DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rictor and rict-1

DIOPT Version :9

Sequence 1:	NP_573371.1	Gene:	rictor / 32919	FlyBaseID:	FBgn0031006	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	NP_001254377.1	Gene:	rict-1 / 3565035	WormBaseID:	WBGene00009245	Length:	1580	Species:	Caenorhabditis elegans

Alignment Length:	1747	Identity:	374/1747 - (21%)
Similarity:	619/1747 - (35%)	Gaps:	492/1747 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CLSASLVHTFTQVRAAAL--RTIRYAISTPNDIKTFNALQLQHLLCRSIDLMLKNDDERVQALKL 154
            |:.|...|   .||...:  |.:...::|..||          .:.|:|||.::|..||::|.||
Worm   111 CIRAMCFH---MVRKCTINERNLVVILTTHVDI----------FIVRAIDLQMENQTERLEAFKL 162

  Fly   155 VRKMLAIAPE-------DISPA------------VVRCLVSLADSGIE-----ENDNLLRACLAT 195
            :..||.|..:       |.|.|            :::.::|:|.|..|     ..|.|...|:..
Worm   163 IIWMLKIYEKSNLKKLIDSSAAQKNGKKYAFPKSIMQPIISIALSAFEGQQTTGKDKLTLPCVGL 227

  Fly   196 LAEFAVLNPALLIVCGGVTSITRNV--LECHNPRIAESLCGVLLYLLEWPQTRNICGVRLDC--- 255
            ..||::..|.|::...|...:.:.:  :.|.:.||......||:..|:.|..|  ....||.
Worm   228 FLEFSLTEPLLVLEMAGTDWLVKALTGVSCMSRRIVLLASHVLISWLDSPTIR--IKAHLDLVME 290

  Fly   256 -LAAPYCD---FTYRQSIVDKNKDARELRY------TSCRLALLSVLRSWTGTLEFC---DPS-- 305
             :.||..:   |..|.|::..:...|...:      .:.:.:.|.::|||.| |..|   .|:
Worm   291 QIFAPLVEFGLFQKRGSMLTNDNALRNEAFHMNDFLENFKCSFLRIIRSWPG-LFACAAVGPNSN 354

  Fly   306 -KPSGLKAIVDALYL------NQIEVRKAILDLLYELLTLPQPTWT-DDYAVALQAVD----PSD 358
             :||....::|.|.|      |.:.:|..|:||..|.:.:|....| :.:..||....    |..
Worm   355 IRPSSPFRLLDYLGLGTVANDNLVRIRDTIVDLCCEFVDVPYANKTFESWEEALSFYKTMHLPDK 419

  Fly   359 FQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLA---LMLYCFLETGLLNALVEVVVS-SDQF 419
            |:..  |.|.||.|:..:.|.....|....::...|   |..:..:...|..:|..:::: .|..
Worm   420 FKSN--LKNDFVIAQNDARLKNDTERRKPTIDLLAAFRVLSQFVLINAQLPLSLARLILAMPDSS 482

  Fly   420 VSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHATLGNQQANAAVA--------------- 469
            ..::||:|:..:|:...:|:|........::||||..|.....|::|..|
Worm   483 SGLKATLLMADMLRQAPSHVPMGYRAPVLSMPTLVQSACESLSQSHAVAAINGTFDINTTEQYTF 547

  Fly   470 --------ALQNYQKLLRQ--RPASRS----------LF------------------LDSIIQGG 496
                    .|..:.||.:.  |.||.|          ||                  .||..:.|
Worm   548 LHATNAELVLNRFDKLNQSWIRSASTSSTVLKESDLMLFSPHMSEPIPLASTMKKSKSDSSFRSG 612

  Fly   497 ALIQTRLFRRHL--NVQEQAGP---------------VLQLQETAEAAAFAVPPVTQFRGTLDRS 544
            .    ..|:|:.  :|.|:..|               .|.|.:.|:...:|.|.:   |.|||
Worm   613 G----SFFKRNTSPDVYEEESPGEFSETVLRGRYDKNALMLMDDADDYDYAAPNI---RDTLD-- 668

