DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and cit

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_031751702.1	Gene:	cit / 100145758	XenbaseID:	XB-GENE-981097	Length:	2078	Species:	Xenopus tropicalis

Alignment Length:	1009	Identity:	183/1009 - (18%)
Similarity:	329/1009 - (32%)	Gaps:	295/1009 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LVIHLDPSS--LDPREFNRKPQMAQFLCSK------NIKLFLDVCHNNFGIRDADLFEPTMLYDL 119
            |.:||..:.  .:.:..|.:.||.:.|..|      .||...::|..|..:.:.......:...:
Frog   755 LEVHLKQNEQVYEEKARNIETQMKKDLADKEALELSRIKNEEEICEKNRILSEQKAMINALESKI 819

  Fly   120 TNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMR-KTSSIDA 183
            |:..:   .|::||:..|        :..|..|.......:.|.:..:|......:. :...|:|
Frog   820 TSLEQ---RLAELSEANK--------LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKIEA 873

  Fly   184 SASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSD 248
            ......|..:|.:.....|:|..:.:|....:|              :::::.:...::..|...
Frog   874 QNQKLEEQLERINNQDHTDKNRLLELETRLREI--------------SLEHEEQKLELKRQLTEV 924

  Fly   249 CQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPL----AAAAPSVPVSAAPGPPM 309
            ......||...        |:...|.:|:    ||...|:::.|    |.|...:.|..:....:
Frog   925 QLTLQERETQI--------SSLQSARSAL----ESQLHQAKTELEDTTAEAEEEIQVLRSHRDEI 977

  Fly   310 GRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAK 374
            .|...|...|.::|.....:|.|.:       ...|...::..|:                  :|
Frog   978 QRKFDTLRDSCTVLTELEDQLNRIS-------QENADLNNQNFYL------------------SK 1017

  Fly   375 AKPEVT--TDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQR----DYVIRELI 433
            ...||:  ||.|....:..||...:..|....|.:..:|..:...:.|..|::    :.:..||:
Frog  1018 QLSEVSGATDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELL 1082

  Fly   434 DTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQ 498
            :.|..:        ..:...||....|.|.||     ||:    .:.||..::|     :|:..|
Frog  1083 EKERQW--------ESWRSSLEDEKTQFECRL-----REV----QRLLDTEKQS-----RVRSDQ 1125

  Fly   499 VFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQII-DQLVQKCERDYNVGKLQLRDILSVPMQR 562
            ...:.|:         .:.|.|.::.|::....|.: ||            ||:...:...| .|
Frog  1126 RTTESRQ---------MVELAAKEHKAEILALQQALKDQ------------KLKTESLSDKP-AR 1168

  Fly   563 ILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLL 627
            ||..   |:.|.|:.:.|..:.|||::..|...::.|.:.|.:......:.:||       .|:.
Frog  1169 ILNQ---LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK-------NHIF 1223

  Fly   628 QNGNG-------SDLLQYGRLLLDGELH----IKAHE--------DQKTKLRYAFVFDKILIMVK 673
            :...|       :|||:..|..|:.:|.    :.:||        .|:|||            :.
Frog  1224 RLTQGLQEALDRADLLKTERSDLEYQLENMQALFSHEKVKMEGTISQQTKL------------ID 1276

  Fly   674 ALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERD 738
            .|..|........:..:.|...|.::.:....:..... :.::.|.::..:||     :.|....
Frog  1277 FLQAKMDQPSKKKKVQNGLFSRRRDEPNQTSQVPLQYN-ELKVALEKEKARTA-----ELEEALQ 1335

  Fly   739 KWRKALTEAMESL-----------EPPG-----------CQSTDHKMEIYTFDAPTTCR------ 775
            |.|..|..|.|..           ..||           .:|.:|:....:..||...|
Frog  1336 KTRIELRSAREEAAHLKVSDHPVPSTPGTARQQIIMSALVRSPEHQPNAVSLLAPQNSRRKESSA 1400

  Fly   776 --HCSKFLKGRIH-------------QGYRCKVCQISVHKG-----CISSTGRCKQNPVSVPPPV 820
              ..|:.||.|:|             :..:|.||..:||.|     |:.....|.....|..|..
Frog  1401 PEEFSRRLKERMHHNIPHRFNVALTMRAAKCSVCLDTVHFGRQGAKCLECQVMCHPKCSSCLPAT 1465

  Fly   821 CDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIK---H 882
            |            .:..|.|:|..|      ...|.:...|        .:..|..:.|::   .
Frog  1466 C------------GLPAEYASHFTE------AFCREKMNSP--------GMQTKEANGVVRLEGW 1504

  Fly   883 MKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVI----ATALY 943
            |||.:.|                         :|...|           |..|.|:    ...:|
Frog  1505 MKIPRNN-------------------------KRGQQG-----------WDRKYVVLEGSKVLIY 1533

  Fly   944 DYEPKAG----SNQLQL-RTDCQVLVIGKDGDSK 972
            |.|.|.|    |.:.:| ..|..|.|.|..|.::
Frog  1534 DTELKEGGQRPSEEFELCLPDGDVTVHGAVGSTE 1567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	14/76 (18%)
		RhoGEF	428..603	CDD:279015	38/175 (22%)
		PH_Vav	624..753	CDD:269930	27/158 (17%)
		PH	641..749	CDD:278594	20/119 (17%)
		C1_1	761..804	CDD:278556	16/68 (24%)
		SH2_Vav_family	824..934	CDD:198193	15/112 (13%)
		SH3	940..993	CDD:302595	12/38 (32%)
cit	XP_031751702.1	STKc_CRIK	97..424	CDD:270752
		Smc	450..1179	CDD:224117	94/532 (18%)
		EnvC	1123..>1349	CDD:227278	53/275 (19%)
		CRIK	1414..1469	CDD:410364	11/66 (17%)
		PH	1499..1618	CDD:214574	21/105 (20%)
		CNH	1648..1944	CDD:413319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910