Protein Alignment Vav and mcf2l2

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_073772492.1
• Gene: mcf2l2 / 100149630
• ZFINID: ZDB-GENE-100812-1
• Length: 1284
• Species: Danio rerio
• Alignment Length: 1113
• Identity: 217/1113 - (19%)
• Similarity: 374/1113 - (33%)
• Gaps: 356/1113 - (31%)

  Fly    18 GDLWRECV---AWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNR 79
            |:....|:   |......::.||....|...| |:||                   .||..|
Zfish   288 GNTLLSCIKDQATKAESHILNPDEVENQTTVE-RLLA-------------------QLDETE--- 329

  Fly    80 KPQMAQFLCSKNIKL--FLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQC-RKVQQL 141
             ....||....::||  .|.:.|.....::..:       .|......|:.||....| .:|:||
Zfish   330 -NAFEQFWSRHHLKLEQCLQLRHFEQDFKEVKV-------SLDGLSEALLGLSDTGDCVARVEQL 386

  Fly   142 HPDLIGFN------LQLSPTERSHSDEAIYKDLHSTD------LNMRKTSSIDASASSSAEYYDR 194
            ..:|....      |:.:..:..|.|:.|..:.::.|      :.:|:.  .|..::.:.:..|.
Zfish   387 LGELKTLEDKAQECLEKAQLQAQHGDQLIQSNHYAIDSIRPKCVELRRI--CDDFSNEAKKKRDV 449

  Fly   195 TSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPL---------LSDCQ 250
            .::|        :.|....::::.:.|..:..:....:|......|.|..|         ..:.|
Zfish   450 LTKS--------LEILKRIDEVNQWCESGVYLLASQAVDRCQTQEGAEAALQDIERYMKTAKEQQ 506

  Fly   251 GSHVRELS--FDLAL-DVVSSTTDGASNAVTPTPESYARQSQS----------PLAAAAPSVPVS 302
            .||::||:  :::.| :::.|....|...:....|.:.::..|          |:...||. |.|
Zfish   507 LSHLKELNNQYEVVLSELLKSKVQTALKTLNDVQEMFEKRHASLKKLSTKQTRPVQPVAPR-PES 570

  Fly   303 AA---------PGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSED 358
            :.         |.||.....:|.:||::...|:::..:|.     |.|
Zfish   571 SPKRPSPKIPHPTPPTSHRKTTDNSSTNRQPSDAELAKRK-----NIR----------------- 613

  Fly   359 DEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFE 423
                           |||..:..:.:...|.|               .:.|....::|..|.| .
Zfish   614 ---------------KAKGGIKIEVMHEGGQG---------------GSSHILMNNETEESLS-N 647

  Fly   424 QRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDEL------------RLIFPRIRELVDI 476
            :|.:::.|||:||..|::.|.::...:...|:    ..||            .::|..:.|:...
Zfish   648 RRSHIMNELIETERLYVEELQSIIEGYAAALD----DPELIYLIPPSLENKKEVLFGNLPEIYQF 708

  Fly   477 HTK-FLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQK 540
            |.| ||.:|..|......|  ...||..:|...||.::|.....: :.|...|..:...    |:
Zfish   709 HQKIFLKELENSAEKPELV--GTCFLKRKEELQIYEKYCQNKPRS-EALWRQCGDSMFF----QE 766

  Fly   541 CER--DYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE 603
            |::  |:   ||.|...|..|:|||.||.|:|.:::| .|...:....||.|:..::|:.:.:|
Zfish   767 CQKRLDH---KLSLDAYLLKPVQRITKYQLMLKEMLK-CSKNPEGTAELEEAQATVLDIIKSVN- 826

  Fly   604 VKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGEL-----HIKAHEDQKTKLRY-- 661
               ||.|.:.|...:.|:.|:              |:||:.|..     |.|.|...|...|:
Zfish   827 ---DSMHQIAITGFEGSLNDL--------------GKLLMQGSFNVWTDHKKGHSKVKDLARFKP 874

  Fly   662 ----AFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKS 722
                .|::.|:::..|    |..:|    .|.|       |:|.|       ..||:.|    |.
Zfish   875 MQRHLFLYHKMILFCK----KREEM----TDGH-------EKSPS-------YSFKHSL----KM 913

  Fly   723 GKTAFTLYLKSEHER-DKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPT-------------- 772
            |....|..:|.:.:: :.|...                  :.|:|...||:
Zfish   914 GSVGITENVKGDIKKFEIWYNG------------------REEVYIIQAPSMDVKNTWVSEIRKV 960

  Fly   773 ------TCRHCSKFLKGRIHQGYRCKVCQISVHKGC--ISSTGRCKQNPVSVPPPVCDRQLSEFN 829
                  .||..|     ::||    |:.:...|...  :..|. .:|:..|.|.....|..|..|
Zfish   961 LTSQLEACREAS-----QLHQ----KITENIYHAPMRNMRKTA-LRQSDSSSPETGYRRSDSGPN 1015

  Fly   830 W------FAGNMDRETAA--------HRLENRRIGTYLLRVRPQ----------------GPSTA 864
            .      .:.::..|.||        ..|.|||    .|...|.                |.:||
Zfish  1016 MRQKRADASSSLGSERAALPRKRFTLQGLSNRR----SLPAEPAPKETEVTRRFSLASTVGSATA 1076

  Fly   865 HETMYALS---------LKTD------DNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYY 914
            ..|...||         :|:|      :...|.....:|...||    |.:.|..|
Zfish  1077 PRTKAPLSSSLKSKRHQIKSDPTPFGYEGATKTRGFKKETMRDS----LPAERKSK--------- 1128

  Fly   915 ERNDLGENFAGLNQSLQ--WPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRG 977
              ...|...|....:.|  |..:.:.:....|:|        .:.:..:.|.|..||:.:|  ..
Zfish  1129 --GSGGSKPAVPRSASQPGWSQRRLPSMDAEDFE--------TIPSSAEELSISSDGEDEG--HN 1181

  Fly   978 KIGDTVGY 985
            |.||...|
Zfish  1182 KNGDNDRY 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	22/120 (18%)
		RhoGEF	428..602	CDD:459876	48/188 (26%)
		PH_Vav	624..753	CDD:269930	27/140 (19%)
		C1_VAV	759..810	CDD:410360	12/72 (17%)
		SH2_Vav_family	824..934	CDD:198193	30/156 (19%)
		SH3	940..993	CDD:473055	11/46 (24%)
mcf2l2	XP_073772492.1	None