Protein Alignment rictor and rictora

DIOPT Version :9

• Sequence 1: NP_573371.1
• Gene: rictor / 32919
• FlyBaseID: FBgn0031006
• Length: 1936
• Species: Drosophila melanogaster
• Sequence 2: XP_021332070.1
• Gene: rictora / 561703
• ZFINID: ZDB-GENE-060526-49
• Length: 1703
• Species: Danio rerio
• Alignment Length: 1860
• Identity: 527/1860 - (28%)
• Similarity: 825/1860 - (44%)
• Gaps: 389/1860 - (20%)

  Fly    13 RSKLQLRIKVSQDP-EDFYRLDPQRSAAENAFEIYSMLCLEE-TRDTKRLFLLNALASLCLGARK 75
            |....:|::...|. |:...||..|..::|..||...:.... ..:.::|..||....|   ...
Zfish     8 RPTRSVRMRGRNDSGEENVPLDLTREPSDNMREILQNIAKSHGVSNMRKLGHLNNFVKL---LNS 69

  Fly    76 GSH-HSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSID 139
            .|| ...:.||.||::.||..:|::...:||||.||.:||.|...:.::....||:.:|:.|.||
Zfish    70 VSHCEEKLGFTHEEIIICLRVALLNEVKEVRAAGLRALRYLIRDSSILQKVLQLQVDYLISRCID 134

  Fly   140 LMLKNDDERVQALKLVRKMLAIAPEDISPAVVRCLVSLADSGIEENDNLLRACLATLAEFAVLNP 204
            :...|:.||.|||:|||||:.:..:....:|...|:::...|::|.|.::|||:|.:.|.|:.||
Zfish   135 IQQSNEVERTQALRLVRKMITVNAQLFPSSVTNSLIAVGSDGLQERDRMVRACIAIICELALKNP 199

  Fly   205 ALLIVCGGVTSITRNVLECHNPRIAESLCGVLLYLLEWPQTRNI--CGVRLDCLAAPYCDFTYR- 266
            .::...||:::|.:||::|...||.|:|...:|:||..|.||..  ..|.|:.:.|||.||.||
Zfish   200 EVVAQRGGLSTILKNVIDCQLSRINEALITTILHLLNHPHTRQFIRADVELEQILAPYTDFHYRH 264

  Fly   267 --QSIVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVDALYLNQIEVRKAIL 329
              ::...:.|:.||.|:.:.::|:::..|||:|.:..| .|..||:::::..|.:..::||||:|
Zfish   265 NPETAEAQIKEDREARFLASKMAIVAAFRSWSGIINLC-KSGNSGVQSLIGLLCIPNMDVRKALL 328

  Fly   330 DLLYELLTLPQPTWTDDYAVALQAVDPSDFQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLA 394
            ::|||:..||.|..|.|:..||.:||||.|||:|.||:|||:||.:.|||..|...|.:::.:||
Zfish   329 EVLYEIFRLPVPLVTGDFEEALHSVDPSRFQDSWRLSDGFVAAEAKVILPHRARSRPDLMDNYLA 393

  Fly   395 LMLYCFLETGLLNALVEVVVSSDQFVSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHAT- 458
            |:|..|:.:|||..|||||.|||..:||:||:|:|::|.:.:|.||.........||||::.|.
Zfish   394 LLLSAFINSGLLEGLVEVVTSSDGQISVRATILLGELLHMANTILPHSHSHHLHCLPTLINMAAS 458

  Fly   459 --LGNQ---QANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQTRLFRRHLNVQEQAGPVL 518
              :..:   :|:|||..|:.:.:..|:.|...||:|..|
Zfish   459 FDISQEKRLRASAAVNHLKRFHEKKRRGPKPYSLYLHHI-------------------------- 497

  Fly   519 QLQETAEAAAFAVPPVTQFRGTLDRSRLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFR 583
             |..|:                         |||...:.|.....:..:.:|         |...
Zfish   498 -LHRTS-------------------------SSSHRRDQQHHRPHKDIYIMK---------DTEE 527

  Fly   584 AFNRLLTDSRVLSQADAHLWDWDVITTILK---SNLIRKLDYTQGKFLKRLVDFYKPRNNRFSHQ 645
            |....|.||::|:......|:|.:|.||||   .||....|....||::||:.||||.:..:|..
Zfish   528 ALMMNLRDSQILNHKQNLDWNWILIITILKWPNVNLKNIKDEQMHKFVRRLLYFYKPSSKLYSAL 592

