DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rictor and Rictor

DIOPT Version :9

Sequence 1:	NP_573371.1	Gene:	rictor / 32919	FlyBaseID:	FBgn0031006	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	XP_038959455.1	Gene:	Rictor / 310131	RGDID:	1307224	Length:	1733	Species:	Rattus norvegicus

Alignment Length:	1843	Identity:	517/1843 - (28%)
Similarity:	835/1843 - (45%)	Gaps:	318/1843 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RSKLQLRIKVSQDP-EDFYRLDPQRSAAENAFEIYSMLC-LEETRDTKRLFLLNALASLCLGARK 75
            ||...|||:...|. |:...||..|..::|..||...:. |:...:.::|..||....|....
  Rat     8 RSLKNLRIRGRNDSGEENVPLDLTREPSDNLREILQNVAKLQGVSNMRKLGHLNNFTKLLCDI-- 70

  Fly    76 GSHHSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 140
            |.....:.|..|:::.||..:|::...:||||.||.:||.|...:.::....|::.:|:.|.||:
  Rat    71 GHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI 135

  Fly   141 MLKNDDERVQALKLVRKMLAIAPEDISPAVVRCLVSLADSGIEENDNLLRACLATLAEFAVLNPA 205
            ...|:.||.|||:|||||:.:.......:|...|:::.:.|::|.|.::|||:|.:.|.|:.||.
  Rat   136 QQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQERDRMVRACIAIICELALQNPE 200

  Fly   206 LLIVCGGVTSITRNVLECHNPRIAESLCGVLLYLLEWPQTRNI--CGVRLDCLAAPYCDFTYRQS 268
            ::.:.||:.:|.:||::|...||.|:|...:|:||..|:||..  ..|.|:.:.|||.||.||.|
  Rat   201 VVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS 265

  Fly   269 ---IVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVDALYLNQIEVRKAILD 330
               ...:.|:.||.|:.:.::.:::..|||.|.:..|.|.. ||:::::..|.:..:|:|:.:|:
  Rat   266 PDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGN-SGIQSLIGVLCIPNMEIRRGLLE 329

  Fly   331 LLYELLTLPQPTWTDDYAVALQAVDPSDFQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLAL 395
            :||::..||.|..||::..||.:|||..|||:|.||:|||:||.::|||..|...|.:::.:|||
  Rat   330 VLYDIFRLPLPVVTDEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLAL 394

  Fly   396 MLYCFLETGLLNALVEVVVSSDQFVSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHATL- 459
            :|..|:..|||..||||:.:||..:||:||:|:|::|.:.:|.||.........||||::.|..
  Rat   395 ILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASF 459

  Fly   460 -----GNQQANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQTRLFR-RHLNVQEQAGPVL 518
                 ...:|:||:..|:.:.::.::.|...||.||.|||  ..|.|...| ::|.||:.   :.
  Rat   460 DIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQ--KAIATHQKRDQYLRVQKD---IF 519

  Fly   519 QLQETAEAAAFAVPPVTQFRGTLDRSRLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFR 583
            .|::|.|                                                   ||..|.|
  Rat   520 VLKDTEE---------------------------------------------------ALLINLR 533

  Fly   584 AFNRLLTDSRVLSQADAHLWDWDVITTILK---SNLIRKLDYTQGKFLKRLVDFYKPRNNRFSHQ 645
                   ||:||...:...|:|::|.||||   .||....|....:|::||:.||||.:..::..
  Rat   534 -------DSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYASL 591

  Fly   646 DL--VPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQQLAAVTTSNRAHDCLFSPQH 708
            ||  ...::|..   .|....:.||.|.| :...::.|...||.|.|.|  :|....:.......
  Rat   592 DLDFAKSKQLTV---VGCQFTEFLLESEE-DGQGYLEDLVKDIVQWLNA--SSGMKPERSLQNNG 650

  Fly   709 MNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINL--VRVTDHVCYVKLIVSGLNYSYEKLP 771
            :..|:.|.|||:||.:.....|:::|:..:||:.|:||  ::..||:  :||.||.|:||.:.|.
  Rat   651 LLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHL--LKLTVSSLDYSRDGLA 713

  Fly   772 RQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEAC 836
            |.:|.|.||:|....|||:|:.:.|||||.:..|..|||.|::.|..|.::::...|:|:|:|||
  Rat   714 RVILSKVLTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEAC 778

  Fly   837 HDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRYVLLV 899
            .||..|..::...|.|:|.||.|.||:.|:.|:|:|.:....|  :..::..|...||.:||.|:
  Rat   779 EDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKYVDLI 843

  Fly   900 EADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNVAPHLYGQMAQTGQGMTALRKHGDLPQLLEL 964
            |...:.:||.:.:..||....|..|||.|.....:..|||||:.....|...|.....:.:|.:.
  Rat   844 EEQLNEALTTYRKPIDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQSIITELCQN 908

  Fly   965 LRRAKCTDDAECLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVRATCFSA 1029
            :|........|..:|||::|||.:..:.:.|:....|.|  :...::.|..:|||.|:|.||...
  Rat   909 VRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEEN--VIPDILKLAKQCEVLSIRGTCVYV 971

  Fly  1030 LGLIAGTQAGANILFKLNWLSVRHDKNTMWPVHQPED---------------WMSSQYTPVRHYY 1079
            |||||.|:.|.:||...:|.||||.:..:||| .|:|               .::|:.|..||..
  Rat   972 LGLIAKTKQGCDILKCHSWDSVRHSRKHLWPV-VPDDVEQLCNELSSVPSTLSLNSESTSSRHNS 1035

