DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and kiaa1755

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_002932909.3	Gene:	kiaa1755 / 100495112	-ID:	-	Length:	1536	Species:	Xenopus tropicalis

Alignment Length:	897	Identity:	174/897 - (19%)
Similarity:	297/897 - (33%)	Gaps:	278/897 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DPREFNRK--PQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFH----RVLITLSK 131
            |..:|||.  |:|..|..::          ::|..|            ||:|:    |....|.|
Frog   682 DANKFNRSHFPEMESFKTAR----------SSFQTR------------LTSFYMCVERQKEELEK 724

  Fly   132 L----SQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYY 192
            |    |.|.|:.||......:..||..:|:........:.|.|  ...|.|..:.|.     ::.
Frog   725 LLNLYSFCDKISQLTVSCSRYLGQLKKSEQKLCLPETRQCLES--YLQRLTDELSAD-----KFQ 782

  Fly   193 DRTSQSGSLDENSDITIENGT----EDIDDYIEDSL---------------------SNMCDSTI 232
            :...:|.||..:..:|:.|.|    ::....:|::|                     ||....:.
Frog   783 EMKEESYSLSSSRGLTVWNETWLRCQESRQLLEETLEKCKEEQRTDVAGRHKDTSGSSNSKKQSA 847

  Fly   233 DNDAEDAG---------------------VETPLLSDCQ-GSHVRELSFDLALD----------- 264
            |..|..:.                     .||.:::.|. |.|...:...|...
Frog   848 DTPAGFSNEVSPRNQRGEEEFRPRGSMRTAETTVINCCSFGLHTGSVGLFLKASRNNRNRRPARE 912

  Fly   265 -VVS---STTDGASNAVTPTPE--------------SYARQSQSPLAAAAPSVPVSAAPGPPMGR 311
             |:|   ||::.:.::....||              ...|.....|:...|..|..|:....:|.
Frog   913 PVISKGCSTSEESRSSSDADPEHTELMVQNSNNEALEILRSPSPTLSRTTPVPPPCASKSDHLGW 977

  Fly   312 LVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEH----EYAYIYSEDDEKVYEDLCYVTFQ 372
            |....|     |..:|..:.|..|.    ||.|....|    .:|...:.|....|..    ...
Frog   978 LALGRS-----LSDDSSTISRGDAG----RSVMQPGRHCPLSRHASFSTGDSGSQYSS----ESS 1029

  Fly   373 AKAKPEVTTDNIA-----CNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIREL 432
            :...|.:..:.:.     ..||..|.:...:..:..:...:|:                 ::.||
Frog  1030 SLISPLLAMEPLIPRMPWTRGTMSDSSRESDWSMKANFAKMHK-----------------IMEEL 1077

  Fly   433 IDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIRELVDIHTK-FLDKL----RESL 488
            :.||.:|:..|..:.:.::..::|......||    .||..:.:|.:.|:. ||.:|    ||
Frog  1078 LATERDYVCSLGYVLSHYLSEMDRSDVPSTLRGQHAAIFGNLEKLYEFHSHVFLQELTSCRRE-- 1140

  Fly   489 TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ-------KCERDYN 546
             |:.   :...||..::.|.:|              |...|.....|:|:|       |.::...
Frog  1141 -PSL---VGGCFLKHKDQFGLY--------------AFYSKNKPQSDRLLQEHGAAFFKRKQQEL 1187

  Fly   547 VGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHL 611
            ..|:.|...|..|:|||.||.|||..|..|..........|:.|:|.       :....|..:.|
Frog  1188 KDKMDLSSYLLKPIQRISKYSLLLQDLEWELKGQSTRQAELQAAREV-------VRFQLRHGNDL 1245

  Fly   612 VIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALH 676
            :.:..::|  ||::|.:.         ||||..||..|.  ..:|...|..|:|:.:::..||..
Frog  1246 LAMDAIQD--CDVNLKEQ---------GRLLRQGEFMIS--YKKKKCWRRVFLFEDLILFSKAKK 1297

  Fly   677 IKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW- 740
            ..:|...|.|:.|     ::..:.....|:| .:...:::...|:..:..:||...|...::.|
Frog  1298 TSSGSEVYVYKQS-----FKTSEIGLTHTLG-GSGLCFEIWFRRRKLEDTYTLQAPSAEVKEAWT 1356

  Fly   741 ---RKAL-TEAMESLEPP---------GC------QSTDHKMEIYTF----------------DA 770
               :|.| .:|:::.|..         ||      |.:|..:...|.                .:
Frog  1357 GDLQKILWDQAIKNREMRRQERVFSGIGCKPFTDIQPSDSAISSRTVPDDNLRSSPAVTLPFPTS 1421

  Fly   771 PTTCRH-----------------CSKFLKGRIHQGYRCKVCQISVHKGCISS 805
            |...|.                 ||....||         ..:|.|.||.||
Frog  1422 PVPLRSMSVGSRSSASSAVSLGGCSSTSSGR---------GSLSPHHGCPSS 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	14/64 (22%)
		RhoGEF	428..603	CDD:279015	46/190 (24%)
		PH_Vav	624..753	CDD:269930	28/133 (21%)
		PH	641..749	CDD:278594	25/112 (22%)
		C1_1	761..804	CDD:278556	11/75 (15%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
kiaa1755	XP_002932909.3	SEC14	388..492	CDD:417771
		SPEC	494..726	CDD:413338	15/65 (23%)
		RhoGEF	1070..1236	CDD:238091	47/209 (22%)
		PH_puratrophin-1	1236..1371	CDD:270062	33/153 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910