  Fly   646 DLVPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQQLAAVTTSNRAHDCLFSPQ--- 707
            :|...:.....| ||......||.|.| :...::.:...||.|.|    ||:..    ..|:
Zfish   593 ELDHAKARQLTV-AGCQFNQFLLDSEE-DGQSYLEELVKDIVQWL----TSSSG----LKPERSL 647

  Fly   708 HMN---NTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINL--VRVTDHVCYVKLIVSGLNYSY 767
            |.|   .|:.|.|||::|.:.....|:::|:...||:.|:||  ::..||:  :||.||.|:||.
Zfish   648 HSNGLLTTLNQHYFLFLGTLSAQPHGVKMLEKCGVFQCLLNLCSMKNQDHL--LKLTVSTLDYSR 710

  Fly   768 EKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVL 832
            :.|.|.:|.|.||:|....|||:|:.:.|||||.:..|..||:.|::.|..|.::::.:.|:|:|
Zfish   711 DGLARVILSKILTAATDNCRLYATKHLRVLLRANVEFFSNWGMELLVTQLHDHNKTISMEALDIL 775

  Fly   833 EEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRY 895
            :|||.||..|..::...|.|:|.||.|.||:.|:.|:|:|.:....|  :..::..|...||.:|
Zfish   776 DEACEDKANLHALIHMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVSKQLEKWLKEYNLKY 840

  Fly   896 VLLVEADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNV--APHLYGQMAQTGQGMTALRKHGDL 958
            |.::|...:.:||.:.:..||....|..|||.|.  |||  ..|||||:.....|...|...|.:
Zfish   841 VDMIEEQLNEALTTYRKPVDGDNYVRRSNQRLQR--PNVFLPVHLYGQLVHDKTGCLLLEAQGVI 903

  Fly   959 PQLLELLRRAKCTDDAECLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVR 1023
            |.|...:|...........:||||:|||.:..:.:.|:...:|.|  :...:|.|...|||.|:|
Zfish   904 PDLSYTVRSPVLDKWEGVKQLKAALWALGNIGSSNWGLNLLLEEN--VIPDIIALAQHCEVLSIR 966

  Fly  1024 ATCFSALGLIAGTQAGANILFKLNWLSVRHDKNTMWPVHQPED----------------WMSSQY 1072
            .||...||:|:.|:.|:::|....|.||||.:...||| .|::                .::|:.
Zfish   967 GTCVYVLGVISRTRQGSDVLKASGWDSVRHSRRQQWPV-VPDEVEVPLPSELSSVPSTLSLNSES 1030

  Fly  1073 TPVRHYYEDVPADNMTMMDDYIE--RFYETGSDFWHMLADQ------------------------ 1111
            |..||..|.....::..|||..|  ..||..|...|....:
Zfish  1031 TSSRHNSESESQPSLYFMDDDREGLDIYEDSSLSMHAKTSKERSPFTILTPSHLRNRFLNSLSLP 1095

  Fly  1112 -------TDASGGG------------------GGVAGTVVGMHPIV-------QDPNATITTTDS 1144
                   ||..|..                  ..||.:..|...:.       :.|..::.|:
Zfish  1096 SKKGRSPTDTKGTSFTAKTPDELRLMHCNRSIAEVANSSPGHSEVFYNGSRMPRSPTVSLETS-- 1158

  Fly  1145 VRTTTDDVHPRMLVGVAAKSKTLPEGSNLR-QGKHQRSLSESKTTDVISLLGSGVGTMSGAVLYP 1208
                        .||:.|.::.....|..| |.|.:|:..|..|.|..|:|..| ||
Zfish  1159 ------------FVGIKALAEPYATDSESRNQFKRERNSRERLTCDGASVLPGG-GT-------- 1202

  Fly  1209 TPYQHRIR-YNSCTDSNTSGVSSCESVTGRTAA---------AYAAAANELQQFPLSP----IPS 1259
              ::.|.: :|  ||:.|||:||..|...|..|         ...:|.....|..|||    :.|
Zfish  1203 --FKSRSQSFN--TDTTTSGISSMSSSPSREPAMDTDCASLNTVVSARTVKMQHSLSPNNHILLS 1263

