DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and fgd1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_004914246.1	Gene:	fgd1 / 100489369	XenbaseID:	XB-GENE-6453246	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	641	Identity:	144/641 - (22%)
Similarity:	242/641 - (37%)	Gaps:	171/641 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 DGASNAVTPTPESYARQ------SQSPLAAAA---PSVPVSAAP-----GPPMGR-------LVS 314
            ||..:|||...|.:.|:      .::.|....   |.:..|.:|     |..||.       |:.
Frog   163 DGTPSAVTSLIEKFEREPIILPIERTTLGHGTDINPDMDSSPSPSLQHSGYSMGELGHKLLDLLE 227

  Fly   315 TSSSSSSLLVSESQRL------------QRAAAAVYNYRS-----SMASTEHEYAYIYSEDDE-- 360
            ...|..||  ...:||            |.:...:.|..|     |..||..|..:: .|.||
Frog   228 PEVSQGSL--ERRRRLGVEGGDAGEMGEQDSGGKLANRDSGIDSISSPSTSEEMCFL-GEVDEGG 289

  Fly   361 KVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQR 425
            :...:.||...|..:..:...|:...:|:| |......|.:  |.|..  |:|          |:
Frog   290 REESETCYSVAQRCSARDSEGDSDMEDGSG-DEGELPPERL--DPCEF--TAR----------QK 339

  Fly   426 DY-VIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRL-----------IFPRIRELVDIHT 478
            .| :..||:.||..|:..|..|...|...|     .||.|.           ||..|..:...|.
Frog   340 VYKIANELLQTEKAYVSRLHLLDQVFCARL-----MDEARTRASFPVEVVMGIFSNICSIYCFHQ 399

  Fly   479 KF----LDKLRESLTPNAKV-----KMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQI 533
            :|    |:|..:....|.::     |:|        ||| :|||:......|::.|....:::..
Frog   400 QFLLPELEKRMQEWDSNPRIGDILQKLA--------PFLKMYGEYVKNFDRAMELLNVWTERSSQ 456

  Fly   534 IDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLL-DKLVKETSPLHDDYR---SLERAKEAM 594
            ...::|:.:|:...|.|.|:..:..|:|||.:|.||| |.|:|    |.:|.:   ..|::.|.:
Frog   457 FKSVIQEVQREEACGNLTLQHHMLEPVQRIPRYELLLKDYLLK----LPEDSKDRCDAEKSLELI 517

  Fly   595 IDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQ-YGRLLLDGELHIKAHEDQKTK 658
            ...:::.|...|..:.:..:.||.:.:        |...|::. ...|:.:|.:...:.::..|:
Frog   518 ATAAEHSNAAIRKMERMHKLLKVYELL--------GGEEDIVSPTNELIKEGHILKLSAKNGTTQ 574

  Fly   659 LRYAFVF-DKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHS---RRTIGRDTRFKYQLLLA 719
            .||..:| |::|..|..|.:.  ..:|:.|...::....::.|.|   .||.
Frog   575 DRYLILFNDRLLYCVPKLRLI--GQKYSVRARIDVEGMELKHSSSPNLTRTF------------- 624

  Fly   720 RKSGK-TAFTLYLKSEHERDKWRKAL-------TEAMESLE------------PPGCQSTD---- 760
            |.||| .:..|..::|.|:..|.:|:       .:||||.:            ||...:||
Frog   625 RVSGKQRSLELQARTEEEKKDWIQAIEATINRHEQAMESCKLLCTSIREDEETPPNSPNTDLGKR 689

  Fly   761 -----HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQ 811
                 .:.|:      |.|..|.:.......:.:.||.|.   |..|    |:|.:
Frog   690 APTPIREKEV------TMCMKCQEPFNSITKRRHHCKACG---HVVC----GKCSE 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	50/199 (25%)
		PH_Vav	624..753	CDD:269930	31/153 (20%)
		PH	641..749	CDD:278594	26/119 (22%)
		C1_1	761..804	CDD:278556	9/42 (21%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
fgd1	XP_004914246.1	PHA03247	<6..207	CDD:223021	10/43 (23%)
		RhoGEF	341..525	CDD:238091	51/200 (26%)
		PH1_FGD1	557..664	CDD:275392	28/121 (23%)
		FYVE_FGD1_2_4	691..755	CDD:277280	11/55 (20%)
		PH2_FGD1-4	780..885	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910