  Fly   545 RLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFRAFNRLLTDSRVLSQADAHLWDWDVIT 609
                   .:|.|:             :||    ..|:..||                  ||:.:.
Worm   669 -------DEEENA-------------KKF----FVDSTGAF------------------DWNYVE 691

  Fly   610 TILKSNLIRKLDYTQGKFLK------------RLVDFYKPRNNRFSHQDLVPGQRLPTYVSAGLD 662
            ..:::  |.|..|.  |.||            .:..:..| :.:..|:..:..|:    |.....
Worm   692 YYVEN--IEKDGYE--KLLKEFTSNTIQVHISNMFQYISP-SEQEKHKRCIDRQQ----VIVTKS 747

  Fly   663 LIDVLLSSNELECMRFITDYFSDI----SQQLAAVTTSNRAHDCLFSPQHMNNTMCQQYFLYIGR 723
            ||.:||...:.|.  .|:|.:..|    .:...|:.......:..|:.::::.|....:|..||.
Worm   748 LIKLLLRVFQKEA--HISDAYQPIFLKYVESFKALLEKRSNPNAYFAARNLSYTNSMLHFAIIGT 810

  Fly   724 MCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRL 788
            ...|.||:.:|.|..|....::::..|..:.|.|:|:|.|:|:.|.:.|.::.|||||.....|.
Worm   811 FTMTSKGLSILTNAGVLHMYVDILSSTSQLEYTKVIISSLDYTNEGMVRVIIGKALTSTSEASRK 875

  Fly   789 YSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSR----- 848
            ::|:::|||....||.|..|||..::.|..|....|....:.:|..      :|.|..||
Worm   876 WTTRYLAVLASFDLPTFSDWGIQYMLRQLADESSKVVRHTIRILNR------WLPEHPSRNLRKI 934

  Fly   849 -WPNLTHRGDAGRLLMARYYSLPRGLNSTMARIEDEIRYWRNGYNKRYVLLVEADTHSSLTLHI- 911
             |...   |:||.||.|..:::.....|....:.|.:|:|.:.:||:|:.:::.:. ..:..|:
Worm   935 DWSLF---GEAGDLLRAHVFAMESECASDEDEVRDVVRFWMSDFNKKYLNIIDEEM-KEMMFHVK 995

  Fly   912 RNEDGYYSRRNCNQRPQTVPPNVAP-HLYGQMAQTGQGMTALRKHGDLPQLLELLRRAKCTDDAE 975
            |:.||.:| |:.:..|.|.....|| ||:..:.....|...|........||.:.:..||.:
Worm   996 RSIDGSFS-RSSSDIPDTSLGVQAPLHLFAALGSHETGRHILIDENVAEDLLSICKTGKCFE--- 1056

  Fly   976 CLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVRATCFSALGLIAGTQAGA 1040
              |:||::.|::...:...|.|.   |.|.....:|.:..:..|.:||...|.||...:....||
Worm  1057 --EIKASLLAVSSIGSTDGGFEI---LPADAVPVVIKIAEEHPVLTVRGIAFWALCTFSQCIEGA 1116

  Fly  1041 NILFKLNWLSVRHDKNTMWPVHQPEDWMSSQYTPVRHYYEDVPADNMTMMDDYIERFYETGSDFW 1105
            ..|....|.|.|.                       .|..|:....
Worm  1117 KRLGSFGWESNRF-----------------------RYAMDLAKSK------------------- 1139

  Fly  1106 HMLADQTDASGGGGGVAGTVVGMHPIVQDPNATITTTDSVRTTTDDVHPRMLV----GVAAKSKT 1166
             ::||  |..|..||..            |.:|.::....|..|...|....:    ....:|:.
Worm  1140 -VVAD--DEPGTPGGAT------------PGSTCSSWRPARKITIQSHRNSSMVDSQNNVKQSRA 1189

