Protein Alignment Vav and KIAA1755

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_002932909.3
• Gene: KIAA1755 / 100495112
• XenbaseID: XB-GENE-29077363
• Length: 1536
• Species: Xenopus tropicalis
• Alignment Length: 897
• Identity: 174/897 - (19%)
• Similarity: 297/897 - (33%)
• Gaps: 278/897 - (30%)

  Fly    73 DPREFNRK--PQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFH----RVLITLSK 131
            |..:|||.  |:|..|..::          ::|..|            ||:|:    |....|.|
 Frog   682 DANKFNRSHFPEMESFKTAR----------SSFQTR------------LTSFYMCVERQKEELEK 724

  Fly   132 L----SQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYY 192
            |    |.|.|:.||......:..||..:|:........:.|.|  ...|.|..:.|.     ::.
 Frog   725 LLNLYSFCDKISQLTVSCSRYLGQLKKSEQKLCLPETRQCLES--YLQRLTDELSAD-----KFQ 782

  Fly   193 DRTSQSGSLDENSDITIENGT----EDIDDYIEDSL---------------------SNMCDSTI 232
            :...:|.||..:..:|:.|.|    ::....:|::|                     ||....:.
 Frog   783 EMKEESYSLSSSRGLTVWNETWLRCQESRQLLEETLEKCKEEQRTDVAGRHKDTSGSSNSKKQSA 847

  Fly   233 DNDAEDAG---------------------VETPLLSDCQ-GSHVRELSFDLALD----------- 264
            |..|..:.                     .||.:::.|. |.|...:...|...
 Frog   848 DTPAGFSNEVSPRNQRGEEEFRPRGSMRTAETTVINCCSFGLHTGSVGLFLKASRNNRNRRPARE 912

  Fly   265 -VVS---STTDGASNAVTPTPE--------------SYARQSQSPLAAAAPSVPVSAAPGPPMGR 311
             |:|   ||::.:.::....||              ...|.....|:...|..|..|:....:|.
 Frog   913 PVISKGCSTSEESRSSSDADPEHTELMVQNSNNEALEILRSPSPTLSRTTPVPPPCASKSDHLGW 977

  Fly   312 LVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEH----EYAYIYSEDDEKVYEDLCYVTFQ 372
            |....|     |..:|..:.|..|.    ||.|....|    .:|...:.|....|..    ...
 Frog   978 LALGRS-----LSDDSSTISRGDAG----RSVMQPGRHCPLSRHASFSTGDSGSQYSS----ESS 1029

  Fly   373 AKAKPEVTTDNIA-----CNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIREL 432
            :...|.:..:.:.     ..||..|.:...:..:..:...:|:                 ::.||
 Frog  1030 SLISPLLAMEPLIPRMPWTRGTMSDSSRESDWSMKANFAKMHK-----------------IMEEL 1077

  Fly   433 IDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIRELVDIHTK-FLDKL----RESL 488
            :.||.:|:..|..:.:.::..::|......||    .||..:.:|.:.|:. ||.:|    ||
 Frog  1078 LATERDYVCSLGYVLSHYLSEMDRSDVPSTLRGQHAAIFGNLEKLYEFHSHVFLQELTSCRRE-- 1140

  Fly   489 TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ-------KCERDYN 546
             |:.   :...||..::.|.:|              |...|.....|:|:|       |.::...
 Frog  1141 -PSL---VGGCFLKHKDQFGLY--------------AFYSKNKPQSDRLLQEHGAAFFKRKQQEL 1187

  Fly   547 VGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHL 611
            ..|:.|...|..|:|||.||.|||..|..|..........|:.|:|.       :....|..:.|
 Frog  1188 KDKMDLSSYLLKPIQRISKYSLLLQDLEWELKGQSTRQAELQAAREV-------VRFQLRHGNDL 1245

  Fly   612 VIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALH 676
            :.:..::|  ||::|.:.         ||||..||..|.  ..:|...|..|:|:.:::..||..
 Frog  1246 LAMDAIQD--CDVNLKEQ---------GRLLRQGEFMIS--YKKKKCWRRVFLFEDLILFSKAKK 1297

  Fly   677 IKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW- 740
            ..:|...|.|:.|     ::..:.....|:| .:...:::...|:..:..:||...|...::.|
 Frog  1298 TSSGSEVYVYKQS-----FKTSEIGLTHTLG-GSGLCFEIWFRRRKLEDTYTLQAPSAEVKEAWT 1356

  Fly   741 ---RKAL-TEAMESLEPP---------GC------QSTDHKMEIYTF----------------DA 770
               :|.| .:|:::.|..         ||      |.:|..:...|.                .:
 Frog  1357 GDLQKILWDQAIKNREMRRQERVFSGIGCKPFTDIQPSDSAISSRTVPDDNLRSSPAVTLPFPTS 1421

  Fly   771 PTTCRH-----------------CSKFLKGRIHQGYRCKVCQISVHKGCISS 805
            |...|.                 ||....||         ..:|.|.||.||
 Frog  1422 PVPLRSMSVGSRSSASSAVSLGGCSSTSSGR---------GSLSPHHGCPSS 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	17/71 (24%)
		RhoGEF	428..602	CDD:459876	46/189 (24%)
		PH_Vav	624..753	CDD:269930	28/133 (21%)
		C1_VAV	759..810	CDD:410360	14/80 (18%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
KIAA1755	XP_002932909.3	CRAL_TRIO_2	388..492	CDD:463965
		SPEC	494..726	CDD:413338	15/65 (23%)
		RhoGEF	1070..1236	CDD:238091	47/209 (22%)
		PH_puratrophin-1	1236..1371	CDD:270062	33/153 (22%)