DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and plekhg1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_017949742.1	Gene:	plekhg1 / 100488098	XenbaseID:	XB-GENE-6050489	Length:	1563	Species:	Xenopus tropicalis

Alignment Length:	525	Identity:	124/525 - (23%)
Similarity:	224/525 - (42%)	Gaps:	132/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 STSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDE------------KVYED- 365
            |||||:||          |.:...:..|.::||..|  ..::.:|.|            ::..|
Frog    70 STSSSASS----------RDSHCSFGSRMTLASNSH--LGLFHQDKEAGAIKLELVPARQISNDD 122

  Fly   366 ---LCYVTFQAKAKP-----EVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSF 422
               :|     .|.:|     |..:|.       :..|..|.|......|::  |...:| :|...
Frog   123 LHRIC-----TKEQPHGSPREKPSDE-------HQSTQWKAEAKRSIKCSV--TEAVET-TSPKL 172

  Fly   423 EQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLN--QDELRL---------IFPRIRELVDI 476
            ...|.|::|::.||..|:..|.::       :|.:||  .|:.||         :|..|.::...
Frog   173 MYVDRVVQEILHTERAYVQDLKSI-------VEDYLNCISDQSRLSLGTEERSALFGNICDIYHF 230

  Fly   477 HTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKC 541
            :::.|.:|..  ..|..|.:|:.|:...|.|.||.::|:....::..|.: |.:|:|:.:..::
Frog   231 NSELLQELEN--CDNDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAILTE-CMRNKILAKFFRE- 291

  Fly   542 ERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR 606
            .::.....|.|...|..|:||||||||||.::........:.|..:..|.:.|..|:.:||::||
Frog   292 RQEVLQHSLPLGSYLLKPVQRILKYHLLLHEISNHLDKDTEGYDIVLDAIDTMQRVAWHINDMKR 356

  Fly   607 DSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIM 671
            ..:|.:.:|:::.      ||.|..|.||..||.|:|:|....:..::::|    .|:||::|::
Frog   357 KHEHDIRLQEIQS------LLTNWKGPDLTSYGELVLEGTFRFQRAKNERT----LFLFDRLLLI 411

  Fly   672 VKALHIKTGDMQYTYRDSH----NLADYRVEQSHSRRTIGRD----TRFKYQLLLARKSGKTAFT 728
            .     |..|..|||: :|    ||....|        |.::    :.|.|      |:.|...|
Frog   412 T-----KKRDDTYTYK-AHILCCNLMLVEV--------IPKEPLSFSVFHY------KNPKLQHT 456

  Fly   729 LYLKSEHERDKW--------------------RKALTEAMESLEPPGCQST---DHKMEIYTFDA 770
            :..||:.::..|                    ::|:.| |:::..||...|   :.|..:...:.
Frog   457 VQAKSQQDKRLWILHLKRLILENHPAKIPAKAKQAILE-MDAIHHPGFSYTPEGERKSPLNLKED 520

  Fly   771 PTTCR 775
            ..:||
Frog   521 LASCR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/185 (26%)
		PH_Vav	624..753	CDD:269930	37/156 (24%)
		PH	641..749	CDD:278594	28/135 (21%)
		C1_1	761..804	CDD:278556	3/15 (20%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
plekhg1	XP_017949742.1	RhoGEF	176..352	CDD:238091	48/186 (26%)
plekhg1	XP_017949742.1	PH_PLEKHG1_G2_G3	334..479	CDD:270063	44/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030