  Fly  1080 EDVPA-DNMTMMDDYIERF--YETGSDFWHMLADQTDASGGGGG----------------VAGTV 1125
            |...| .:|.:::|  :||  ..|.:.|..:..|...|.....|                |...:
  Rat  1036 ESESAPSSMFILED--DRFGSSSTSTFFLDINEDAEPAFYDRPGPIKDKNSFPFFASSKLVKNRI 1098

  Fly  1126 VG-------MHPIVQDP------NATITTTDSVRTTT----DDVHPRMLVGVAAKSKTL------ 1167
            :.       .|....||      :...|:...:||.|    |..|......::...|||
  Rat  1099 LNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTFTEPSVDFNHSDDFTNISPAQKTLQLETSF 1163

  Fly  1168 ---------------------------PEGSNLRQ-------------GKHQRSLSESKTTDVIS 1192
                                       ||  |.|:             |.|.:..|:|..||..:
  Rat  1164 VGNKHLEDTGSTPSIGDNDLKFPKSFGPE--NHRENTSRERLVVESSAGSHMKIRSQSFNTDTTT 1226

  Fly  1193 LLGSGVGTMSGAVLYPTPYQHRIRYNSCT-DSNTSGVSSCESV-TGRTAAAYAAAANEL-----Q 1250
               ||:.:||.     :|.:..:..:|.| |::...:|:..|. |.:|:......||.|     .
  Rat  1227 ---SGISSMSS-----SPSRETVAVDSTTMDTDCGSLSTVVSTKTVKTSHYLTPQANHLSLSKSN 1283

  Fly  1251 QFPLSP------IPSMSNLLESDELFRRNQLATSMLPSTLSPMAMKGYVQLRSL-RKHSRPVFSE 1308
            ...|.|      :|..:..|::..:.....||......|.|..|. ||..|:.| ::...|..|.
  Rat  1284 SVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAF-GYATLKRLQQQRMHPSLSH 1347

  Fly  1309 SSAEFYDFAEILDTPEVQMR-----------KLDWTHSH-------------------RRLKVRS 1343
            |.|......::|.|..:.|:           ::|:...|                   :.|...|
  Rat  1348 SEALASPAKDVLFTDTITMKANSFESRLTPSRIDFKKKHVGGIRSLRPTIANNLFRFMKALSYAS 1412

  Fly  1344 LDRQLSDVYRRLSADELNVLLPTLNAPKFLPPNDLKG-PCYAGICLPKNVLDLFPTRNLSRTYVS 1407
            ||::  |:   ||....|.|..:.:....:......| ..|.|:.||.::.|:|..:::. .:.|
  Rat  1413 LDKE--DL---LSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIP-YFQS 1471

  Fly  1408 RDIQDQDIVGI-------------------NLLNTMLRPQCLNDSLTNEGGDESSVISSLSDVSS 1453
            :.:...|..|.                   |..:.:.:...|.:.:.:...|.|..:.|..|..
  Rat  1472 KHVPPPDDRGARTFSHDGGGLPSGTGSLVKNSFHLLRQQMSLTEIMNSVHSDASLFLESTEDTG- 1535

  Fly  1454 ASRRQTRQLQQGAKHSRSLCLHC------ARSPRQQRNDSGSHSNGGGGASLAPCELYSSAAAAL 1512
                    ||:   |:...||:|      ...|..|.:...|||:    ....|   ||......
  Rat  1536 --------LQE---HTDDNCLYCVCIEILGFQPSNQLSSICSHSD----LQDIP---YSDWCEQP 1582

  Fly  1513 VAAGIQAGPVLAKKSGSS--AQGASAALGADISFHSPESMLSEDSLPD-------RLTASILYNV 1568
            :...::..|  :|.||.|  :.|||...|:..|..|.|.:|...::||       .|...:|..|
  Rat  1583 IHNPLEVVP--SKFSGISGCSDGASQEEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLV 1645

  Fly  1569 QRLANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGRSSYRMIARRFLQELFLDLNFDSF 1633
            ..|::.||.|..:..||.:|:|:|..|.|||||||....:...::|:..|||:||||.|:.|...
  Rat  1646 VNLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQM 1710

  Fly  1634 YVEPQ--LIIGARKFSAEEKAEA 1654
            :.|.:  |.|...:...:|.||:
  Rat  1711 HEEAEAVLAIPPNQPIVDESAES 1733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rictor	NP_573371.1	RICTOR_N	63..440	CDD:291336	139/381 (36%)
		RICTOR_M	583..798	CDD:291338	72/221 (33%)
		RasGEF_N_2	805..908	CDD:291335	36/104 (35%)
		RICTOR_V	977..1047	CDD:291340	26/69 (38%)
Rictor	XP_038959455.1	RICTOR_N	58..437	CDD:405367	138/381 (36%)
		RICTOR_M	637..740	CDD:405369	36/104 (35%)
		RasGEF_N_2	747..853	CDD:405366	37/105 (35%)
		RICTOR_V	922..991	CDD:405371	26/70 (37%)
		RICTOR_phospho	1085..1188	CDD:405368	13/102 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353120
Domainoid	1	1.000	277	1.000	Domainoid score	I1662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I785
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D128601at2759
OrthoFinder	1	1.000	-	-		FOG0005060
OrthoInspector	1	1.000	-	-		oto96428
orthoMCL	1	0.900	-	-		OOG6_103652
Panther	1	1.100	-	-	LDO	PTHR13298
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4097
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.990