Protein Alignment Vav and si:dkey-65j6.2

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_009295405.2
• Gene: si:dkey-65j6.2 / 100148904
• ZFINID: ZDB-GENE-090313-319
• Length: 1588
• Species: Danio rerio
• Alignment Length: 567
• Identity: 126/567 - (22%)
• Similarity: 211/567 - (37%)
• Gaps: 162/567 - (28%)

  Fly   222 DSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT-----------DGASN 275
            |..:..||:|...|.|...|..   |:.:.:..|        |.:.:|.           |..:.
Zfish   960 DWTTGQCDATALEDEERECVPE---SETRANRSR--------DSIHNTVTCFNFRSKPRRDSKNT 1013

  Fly   276 AVT-PTPESYARQSQSPLAAAAPSVPVSAAPGPPMG-------RLVSTSSS-SSSLLVSESQRLQ 331
            |.| .||...:::.:|....|||.  ..|..|.|:|       ..|:.||| .|.|.::|.  :|
Zfish  1014 ATTRETPADCSQRGRSSSRRAAPE--QRAVSGAPVGCQWFPWQNTVNRSSSRRSELHITEP--IQ 1074

  Fly   332 RAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNT 396
            |        .:|.:|..|:                              |...|....|.:..:|
Zfish  1075 R--------HNSFSSQTHD------------------------------THGDAWRNEGENTADT 1101

  Fly   397 KEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQD 461
            .|.           .|||...      ||  ::.||:.||..|:..|..:.|.:...|.|.....
Zfish  1102 HES-----------PSRSMKL------QR--IMEELLLTEVEYVRSLGYILTHYYPLLSRPDVPQ 1147

  Fly   462 ELR----LIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAID 522
            :||    .||..:.:|.|.|.:...:..::.... .::..:.||:.||.|.:|..:
Zfish  1148 DLRGQRGRIFGNLEKLYDFHCQHFQQELQACQAE-PLRAGRCFLNHRESFGLYALY--------- 1202

  Fly   523 YLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSV------PMQRILKYHLL----LDKLVKET 577
                 .|.....|.|:|. .|.:...:|:|.|.:.:      |:|||.||.||    ||:.|.:.
Zfish  1203 -----SKNKPQSDALIQH-HRYFKRKQLELGDSMDLSSYLLKPVQRISKYSLLLQEILDECVSDQ 1261

  Fly   578 SPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLL 642
            ||..::.       :|.::|.::  :::..:| |:.:..::|  ||::|.:.         |:|:
Zfish  1262 SPEREEI-------QAALEVVRF--QLRHGND-LLTMDAIRD--CDLNLNEQ---------GQLI 1305

  Fly   643 LDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHS----- 702
            ...|..:...  :|..||..|:|..:::..|......||..|.|:.|....:..:.||..
Zfish  1306 RQDEFWVIFR--KKRSLRRVFLFQDVILFTKTKKNDRGDDVYVYKLSIKTCEIGMTQSCGLSGRS 1368

  Fly   703 -----RRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKAL 744
                 ||...:||   |.|....:..|.|:|    ::.|...|.:||
Zfish  1369 FEIWFRRRRSQDT---YILQAETRDIKHAWT----TDLEHILWEQAL 1408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	45/188 (24%)
		PH_Vav	624..753	CDD:269930	30/131 (23%)
		PH	641..749	CDD:278594	28/114 (25%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
si:dkey-65j6.2	XP_009295405.2	SPEC	634..>803	CDD:321951
		RhoGEF	1114..1283	CDD:306973	45/193 (23%)
		PH_puratrophin-1	1276..1411	CDD:270062	35/156 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910