly   683 QYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR----KSGKTAFTLYLKSEHERDKWRKA 743
            ....|.. .|.|         :.:.|:.:.....||..    :|...|:|.....:.....|.:|
Frog   666 TKVIRQP-LLVD---------KIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEA 720

  Fly   744 LTEAMESL------------EPPGCQSTDHKMEIYTFDA--PTTCRHCSKFLKGRIHQGYRCKVC 794
            ...|...|            :.|..|..:..||..|..|  ||..|..|..:......|....:.
Frog   721 FFNAQNLLQRMRQECLRNQQQVPHLQEEEEDMESGTSAASSPTILRRSSADMLNSQSDGSTETIS 785

  Fly   795 QISVHKGCISSTGRCKQNP 813
            .:.:..|...|:...:|.|
Frog   786 VVVIDAGDELSSPETEQGP 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	50/197 (25%)
		PH_Vav	624..753	CDD:269930	28/144 (19%)
		PH	641..749	CDD:278594	25/111 (23%)
		C1_1	761..804	CDD:278556	10/44 (23%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
plekhg5	XP_031761469.1	RBD_PLEKHG5	129..203	CDD:340588	9/73 (12%)
		RhoGEF	379..568	CDD:238091	51/202 (25%)
		PH_PLEKHG5_G6	625..721	CDD:270064	23/108 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910