DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and she

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_004920075.1	Gene:	she / 100490744	XenbaseID:	XB-GENE-6072915	Length:	437	Species:	Xenopus tropicalis

Alignment Length:	349	Identity:	81/349 - (23%)
Similarity:	125/349 - (35%)	Gaps:	103/349 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 DYRSLERAKE-----AMIDVSQYINEVKRDSDHLVIIQKVKDS-ICDIHLLQNGNGSDLLQYGRL 641
            |.|..||..|     ...|..|.|.|::|...        ||: |.::.||:.|....|
Frog   161 DPRDAERLGENDGYMEPYDAQQMITEIRRRGS--------KDNLITELLLLELGPPCGL------ 211

  Fly   642 LLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTI 706
                          ||.:|.. ...::|.....|:    |..|...|    |....|...::.:.
Frog   212 --------------KTVVRRP-GSQELLDRAPQLY----DTPYEPPD----AGGEAEPQENKGSA 253

  Fly   707 GRDTRFKYQLLLARKSGKTAFTLYLKSEHERD-KWRK-----ALTEAMESLEPPGCQSTDHKMEI 765
            |..||.:..   .|.:|          |:|:. :|:|     ||:...|:.|
Frog   254 GDGTRPEND---ERPAG----------EYEQPWEWKKEHIVRALSVQFENSE------------- 292

  Fly   766 YTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNW 830
                     |..||...||.||  |.|.....|.|...:..|. |.:| :||       |.:.:|
Frog   293 ---------RSPSKEEPGRSHQ--RQKSWTPKVLKQHQAEQGD-KVDP-TVP-------LEKQSW 337

  Fly   831 FAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSML 895
            :.|::.|:.|...|::....:||||....|.|     .|:::|||....: |:.:.|..:....|
Frog   338 YHGSVTRDQAESLLDSCPEASYLLRNSGSGNS-----KYSIALKTSQGCV-HIIVAQTKNNKFTL 396

  Fly   896 YCLSSRRHFKTIVELVSYYERNDL 919
            ..:...  |.:|.|:|.:|....|
Frog   397 SQMCGA--FNSIPEVVHHYSSQKL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	8/24 (33%)
		PH_Vav	624..753	CDD:269930	26/134 (19%)
		PH	641..749	CDD:278594	21/113 (19%)
		C1_1	761..804	CDD:278556	11/42 (26%)
		SH2_Vav_family	824..934	CDD:198193	25/96 (26%)
		SH3	940..993	CDD:302595
she	XP_004920075.1	SH2_SHE	335..432	CDD:198254	24/92 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910