DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and mcf2la

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_021332781.1	Gene:	mcf2la / 100148439	ZFINID:	ZDB-GENE-090312-122	Length:	1221	Species:	Danio rerio

Alignment Length:	1025	Identity:	206/1025 - (20%)
Similarity:	350/1025 - (34%)	Gaps:	325/1025 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 SKLSQCRKVQ---------QLHPDLI-----GFN-LQLSPTERSHSDEAIYKDLHSTDLNMRKTS 179
            :||.||.:::         :.|.||:     ||: :.:||....|    |.|:|  |:...|.:.
Zfish   343 TKLEQCLQLRHFEQNFREVRAHLDLVYDRLSGFSEVGISPAHAEH----ILKEL--TNHEERASE 401

  Fly   180 SIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIE--DSLSNMCD--STIDNDAEDAG 240
            .:|              |:.||..::|..||.....:|..:.  ..|.::|:  |||....:...
Zfish   402 VMD--------------QALSLASDADQLIEASHYAVDSILPKCSELRSVCEEISTILRAKKAYL 452

  Fly   241 VETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAP 305
            .::..|..|                :...|....:.:      |...||
Zfish   453 FKSVELHQC----------------LEKATKWYDDGI------YLLASQ---------------- 479

  Fly   306 GPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYR-SSMASTEHEYAYIYSED----DEKVY-- 363
              |:.:..|...:.|:|     |.::|.......:: :.:.....:|..:.::|    .:||:
Zfish   480 --PVDKCQSQDGAESAL-----QEIERYLDTANQHKLTDLNGIWRDYDSVLTQDFRDQVDKVFQK 537

  Fly   364 ---------------------------------EDLCYVTFQAKAKPEVTTDNIACNGTGYDHTN 395
                                             |.:......:.|..|.:.:....||      |
Zfish   538 QLSMQEMFEKRRVSLKKLAAKQTRPVQPVAPRPEAIIKTPVSSPAHREKSIEGDVING------N 596

  Fly   396 TKEEEVYQDLCALHRTSRSQTASSTSFEQ-----RDYVIRELIDTESNYLD----VLTALKTKFM 451
            .|:.|::     |.....|:..|.:..|:     |.:|:.||::||..|::    ||.....:..
Zfish   597 CKKGELH-----LQNEGSSRHPSVSDEEENFAVLRRHVMNELLETERAYVEELLCVLEGYAAEMD 656

  Fly   452 GPLERHLNQDEL----RLIFPRIRELVDIHTK-FLDKLRESLTPNAKVKMAQVFLDFREPFLIYG 511
            .|...||..:.|    .::|..:.|:...|.| ||.:| |:.|...:: :.|.||:......||.
Zfish   657 NPAMSHLIPNTLLHKKDILFGNMSEIYQFHKKTFLREL-EAYTDYPEL-VGQCFLERMTDLQIYE 719

  Fly   512 EFC-------SLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLL 569
            ::|       ||.....|     |       ...|:|::... .||.|...|..|:|||.||.||
Zfish   720 KYCQNKPRSESLWRQCSD-----C-------AFFQECQKKLE-HKLGLDSYLLKPVQRITKYQLL 771

  Fly   570 LDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSD 634
            |.:|:|.:.....: ..|:.|..:::.:.:.:|    ||.||:.|...:           ||.||
Zfish   772 LKELLKYSKGCEGE-EDLQEALSSILGILKAVN----DSMHLIAITGYE-----------GNLSD 820

  Fly   635 LLQYGRLLLDGEL-----HIKAHEDQKTKLRY------AFVFDKILIMVKALHIKTGDMQYTYRD 688
            |   |||::.|..     |.|.|...|...|:      .|:.:|.|:..|             :.
Zfish   821 L---GRLMMQGSFSVWTEHKKGHAKVKDLARFKPMQRHLFLHEKALLFCK-------------KR 869

  Fly   689 SHNLADYRVEQSHSRRTIGRDTRFKYQLLLA-------RKSGKTAFTLYLKSEHE---------- 736
            ..|...|....|:|         ||:.|.::       .|.....|.::..|..|
Zfish   870 EENGEGYEKAPSYS---------FKHSLSMSAVGITENAKGDNKKFEIWCNSREEVYIVQASTPE 925

  Fly   737 -RDKW----RKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQI 796
             :..|    ||.||..:::......|.:..::...|  ..:|....|.|           |....
Zfish   926 IKTAWVNEIRKVLTRQLKACREASQQKSSDQISPLT--PSSTGLTLSPF-----------KTNPK 977

  Fly   797 SVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQG- 860
            |:.||....|.....:|.|......:.:|.:....:.|.:|...|.:           |...||
Zfish   978 SLKKGDEKKTEPTTTDPSSAALFKNNDKLKDETVVSPNTERAAVAKK-----------RFTLQGF 1031

  Fly   861 -----------PSTAHETMYALSLKTDDNVI------KHMKINQEN--SGDSMLYCLSSRRHFKT 906
                       ||..|:|    ..::|....      .|:.:.:..  |..|:|.  :.||.|..
Zfish  1032 SNLKSQKGSSPPSPDHKT----KRQSDPTPFGFRDAGPHITLTRVRWLSTSSLLQ--TKRRGFTK 1090

  Fly   907 IVELVSYYERNDLG------------ENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTD 959
            ....:...|.|| |            |:..|...|   |.|.|:..   |:: |:|..:|.:::.
Zfish  1091 ASLSMDASEEND-GYSSAEDPMNSDPEDEGGKKLS---PGKYVVVA---DHD-KSGPQELTVKSG 1147

  Fly   960 CQVLVIGKDGDSKGWW-RGKIGDTVGYFPK--------EYVQEQKLASEE 1000
            ..|.:: ::||...|: |.......|:.|.        |....|.|:|.|
Zfish  1148 DTVQLV-REGDDGRWFVRNLRTSKEGWVPAANLLTLIGESKSSQSLSSSE 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	0/1 (0%)
		RhoGEF	428..603	CDD:279015	50/190 (26%)
		PH_Vav	624..753	CDD:269930	34/161 (21%)
		PH	641..749	CDD:278594	27/140 (19%)
		C1_1	761..804	CDD:278556	8/42 (19%)
		SH2_Vav_family	824..934	CDD:198193	26/141 (18%)
		SH3	940..993	CDD:302595	12/61 (20%)
mcf2la	XP_021332781.1	SEC14	73..219	CDD:214706
		SPEC	386..552	CDD:321951	35/230 (15%)
		RhoGEF	626..803	CDD:238091	51/192 (27%)
		PH_Dbs	810..941	CDD:269934	35/166 (21%)
		SH3_DBS	1127..1181	CDD:212791	13/58 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910