DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and vav3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_012817964.1	Gene:	vav3 / 100493918	XenbaseID:	XB-GENE-6075609	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	283/1104 - (25%)
Similarity:	446/1104 - (40%)	Gaps:	372/1104 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            ||:|..||.||||:||:|:.....|::..||.|||||||||.|:.:|..:|::.:|.|.:|||:|
Frog     4 WRQCAQWLIRCKVLPPNHRVTLDTAQVFDLAQTLRDGVLLCQLLKNLQGNSINLKEINLRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDL-IGFN 149
            |||.|||:.||.||.:.||::.:||||...|:|:.:|.:|:.||||||        |..: :...
Frog    69 FLCLKNIRTFLSVCCDAFGMKKSDLFEAFDLFDVRDFAKVIETLSKLS--------HTTIALSAG 125

  Fly   150 LQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTE 214
            ::..|||.|..||.|||.|                                    .|:..|:|.:
Frog   126 IRPFPTEESVQDEDIYKAL------------------------------------PDLIDESGAD 154

  Fly   215 DIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTP 279
            :.|:                          |..||
Frog   155 EDDE--------------------------LYYDC------------------------------ 163

  Fly   280 TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSM 344

Frog   164 ----------------------------------------------------------------- 163

  Fly   345 ASTEHEYAYIYSEDD-EKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
                     :|.||: .:|||||        .|.|....|           .:.|.:| :..|.|
Frog   164 ---------VYQEDEGGEVYEDL--------MKAEAALPN-----------RSAESDV-RSCCLL 199

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIREL 473
                                  |:..||..|.:.|.:::..||.||:..|...:::.:|..|.|:
Frog   200 ----------------------EIKQTEEKYSETLDSIEKFFMEPLKNFLAPTDMQKVFINIPEM 242

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
            |::|...::::::|:.......:..:||.::|..|||||:||.:..||..|.::.|..:.:...:
Frog   243 VEVHRNLVNQIKDSVNHRNSQNLYMIFLTYKERLLIYGEYCSQVELAISVLDNISKTREDVRLKL 307

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE 603
            ::|.:..|.||..|||:|.|||||:|||||||.:|||.|:. ..:..:|..|.:||.|::||:||
Frog   308 EECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTD-PTEKNNLRVALDAMKDLAQYVNE 371

  Fly   604 VKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKI 668
            ||||::.|..|::.:      |.::|.| ..:.||||..:|||:.|...:.:..:.||.|:||:.
Frog   372 VKRDTETLREIEQYQ------HSIENLN-QPMSQYGRPKIDGEIRISTLDKRARQDRYIFLFDQA 429

  Fly   669 LIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKS 733
            :|:.|    :.|| .|..::..:|..|::..:.|  |...:.::.|...|....|:..|..:.|:
Frog   430 VIVCK----RRGD-NYDMKEIIDLQKYKITNNPS--TDKENKKWSYGFYLTHIQGQNGFEFFCKT 487

  Fly   734 EHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISV 798
            :..:.|..:....|:.::.|....:..|:.::::|.:.|:||.|...|:|...|||.|:.|....
Frog   488 KDLKKKLLEQFEMALSNIRPDNATANYHEFQMHSFKSVTSCRVCQMLLRGTFFQGYLCQKCGTGA 552

  Fly   799 HKGCISSTGRC-----------KQN----PVSVP------------------------------- 817
            ||.|:.....|           |||    ||..|
Frog   553 HKECLGRVDTCRRADSGTLKHEKQNGPRRPVKNPDPDVFSISLHLPMPAVEIPVTHEGLPKMKVI 617

  Fly   818 --------PPV------------------------------------------------CDRQLS 826
                    |||                                                |..:..
Frog   618 RNYSGFPSPPVHSGPSLSMQIGDTIEVLRADPHILFWQGRNLATGELGFFPSDTVKPSPCVPKPV 682

  Fly   827 EFN---WFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQE 888
            :::   |:||.|:|..|...|.:|...|||:|.|     |.....||:|:|. :|.:||:||...
Frog   683 DYSGQPWYAGAMERVQAESELISRENSTYLIRHR-----TKESGEYAISIKY-NNEVKHIKILTR 741

  Fly   889 NSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYK------------------ 935
            :.    .:.::..|.||:::|||.||:...|.|.|..|:..|..|||
Frog   742 DG----FFHIAENRKFKSLMELVEYYKHQSLREGFRSLDTKLLLPYKFPENHTGHACNRTSGSLF 802

  Fly   936 --EV--IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQK 995
              :|  ||.|.||:..: ...:|.|..:..|.:..|.| :.|||||:....||:||..||:|.:
Frog   803 SPKVLGIAIARYDFCAR-DMRELSLFKEDVVKIYTKSG-TNGWWRGESNGKVGWFPSTYVEEDE 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	56/110 (51%)
		RhoGEF	428..603	CDD:279015	61/174 (35%)
		PH_Vav	624..753	CDD:269930	32/128 (25%)
		PH	641..749	CDD:278594	25/107 (23%)
		C1_1	761..804	CDD:278556	16/42 (38%)
		SH2_Vav_family	824..934	CDD:198193	36/112 (32%)
		SH3	940..993	CDD:302595	19/52 (37%)
vav3	XP_012817964.1	CAMSAP_CH	18..103	CDD:314792	42/84 (50%)
		RhoGEF	194..370	CDD:238091	63/198 (32%)
		PH_Vav	384..507	CDD:269930	32/136 (24%)
		C1	515..563	CDD:237996	16/47 (34%)
		SH3_VAV3_1	613..674	CDD:212914	3/60 (5%)
		SH2_Vav3	683..785	CDD:198270	38/111 (34%)
		SH3_VAV3_2	808..863	CDD:212911	21/56 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1566
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm48207
Panther	1	1.100	-	-	O	PTHR45818
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160