Protein Alignment Vav and fgd5a

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_001919894.2
• Gene: fgd5a / 100151562
• ZFINID: ZDB-GENE-090428-3
• Length: 1473
• Species: Danio rerio
• Alignment Length: 1140
• Identity: 226/1140 - (19%)
• Similarity: 374/1140 - (32%)
• Gaps: 399/1140 - (35%)

  Fly    60 LCNLVIHLDPSSLDPREFNRKPQMA-QFLCSKNIKLF------LDVCHNNFGIRDADLFEPTMLY 117
            |||:.:   |:.||   ..|.|::. :.:.:...:.|      || ||......|:|......:|
Zfish   425 LCNITV---PADLD---LGRTPELTNRVVFAHTTEAFEEDIEELD-CHIVPFFEDSDTESDEHIY 482

  Fly   118 DLTNFH---RVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTE-----RSH--------------- 159
            :...|.   ...|:|.:.|...:.:.|...:.|:..:..|.|     :||
Zfish   483 EEAGFDSEGENFISLDRKSIVTRSRSLSGKVPGYVPETVPEETGTEYQSHDYYTVALDQNGDPHP 547

  Fly   160 --SDEA----IYKDL--------------HSTDLNM-----------------RK--TSSIDASA 185
              ||||    |...|              ...||.:                 ||  |.|:....
Zfish   548 KPSDEAEANRIIPSLKPRRFLLSPRSLSVEGRDLQLSGHFEGEKSLREEYRLQRKDDTLSLPCVI 612

  Fly   186 SSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIE-------------DSLSNMCDSTIDNDAE 237
            :||..:..|:.||     :|.::......||....|             .||....||. ||..:
Zfish   613 TSSGSFSQRSHQS-----SSGVSTPTSLVDIPPPFELAYITKRPVTKSSPSLLIQHDSP-DNPKK 671

  Fly   238 -----------------------DAGVETPLLSDCQGSH---VRELSFDLALDVVSSTTDGA--- 273
                                   |..|.:. .|..:.||   :|.|..|      ..:|.|:
Zfish   672 KKTSFKRFLALKFRKKSESKSRGDGSVRSS-RSSSESSHHGPIRVLELD------RRSTSGSPKL 729

  Fly   274 -SNAVTP-----TPESY----ARQSQSPLAAAAPSVPVSAAPG------PPM-------GRLVST 315
             |:|..|     .|.::    .|||:.....:..|..:|....      ||.       .|.:|.
Zfish   730 QSHAGKPQRNSEIPTTFLLYKERQSRQGALKSYNSRGISRVESFEDRTRPPFMPLPLTKPRSISF 794

  Fly   316 SSSSSS------LLVSESQRLQ----RAAAAV--------YNYRSSMASTEHEYAYIYS------ 356
            .|:.:|      .:.|:.:.:|    |...||        :|..::.|:....|..:.|
Zfish   795 PSADTSDYENIPAMSSDYENIQIPHGRPTRAVTITEFFDDHNRTAAPANENDGYVDMNSFAGIEN 859

  Fly   357 ------EDDEKVYED---LCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTS 412
                  :|.|..|.:   :|.|:        .|..|      ..||..|.|||   |.|..|...
Zfish   860 KSTTREQDTESAYTEPFPVCPVS--------ATVSN------EEDHGRTSEEE---DGCGDHCHD 907

  Fly   413 RSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFM----------GPLERHLNQDELRLIF 467
            |.....|.::    ||.::|:|:|..::..|..|:..|.          |||..:...||   ||
Zfish   908 RQIDGRSRAY----YVAKDLVDSEREHVKALKVLQEDFRAAVESGGDDNGPLIENGKLDE---IF 965

  Fly   468 PRIRELVDIHTKFLDKLRESLTPNAKVK-------MAQVFLDFREPFLIYGEFCSLLLGAIDYLA 525
            ..:.:...:|::.|::|      ..::|       :..|.|..|..|..:..:.|....::..|.
Zfish   966 STLPQAYSLHSEILNEL------ETRIKQWEDSPTVVDVILTRRAEFSSFATYISNYDRSMSVLD 1024

  Fly   526 DVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQ--------RILKYHLLLDKLVKETSPLHD 582
            :.|:|:|..:.:|::.|.....|.|       ||::        |||:|.:||...:...||...
Zfish  1025 ESCRKSQAFEDVVKQFETQNAEGVL-------VPLKHQLLRVIVRILQYRMLLTDYLNNLSPDSK 1082

  Fly   583 DYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGS-DLLQYGR------ 640
            :|...:.|...:.:|:..:|:..:..::|:.:         :|:..:..|. ||||.||
Zfish  1083 EYEDTQAALVIVSEVADQVNDNLKHGENLLRL---------VHIDYSVRGKRDLLQPGRVFVKEG 1138

  Fly   641 ----------------LLLDGELHIKAHEDQKTKLRYAF----------VFDKILIMVKALHIKT 679
                            |:.|..|:....:|.|.:|:...          :.|.:|   ..|.|:.
Zfish  1139 TLMKVSRKSRQPRHLFLMNDVMLYTYPQQDGKYRLKNTLTLSGMKVSKPIIDNVL---NTLRIEV 1200

  Fly   680 GDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKAL 744
            .|:..|.               |..::|....:.:.|..|..........:..|...|:|...:|
Zfish  1201 SDVTITL---------------SASSLGEREDWFHTLSRAIADHAAGLNTFSSSSEAREKLWMSL 1250

  Fly   745 TEAMESLEPPGCQSTDHKMEIY--TFDAPTT-------------CRHCS------KFLKGRIHQG 788
            .||...|.|     ..|.|...  |.|...|             ||.||      |:||.|:.:
Zfish  1251 GEAAPVLVP-----VSHVMMCMNCTSDFSLTLRRHHCNACGKVVCRSCSRNRYPLKYLKDRMAK- 1309

  Fly   789 YRCKVCQISVHK---------GCISSTGRCKQNPVSV------PPPVCDRQLS-----------E 827
             .|..|...:.|         |.:|........|:|.      ||.:...:.|           |
Zfish  1310 -VCDHCYAELRKRGGDVPGSCGSVSPRTHRASRPLSAVFQSLQPPSLWRNRKSSSPLTQVSVGAE 1373

  Fly   828 FNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKH--------MK 884
            .:..:|::.|...:.|...|.  .:||:         .:.:|....: :|.|...        :|
Zfish  1374 GSTMSGSLQRRKKSKRRWKRL--WFLLK---------DKVLYTFKAR-EDKVASESLSLQGFTVK 1426

  Fly   885 INQENSGDS-----MLYCLSSRRHFKTIVELVSYY 914
            ::..:.|:.     .||      |.||:     ||
Zfish  1427 LSDRSEGEDTDNVFQLY------HKKTL-----YY 1450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	19/81 (23%)
		RhoGEF	428..603	CDD:279015	44/199 (22%)
		PH_Vav	624..753	CDD:269930	31/161 (19%)
		PH	641..749	CDD:278594	22/117 (19%)
		C1_1	761..804	CDD:278556	17/72 (24%)
		SH2_Vav_family	824..934	CDD:198193	20/115 (17%)
		SH3	940..993	CDD:302595
fgd5a	XP_001919894.2	FYVE_FGD5	1255..1321	CDD:277281	17/72 (24%)
		PH2_FGD5_FGD6	1377..1467	CDD:270057	18/97 (19%)
		DnaJ	<25..149	CDD:333066
		RhoGEF	919..1103	CDD:214619	44/199 (22%)
		PH1_FGD5	1121..1243	CDD:275435	24/139 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910