DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and tiam2a

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009291563.1	Gene:	tiam2a / 100334442	ZFINID:	ZDB-GENE-030219-98	Length:	1686	Species:	Danio rerio

Alignment Length:	1030	Identity:	202/1030 - (19%)
Similarity:	357/1030 - (34%)	Gaps:	295/1030 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SNSFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQ--------PDAEIRILAMTLR-------- 55
            ||::|.|.........:...|:|..      |.|:.        .:..:|:|...:|
Zfish   573 SNTYGDVYLFQASSQTDLENWVTAI------HSASASLFAKRYGKEDTLRLLRGQIRGLLQKIDM 631

  Fly    56 DGVL--LCNLVIHL--DPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTML 116
            ||.:  :..|.:.:  ||.:....| |:..|..|.|...|:.||...|: ...::..:|..|..|
Zfish   632 DGKMKKMAELQLSVVGDPKNRKAIE-NQIQQWEQNLERFNMDLFRMRCY-LASLQGGELPNPKSL 694

  Fly   117 -----------------YDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAI 164
                             :.:::||.::.:..:.:..::             .||.:.|..|.:.:
Zfish   695 LATASRRTKAALARLGIFSVSSFHALICSRDEATMRKR-------------SLSLSHRGRSKKGV 746

  Fly   165 YKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIE------DS 223
            :..|...|...::......|.|.........|.|| |.:..|   .:|...::....      .|
Zfish   747 FSSLKGLDTLTKRGHEKKHSLSQDLSELSCCSYSG-LPQVFD---SDGGAQLNSVTHCSFKRLGS 807

  Fly   224 LSNMCDSTIDNDAE-DAGVETP---LLSDCQGSHVRELSFDLALDVVSST--------------- 269
            |:|:........:: |...|:.   .:.:||...|...|....:||::.|
Zfish   808 LTNVYSIVPPEGSQWDCSRESTTCIYMPNCQTVTVLLKSHHTVMDVLAETCMLVGLDPSTHCLRL 872

  Fly   270 -----------TDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVS---TSSSSS 320
                       |..|...:...|......||..:.....|.|....   ..|..|:   .|..:|
Zfish   873 RRFTGDKMEISTPSAHELLQGLPYDELEVSQLQVYTLHMSRPSLTG---DFGFAVTGYVDSLKNS 934

  Fly   321 SLLVSE--------SQRLQRAAAAV------------------YNYRSSMASTEHEYAYIYSEDD 359
            .::|||        |:.|:.....|                  :|.::...:.:.....|..:.|
Zfish   935 HIIVSEVLPDGLAFSKGLRPGDEIVVLNGCEVSSLDLTLIQTLFNEQNLQLTAKRHLPSIPHDSD 999

  Fly   360 ----EKVYEDLCYVTFQAKAKPEVT--TDNIACN----GTGYDHTNTKEEEVYQDLCALH----- 409
                :..|.|:.....:||:..:|:  |:.::.|    .:.::|......:....:|:|:
Zfish  1000 TANVQSPYRDIHQNRQRAKSSTDVSCVTETLSVNDGLQDSYHNHRQVHHSKSVDTVCSLYHSYQE 1064

  Fly   410 ------RTSRSQTASS-----------TSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERH 457
                  .:...||...           ::.|:...||:||:|||.:|:..|..|...::.||::.
Zfish  1065 GSGGLMESQEEQTGPEPAILRPCPRHMSATERLRKVIQELVDTEKSYVKDLNCLFEIYLKPLQKE 1129

  Fly   458 --LNQDELRLIFPRIRELVDIHTKFLDKLRE--SLTPN-----AKVKMAQVFLDFREPFLIYGEF 513
              |.|||:..:|..:.|::|....||..|.|  |.:||     ..|:..::.......||.|.|.
Zfish  1130 TFLTQDEMESLFGSLPEMLDFQKVFLQTLEEKISSSPNFNTFETPVQFKKLLFSLGGSFLYYAEH 1194

  Fly   514 CSLLLGAIDYLADVCKKNQIIDQLVQKCERDY-------NVGK---LQLRDILSVPMQRILKYHL 568
            ..|..|   :.|:..|..:::::  .|.:|.:       |..|   ..|...|..|:||:|||.|
Zfish  1195 FKLYSG---FCANHIKVQKVLER--AKTDRSFKEFLDARNPTKQHSTTLESYLIKPVQRVLKYPL 1254

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR-------DSDHLVIIQK-VKDSICDIH 625
            ||.:||..|....:::..|..|.:.|..|:.:|||:::       ..|.||..|. .:..:.:|.
Zfish  1255 LLRELVSLTDTDSEEHYHLTEALKEMEKVASHINEMQKIYEDYGAVFDQLVAEQSGTEKEVTEIS 1319

  Fly   626 LLQNGNGSDLL------QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQY 684
            :.|....|.::      ..||:..|.||.:             |||.:.:|::
Zfish  1320 MGQFLMHSSVIWLNPFPSLGRMKKDPELTV-------------FVFKRAVILL------------ 1359

  Fly   685 TYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLL-----LARKSGKTAFTLYLKSEHERDKWRKAL 744
             ||:::.:   |.:...||...|....||::.|     |..:.|.||.|..|        |....
Zfish  1360 -YRENNKV---RKKMVTSRSAHGDQDSFKFRWLIPLSALQVRLGNTADTDCL--------WELIH 1412

  Fly   745 TEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRC 809
            |::.:...|.                                          :|.:.| |||..|
Zfish  1413 TKSQKEGRPE------------------------------------------TVFQLC-SSTPEC 1434

  Fly   810 KQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTA 864
            |.|.:.|...:....|..      ||.|...:.|...:|    |..:|...|::|
Zfish  1435 KVNIIKVMRSILRENLRR------NMQRVEQSERTCKKR----LTPLRKSLPASA 1479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	26/148 (18%)
		RhoGEF	428..603	CDD:279015	58/193 (30%)
		PH_Vav	624..753	CDD:269930	29/139 (21%)
		PH	641..749	CDD:278594	24/112 (21%)
		C1_1	761..804	CDD:278556	2/42 (5%)
		SH2_Vav_family	824..934	CDD:198193	10/41 (24%)
		SH3	940..993	CDD:302595
tiam2a	XP_009291563.1	PH1_Tiam1_2	488..613	CDD:269937	8/45 (18%)
		UBQ	829..904	CDD:320785	11/74 (15%)
		PDZ_signaling	906..986	CDD:238492	13/82 (16%)
		RhoGEF	1100..1289	CDD:214619	58/193 (30%)
		PH2_Tiam1_2	1291..1458	CDD:269957	47/252 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910