Protein Alignment Vav and vav3

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_073797007.1
• Gene: vav3 / 100333179
• -ID: -
• Length: 860
• Species: Danio rerio
• Alignment Length: 1100
• Identity: 283/1100 - (25%)
• Similarity: 446/1100 - (40%)
• Gaps: 376/1100 - (34%)

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            ||:|..||..|||:||:|:.....|::..||.|||||||||.|:.:|.|.|::.||.|.:|||:|
Zfish     7 WRQCALWLINCKVLPPNHRVTWESAQVFDLAQTLRDGVLLCQLLNNLRPQSINLREINLRPQMSQ 71

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||..|...||::.::|||...|:|:.:|.:|:.||||||.....||.       .:
Zfish    72 FLCLKNIRTFLHACSEIFGMKKSELFEAFDLFDVRDFGKVMDTLSKLSHTHIAQQT-------GI 129

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
            :..|||.|..||.||..|                                    .|:..|||.||
Zfish   130 RPFPTEESVEDEDIYNHL------------------------------------EDLIDENGVED 158

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
            .:|                           |.||
Zfish   159 EED---------------------------LYDC------------------------------- 165

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
                                                                    ||
Zfish   166 --------------------------------------------------------VY------- 167

  Fly   346 STEHEYAYIYSEDDE--KVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
                       :|||  :|||||..|.. .:.:.:..||..:|                   |
Zfish   168 -----------DDDEGGEVYEDLMKVEL-VQPQKQAETDIRSC-------------------C-- 199

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIREL 473
                                :.|:..||..|.:.|.:::..||.||.:.|:..|:..:|..|.:|
Zfish   200 --------------------LMEIKQTEEKYTETLDSIEKFFMKPLGQSLSSVEIEKVFINIPDL 244

  Fly   474 VDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
            |.:||..|.::::|:..:....:.|:|:.::|..::||::||.:..||..|.|:||..:.:.|::
Zfish   245 VKVHTSLLREVQDSVLMHNATNLYQIFIKYKERLVLYGKYCSQVESAIACLDDICKNREDVRQML 309

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHD--DYRSLERAKEAMIDVSQYI 601
            :.|.:..|.||..|||:|.|||||:|||||||.:|||.|   ||  |..:|.:|.:||.|::||:
Zfish   310 ELCSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT---HDATDKTNLRQALDAMKDLAQYV 371

  Fly   602 NEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFD 666
            ||||||.:.|..|.:.:.||      :|.|.| |..|||...|.|:.:.:.:.:..:.|:.|:||
Zfish   372 NEVKRDIETLRDIDQYQKSI------ENLNQS-LRNYGRPKGDSEVRVASVDKRAKQDRHIFLFD 429

  Fly   667 KILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYL 731
            ..:|:.|    :.|| .|..::..:|..:::..:.:.....|  ::.:...|....|:..|..:.
Zfish   430 SAVIVCK----RRGD-NYEMKEVIDLHSFKITNNPTSEKENR--KWCHGFYLTHNQGQNGFEFFF 487

  Fly   732 KSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQI 796
            |::..:.||::....|:.::.|...:...|:..::||:..|:|..|...|:|..:|||||..|..
Zfish   488 KTKELKKKWQEQFGMALSNICPESGKCNFHEFRMHTFETTTSCSSCEMLLRGVFYQGYRCSKCGA 552

  Fly   797 SVHKGCI---------SSTGRCKQNPVS------------------------------------- 815
            ..||.|:         |:..|..::.:.
Zfish   553 GAHKECLGRVEVCVKSSAASRSAESQIGKTTSRGDKDLPKMLVICNYHGSPSPPNGPPLNINSGD 617

  Fly   816 -------------------------------------VPPPVCDRQLSEFNWFAGNMDRETAAHR 843
                                                 ||.||   ..|...||||.|:|..|...
Zfish   618 VIELIEANVHSTWWKGKVLATKEVGLFPRDAVKPFPCVPKPV---DYSSQLWFAGPMERVQAEAA 679

  Fly   844 LENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIV 908
            |.|:|..||::|.|.:   ..||  ||:|:|. .|.:||:||..::.    |:.::..|.|.:|:
Zfish   680 LLNKRSSTYMVRHRSR---EFHE--YAISIKY-KNDVKHIKILTKDG----LFYIAENRKFSSIL 734

  Fly   909 ELVSYYERNDLGENFAGLNQSLQWPYKEV------------------------------------ 937
            :|:.||:.:.|.|.|..|:.:|::.|:|.
Zfish   735 DLIQYYKIHSLREGFRTLDTTLKFAYREPENGANNPLLCGLSFLTPAGYSFVPPSTTPFWSVFSQ 799

  Fly   938 ----IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
                :|.|.||:.|: .:.:|.::....|.:..|.|.| |||:|::...||:||..||:|
Zfish   800 KGIGVAIARYDFSPR-DTRELSMQEGDVVRIYSKTGAS-GWWKGEVNGRVGWFPSTYVEE 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	58/113 (51%)
		RhoGEF	428..602	CDD:459876	67/175 (38%)
		PH_Vav	624..753	CDD:269930	27/128 (21%)
		C1_VAV	759..810	CDD:410360	19/59 (32%)
		SH2_Vav_family	824..934	CDD:198193	38/109 (35%)
		SH3	940..993	CDD:473055	19/52 (37%)
vav3	XP_073797007.1	None