  Fly  1167 LPEGSNLRQGKHQRSLSESKTT----DVISLLGSGVGTM-------SGAVLYPT---------PY 1211
            ..|.:.:|:| |.:..|.|::|    :||:...|.:.:.       |...||.|         ||
Worm  1190 KSESALVRRG-HSKGRSRSQSTGDIHEVIAKRESRIDSFFNQRLWNSEKYLYKTSGTSDSSSIPY 1253

  Fly  1212 QHRIRYNSCTDSNTSGVSSCESVTGRTAAAYAAAANELQQFPLSPIPSMSNLLESDELFRRNQLA 1276
            ..|...||     :||....:..|..|               :|| |:..|:.|:        :.
Worm  1254 HKRTVTNS-----SSGYHIQDDTTAVT---------------ISP-PNHLNMEEN--------VC 1289

  Fly  1277 TSMLPSTLSPMAMKGYVQLRSLRKHSRPVFSESSAEFYDFAEILDTPEVQMRKLDWTHSHRRLKV 1341
            .|...|.:|..        |.....:..:|.|..|.                           |.
Worm  1290 KSAATSRISTD--------RRRANTTNSLFDEEEAP---------------------------KT 1319

  Fly  1342 RSLDRQLSDVYRRLSADELNVLLPTLNAPKFLPPN--DLKGPC-------------YAGICLPKN 1391
            |      |....|...|.|.:....|.|...|...  :|...|             .|.:.:.::
Worm  1320 R------SSTVARCIRDGLKITTEQLEAEGVLADGIMELHFSCRLREKYHLTAFRVRACLQITRH 1378

  Fly  1392 VLD----LFPTRNLSRTYVSRDIQDQDIVGINLLNTMLRPQCLNDS-LTNEGGDESSVISSLSDV 1451
            |.|    :|.||...|.:..                 .|.|.|.|. |.||...|.:.:....:|
Worm  1379 VGDPVRYVFMTREEERHFAD-----------------YRRQVLRDPWLYNELKKEDNTVKKTINV 1426

  Fly  1452 SSASRRQTRQLQQGAKHSRSLCLHCAR-SPRQQRNDS--GSHSNGGGGASLAPCELYSSAAAALV 1513
            ...   ||..|      ...:.:.|.. .|.:.::|.  ..|.|              ..:|.:.
Worm  1427 VPI---QTVAL------PTEIEIMCGNIFPAKPKSDPIFSFHEN--------------DDSAGVE 1468

  Fly  1514 AAGIQAGPVLAKKSGSSAQGASAALGADISFHSPESMLSEDSL-----PD--RLTASILYNVQRL 1571
            ..|.:.|..   :||...|..||..    .||...   :|||:     ||  .|...:|.:|..|
Worm  1469 DRGARTGHA---RSGIHIQPHSAYR----CFHCSS---NEDSVRIYPHPDAPMLRKEVLGHVDML 1523

  Fly  1572 -ANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGRSSYRMIARRFLQELFLD 1627
             .....||:    |:.|:|.||..|:..|:|::..:.:....::..:|.|||::|.|
Worm  1524 EIKEYPAKR----LIGLRQHHPWLFEWPCMYADVLELLDEYRFKPHSRAFLQQIFYD 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rictor	NP_573371.1	RICTOR_N	63..440	CDD:291336	95/409 (23%)
		RICTOR_M	583..798	CDD:291338	52/230 (23%)
		RasGEF_N_2	805..908	CDD:291335	26/108 (24%)
		RICTOR_V	977..1047	CDD:291340	18/69 (26%)
rict-1	NP_001254377.1	RICTOR_N	94..501	CDD:373204	94/407 (23%)
		RICTOR_M	785..885	CDD:373206	29/99 (29%)
		RasGEF_N_2	892..993	CDD:373203	26/110 (24%)
		RICTOR_V	1057..1123	CDD:373207	18/68 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166697
Domainoid	1	1.000	62	1.000	Domainoid score	I6859
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I2221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005060
OrthoInspector	1	1.000	-	-		oto17352
orthoMCL	1	0.900	-	-		OOG6_103652
Panther	1	1.100	-	-	LDO	PTHR13298
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1404
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010