  Fly  1260 MSNLL------ESDELFRRNQLATSMLPSTL-----------SPMAMKGYVQLRSLRKHS-RPVF 1306
            .||..      .:..|.||.|...|...:|:           ||....||..|:.|::.. .|..
Zfish  1264 KSNSTSLVPPGSAHTLPRRAQSLKSPSVATIKSLVDCSYMYTSPRDALGYATLKRLQQQRIHPSL 1328

  Fly  1307 SESSAEFYDFAEILDTPEVQMRKLDWTHSHRRLKVRSLDRQLSDVYRRLSADELNVLLPTLNAPK 1371
            |.|.|......::|.|..:.|            |.||||.:|:.  ||
Zfish  1329 SHSEALASPAKDVLFTDTITM------------KTRSLDSRLTP--RR----------------- 1362

  Fly  1372 FLPPNDLKGPCYAGICLPKNVLDLF-PTRNLSRTYV----------SRDIQD------------- 1412
                           |.||.....| .:|.||||:|          |.|.:|
Zfish  1363 ---------------CSPKRYFGPFSSSRRLSRTFVPWFLKALSFASLDKEDLLSPINHSTLQRS 1412

  Fly  1413 ---------------QDIVGINL---LNTMLR---PQCLNDSLTNEGGDESSVIS---------- 1446
                           :|.:|:.|   :|.|.:   ........:...||:||..:
Zfish  1413 SSLRSMVSSATFGCSEDYIGLALPLDINNMFQIKETSYFQKRTSPPAGDKSSKFNFGESDGFLES 1477

  Fly  1447 ----------SLSDVSSASRRQTRQLQQGA-------KHSRSLCLHCA------RSPRQQRNDSG 1488
                      |::::.::||.:...| .||       :|:...||:|:      .......|::.
Zfish  1478 CRGPPLKQQVSITELLNSSRSEQHHL-LGAEETTGLQEHTEQNCLYCSAINALGSHTHSHLNNTH 1541

  Fly  1489 SHSNGGGGASLAPCELYSSAAAALVAAGIQAGPVLAKKSG-SSAQGASAALGADISFHSPESML- 1551
            :|::...|.|    :.:|..:...:....|     :|.|| |....|:.:.|:..|..|.|.:|
Zfish  1542 NHNDLSDGFS----QWHSQPSHNHLEVVTQ-----SKFSGVSGCSDAAVSQGSACSTPSTEIILG 1597

  Fly  1552 ----SEDSLPDR--LTASILYNVQRLANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGR 1610
                |||....|  |...:|..|..|::.|..|..:..||.:|:|.|:||.|||||||....:..
Zfish  1598 GKAISEDGPACRVLLRKEVLRLVINLSSSVGTKGHETGLLTIKEKFPYAFDDICLYSEVSFLLAS 1662

  Fly  1611 SSYRMIARRFLQELFLDLNFDSFYVEPQLIIGARKFSAEE 1650
            .::|:.:|||:||||.|:.|...|.|.:.::  .|.|.|:
Zfish  1663 CTFRLASRRFIQELFQDVQFIPLYDEAEAVL--TKPSVED 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rictor	NP_573371.1	RICTOR_N	63..440	CDD:291336	149/382 (39%)
		RICTOR_M	583..798	CDD:291338	75/225 (33%)
		RasGEF_N_2	805..908	CDD:291335	34/104 (33%)
		RICTOR_V	977..1047	CDD:291340	25/69 (36%)
rictora	XP_021332070.1	RICTOR_N	60..437	CDD:317109	148/380 (39%)
		RICTOR_M	652..741	CDD:317111	34/90 (38%)
		RasGEF_N_2	748..854	CDD:317108	35/105 (33%)
		RICTOR_V	923..990	CDD:317113	25/68 (37%)
		RICTOR_phospho	1075..1184	CDD:317110	15/122 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595165
Domainoid	1	1.000	282	1.000	Domainoid score	I1618
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I856
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D128601at2759
OrthoFinder	1	1.000	-	-		FOG0005060
OrthoInspector	1	1.000	-	-		otm24532
orthoMCL	1	0.900	-	-		OOG6_103652
Panther	1	1.100	-	-	O	PTHR13298
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4097
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900