DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and plekhg2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_002938639.3	Gene:	plekhg2 / 100492670	XenbaseID:	XB-GENE-6468886	Length:	1982	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	117/501 - (23%)
Similarity:	205/501 - (40%)	Gaps:	113/501 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PESYAR-QSQSPLAAAAP-SVPVSAAPGPPMGRLVSTSSSSSSLLVSESQR-----LQRAAAAVY 338
            ||..:| .|:.....||| ...||:..|...|  :|.|.:|.:.:.|:|.|     ...::|::.
Frog    39 PEGVSRGSSKRACKQAAPRPTSVSSLSGIVDG--MSGSCTSVNTVCSDSDRPVSLSSSTSSASLQ 101

  Fly   339 NYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQ 403
            :..||..|:.   |.:.|::                              ||..:|.....::..
Frog   102 DSHSSFGSSG---ALVSSQN------------------------------TGSCYTQQNGSDISL 133

  Fly   404 DL--CALHRTSRSQTASSTSF-------------------EQRDYVIRELIDTESNYLDVLTALK 447
            ||  .||......:.|....|                   ...|.|:.|:::||..|:..|.::.
Frog   134 DLTPVALLEGESERRAMDRPFLGYACSPILRKARDPKIKLSHVDRVVLEILETEQAYVRDLKSIV 198

  Fly   448 TKFMGPL----ERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFL 508
            ..::|.:    ...|..:::..:|..|.::.:.:::.|:.|...   |:...:|:.|:...|.|.
Frog   199 EDYLGCIIDCGHLPLKPEQVSTLFCNIEDIYEFNSELLEDLENC---NSAHGIAECFVMRSEDFD 260

  Fly   509 IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVG-KLQLRDILSVPMQRILKYHLLLDK 572
            ||..:|.....::..|.: |.|::.:.|..:  ||...:. .|.|...|..|:|||:||||||.:
Frog   261 IYTLYCMNYPNSVSVLRE-CMKSEELVQFFR--ERQAILSHSLPLETYLLKPVQRIMKYHLLLQE 322

  Fly   573 LVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQ 637
            |.|........|..:|.|...|..|:.|||::||..:|.|.:|:::..      |.|..|.||..
Frog   323 LAKHFDKNAPGYEVVEEAIITMTAVAWYINDMKRKQEHAVRLQEIQSQ------LVNWQGPDLSA 381

  Fly   638 YGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK--------ALHIKTGDMQYTYRDSHNLAD 694
            :|.|:|:|...::    :..|.|..|:|.|:|::.|        .:||...::..|......|:
Frog   382 FGELVLEGTFRVQ----RMKKERAFFLFSKMLLIAKKRMDLFIYKMHIFCCNLSLTEHLKDGLS- 441

  Fly   695 YRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW 740
            :||    |..||.:    ..|::.||            ::.|:..|
Frog   442 FRV----SDLTISK----HQQVIQAR------------NQEEKRHW 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/179 (27%)
		PH_Vav	624..753	CDD:269930	30/125 (24%)
		PH	641..749	CDD:278594	24/108 (22%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
plekhg2	XP_002938639.3	RhoGEF	179..352	CDD:395496	47/178 (26%)
plekhg2	XP_002938639.3	PH_PLEKHG1_G2_G3	334..478	CDD:270063	43/165 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910