Protein Alignment Vav and arhgef7

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_012813343.1
• Gene: arhgef7 / 100145259
• XenbaseID: XB-GENE-962606
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 1044
• Identity: 196/1044 - (18%)
• Similarity: 346/1044 - (33%)
• Gaps: 324/1044 - (31%)

  Fly    23 ECVAWLTRCKVI-PPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLD-----PREFNRKP 81
            :.|.||....|: .|....:.|:.   .|..:|:|||:||.|:..|.|.|:|     ||....
 Frog     6 QTVTWLITLGVLESPKKTISDPEG---FLQTSLKDGVVLCRLLERLLPGSIDKVYPEPRTDTE-- 65

  Fly    82 QMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLI 146
                  |..||:.||..| :.|.:   :.|:...||...||::||.:|..|::.
 Frog    66 ------CLGNIREFLRGC-SAFNL---ETFDANDLYQGQNFNKVLNSLVLLNKV----------- 109

  Fly   147 GFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIEN 211
                                   :.|:.:...|....|:|...:.:|.......|..:|.: :::
 Frog   110 -----------------------TADIGLGSDSVCARSSSHRIKSFDSLGSQSVLSRSSKL-LQS 150

  Fly   212 GTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTT------ 270
            ....: |..|:|..:|......|              .|.::..||||:.. |::..|.
 Frog   151 QYRSL-DMTENSNHHMVVRAKFN--------------FQQTNEDELSFNKG-DLIHVTRLEEGGW 199

  Fly   271 -DGASNAVTP-TPESYARQSQSPLAAAAPSVPVSAA-PGPPMGRLVSTSSSSSSLLVSESQRLQR 332
             :|..:..|. .|.:|.|:.:|   :..|..|.|.. ..||.|  ..||:.:.|
 Frog   200 WEGTHSGKTGWFPSNYVREVKS---SEKPVSPKSTTLKSPPKG--FDTSAINKS----------- 248

  Fly   333 AAAAVYN-YRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNT 396
                .|| ...::..||.||:
 Frog   249 ----YYNVVLQNILDTEGEYS-------------------------------------------- 265

  Fly   397 KEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQD 461
                                             :||.|..||||               |||...
 Frog   266 ---------------------------------KELQDILSNYL---------------RHLQTS 282

  Fly   462 E------LRLIFPRIRELVDIHTKFLDKLRE-SLTPNAKVKMAQVFLDFREPF-LIYGEFCSLLL 518
            |      :..:...:.|:.......:..|.| :..|..:.::...|:...... .:|..:|:...
 Frog   283 EKLSPTNISYLLGNLEEICAFQQILVQSLEECTKLPEGQQRVGGCFMSLMPQMKSLYIAYCANHP 347

  Fly   519 GAIDYLADVCKKNQIIDQLVQKCERD--YNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLH 581
            .|::.|      .|..::|.:..|..  .:.|.|.|...||.|..|:.||..||.:|.:.....|
 Frog   348 SAVNVL------TQHSEELGEFMEMKGANSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYH 406

  Fly   582 DDYRSLERAKEAMIDVSQYINEV-KRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDG 645
            .|...::::..|..::|....|| ||....|.|:.:.         ::...|.|:...|.::...
 Frog   407 PDRPDIQKSMTAFKNLSAQCQEVRKRKELELQILTET---------IRGWEGEDIKTLGTVIYMS 462

  Fly   646 ELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADY---RVEQSHSRRTIG 707
            ::.|:....::...||..:|..:|:|:.|....:|   :.|:....|...   ::|.:.:.:.
 Frog   463 QVMIQCAGSEEKNERYLLLFPNVLLMLSASPRMSG---FIYQGKIPLTGMCVTKLEDNENHKN-- 522

  Fly   708 RDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYT-FDAP 771
                 .|::     :|.....:.:...:::|     |.|.::.|         ||...|| ...|
 Frog   523 -----AYEI-----AGNMIERIIVSCNNQQD-----LQEWVDYL---------HKQTKYTSLINP 563

  Fly   772 TTCRH---CSKFLKGRIHQGYR---CKVCQIS---------VHKGCISST-GRCKQNPVSVPPP- 819
            |...|   |.......:....:   ||:..::         .|.|...|| ......|...|.|
 Frog   564 TIKPHSVPCHTLPSHPVTPSSKHSDCKLMPLTPAYHTLPHLSHHGTPHSTISWSPLEPPKTPKPW 628

  Fly   820 --VCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYAL-----SLKTDD 877
              .|.|........|....:|..:.  ..:.:...|.:.:|:...:..|  :||     :|:.|.
 Frog   629 SLSCLRPAPPLRPSAALCYKEDLSK--SPKTMKKLLPKRKPERKPSDEE--FALRKSTAALEEDA 689

  Fly   878 NVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATAL 942
            .::|.::          .||.|:    ||...|.|.::..||..|             .|:|.
 Frog   690 QILKVIE----------AYCTSA----KTRQTLNSTWQGTDLMHN-------------HVLAD-- 725

  Fly   943 YDYEPKAGSNQLQLRTDCQVLV---IGKDGDSKGWWRG---KIGDT----VGYFPKEYV-QEQKL 996
               :.::..:.|..|:....|.   :.:|.|....|..   ::|.|    .|..|:..: :|:|:
 Frog   726 ---DDQSSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRCRKGSTPQVLLPEEEKI 787

  Fly   997 ASEE 1000
            ..||
 Frog   788 IVEE 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	35/114 (31%)
		RhoGEF	428..603	CDD:279015	39/184 (21%)
		PH_Vav	624..753	CDD:269930	20/131 (15%)
		PH	641..749	CDD:278594	16/110 (15%)
		C1_1	761..804	CDD:278556	12/58 (21%)
		SH2_Vav_family	824..934	CDD:198193	20/114 (18%)
		SH3	940..993	CDD:302595	10/63 (16%)
arhgef7	XP_012813343.1	CH	21..100	CDD:237981	27/93 (29%)
		RhoGEF67_u1	116..162	CDD:293221	8/47 (17%)
		SH3_betaPIX	166..219	CDD:212994	13/67 (19%)
		RhoGEF	250..427	CDD:238091	45/274 (16%)
		PH_Cool_Pix	458..556	CDD:269932	19/126 (15%)
		PH	476..556	CDD:278594	18/108 (17%)
		RhoGEF67_u2	615..710	CDD:293220	21/112 (19%)
		betaPIX_CC	772..858	CDD:293131	6/20 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910