DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and arhgef6

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_012825042.2	Gene:	arhgef6 / 100489192	XenbaseID:	XB-GENE-949773	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	984	Identity:	185/984 - (18%)
Similarity:	326/984 - (33%)	Gaps:	327/984 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSL-----DPREFNRKPQ 82
            :.|.||....|:....|.....|:  .|..:|:|||:||.|:..|.|..:     :|:
Frog     6 QTVTWLISLGVLSSPKKNICNPAD--FLKCSLKDGVVLCKLMNRLLPGFVSKVCTEPK------- 61

  Fly    83 MAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIG 147
             ::..|.:|||.||..|.   .:| .:||:|..||...||.:||.|||.:::..:
Frog    62 -SEEDCIENIKEFLKACS---ALR-VELFDPVDLYTGENFSKVLSTLSAVNRATE---------- 111

  Fly   148 FNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG 212
                 :||                               |......|.|||.|:...|.|
Frog   112 -----NPT-------------------------------SGRPCSGRLSQSHSIPACSQI----- 135

  Fly   213 TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
                     :|....|.:.:                     ::..|  .|||:   |.:|:...|
Frog   136 ---------NSQGTYCSTRV---------------------LKRQS--KALDM---TGNGSCQLV 165

  Fly   278 TPTPESYARQSQSPLA-AAAPSVPVSAAP--GPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYN 339
            .....::.:|::..|: ....::.||...  |...|.|...|....|..|.|
Frog   166 VKARFNFNQQNEDELSFCKGDTIYVSRVEDGGWWEGTLNGKSGWFPSNYVKE------------- 217

  Fly   340 YRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQD 404
                                           |::..||.......||
Frog   218 -------------------------------FKSNDKPLSPKAVKAC------------------ 233

  Fly   405 LCALHRTSRSQTASSTSFEQRDY---VIRELIDTESNYLDVLTALKTKFMGPLERH--LNQDELR 464
                      :||..|    ::|   |::.:::||.:|...|..|.:.::.||:.|  ::..::.
Frog   234 ----------ETAQLT----KNYYTVVLQNILETERSYAKELQLLLSTYLRPLQSHDKISTVDVS 284

  Fly   465 LIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADV 527
            .:.....|:..........|.| :..|....|:....|:....|: :|..:||....|:..|
Frog   285 SLLGNFEEICTFQQTLCQALEECAKLPENHQKVGGCLLNLFNQFMSLYLSYCSNHPMAVHVL--- 346

  Fly   528 CKKNQIIDQLVQKCERDYNVGK-----LQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSL 587
               .|..|:|....|   |.|.     |.|...||.|..|:.||..||.:|.:.....|.|::.:
Frog   347 ---TQQSDELGTFME---NQGAPVPGILMLTTSLSKPFIRLEKYVTLLQELERHMEEAHPDHKDI 405

  Fly   588 ERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAH 652
            .:|..|...:.....::::...  :.:|.:.:||      |...|.|:...|..:...::.::..
Frog   406 LKATAAFKTLVTQCQDLRKRKQ--LELQILSESI------QGWEGEDIKTLGTAVFMSQVMVQCG 462

  Fly   653 EDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQL- 716
            .:::.:.||..:|...|:|:.|....:|   :.|:....|....|.:.....|    |...:::
Frog   463 TNEEKEERYFMLFPNALLMLSASPRMSG---FIYQGKLPLTGMSVVKLEENDT----TNHGFEIA 520

  Fly   717 --LLARKSGKTAFTLYLKSEHERDKW------------------------------RKALTEAME 749
              ::.|      ..:|..:.|:..:|                              ||.|..:..
Frog   521 GTMIER------IVVYCNNSHDCQEWLEHLHRLTKGTGSHASLCKTQSLTSTSLTERKQLPPSHY 579

  Fly   750 SLEPPG--------------C----------QSTDHKMEI-YTF-DAPTTCRHCSKFLKGRIHQ- 787
            |:.|.|              |          .:..:|..: |.| |:..:.::..|||..|..:
Frog   580 SVTPRGPLEPAKLYKAWTLSCLRPAPPLRPSYALGYKERMSYIFKDSSKSPKNVKKFLPKRKTER 644

  Fly   788 -------GYRCKVCQISVHKGCISSTGRCKQNP--VSVPPPVCDRQLSEFNWFAGNMDRETAAHR 843
                   |:|             .||...:::.  :.|....|.....:.:..:|:. :::.|..
Frog   645 KPSDEDSGFR-------------KSTVALEEDAQILKVIEAYCTGAGFQQSLCSGSR-KDSVAQV 695

  Fly   844 LENRRIGTYLLRVRPQGPSTAHE-----TMYALSLKTDDNVIKHMKINQENSGDSMLYCL----S 899
            |........:..:|..|.:.:.|     |:|||.    |.|   |::.|||.  .|..||    .
Frog   696 LLLEEENLIIDELRTNGQTVSEEKSLVDTVYALR----DEV---MELKQENK--RMKQCLDEEQK 751

  Fly   900 SRRHFKTIV 908
            ||:..:.||
Frog   752 SRKELEKIV 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	37/113 (33%)
		RhoGEF	428..603	CDD:279015	42/183 (23%)
		PH_Vav	624..753	CDD:269930	24/161 (15%)
		PH	641..749	CDD:278594	19/140 (14%)
		C1_1	761..804	CDD:278556	10/52 (19%)
		SH2_Vav_family	824..934	CDD:198193	23/94 (24%)
		SH3	940..993	CDD:302595
arhgef6	XP_012825042.2	CH_alphaPIX	1..117	CDD:409114	40/170 (24%)
		RhoGEF67_u1	115..161	CDD:406911	15/85 (18%)
		SH3_alphaPIX	163..220	CDD:212993	13/100 (13%)
		RhoGEF	243..420	CDD:238091	42/185 (23%)
		PH_Cool_Pix	452..549	CDD:269932	16/109 (15%)
		RhoGEF67_u2	578..685	CDD:374671	18/119 (15%)
		betaPIX_CC	688..774	CDD:406829	22/83 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910