DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rictor and ste20

DIOPT Version :9

Sequence 1:	NP_573371.1	Gene:	rictor / 32919	FlyBaseID:	FBgn0031006	Length:	1936	Species:	Drosophila melanogaster
Sequence 2:	NP_596021.1	Gene:	ste20 / 2539845	PomBaseID:	SPBC12C2.02c	Length:	1309	Species:	Schizosaccharomyces pombe

Alignment Length:	1179	Identity:	270/1179 - (22%)
Similarity:	501/1179 - (42%)	Gaps:	218/1179 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GKRSKLQLRIKVSQDPEDFYRLDPQRSAAENAFEIYSMLCLE-ETRDTKRLFLLNALASLCLGAR 74
            |||.. .|:...||.|     |:|.   .:|.::    .||| ..:|     ::::..:||....
pombe   199 GKRPS-SLQSNFSQFP-----LNPW---LDNIYK----ACLEGSMKD-----VIDSSNNLCEYLH 245

  Fly    75 KGS---HHSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCR 136
            :.|   :..|....|..:|..|..::    ::|.|:..|.:|:.............|.|..:|.:
pombe   246 EHSDPAYAKNFSLITPTILSMLELNV----SEVTASVYRLLRHLFLDATAFSCCQMLNLPWILSK 306

  Fly   137 SIDLMLKNDD----ERVQALKLVRKMLAIAP----EDISPAVVRCLVSLADSGIEENDNLLRACL 193
            |   :|...|    ||.||.:|:|.:..::.    ||....:.|.::|:.:   ..:|......:
pombe   307 S---LLSGTDAYQIEREQAFRLIRTLYFLSSTEGHEDYLSGITRTIISICE---HVSDVSRGIAV 365

  Fly   194 ATLAEFAVLNPALLIVCGGVTSITRNVLE-CHNPRIAESLCGVLLYLLEWPQTRNICGVRL---- 253
            .||.|..::.|.:|....|:..:..:::: ..:..:|.|....|:|||:.|:  :.|.|.|
pombe   366 ETLIELMIIRPKILFKANGLRVLMISLIDGSISENLAASAALALVYLLDDPE--SACYVNLPYDI 428

  Fly   254 DCLAAPYCDFTYR---QSIVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVD 315
            ..|.:|:...:.|   .|..::::.|.:...:|.::|.: :|.||:|.|.. ..:....|::|||
pombe   429 GILLSPFTSSSSRDTFNSSEEQSEQAAKAMKSSAKVASV-LLNSWSGLLAL-STNDFQALRSIVD 491

  Fly   316 ALYLNQIEVRKAILDLLYELLTLPQPTWTDDY-------AVALQAVDPSDFQDTWLLSNGFVSAE 373
            .|.:.....|..::||.:.:..:...:|::.:       .|..|||...|       :...|:
pombe   492 TLRVPSFAPRSDVIDLFFLIFQVEYSSWSESFLAGKRLTVVKNQAVSNDD-------NINMVN-- 547

  Fly   374 GRSILPTLAARAPSVVEQHL-ALMLYCFLETGLLNALVEVV-VSSDQFVSVQATVLIGKILQLMH 436
                :|..:.:....:.||. |::|:.|||.||:.::|.:: .|.|...|.:||.|:|::|:|..
pombe   548 ----IPDGSNKKYMSLRQHFTAVLLFIFLELGLVESIVCMIRASDDPSASRKATYLLGEVLRLSD 608

  Fly   437 THLPPDICCTSPALPTLVSHAT-LGNQQANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQ 500
            ..||..:.....:||:|.:.|: ...:....|.:.||:.:.|.|.:       ..|..|..:...
pombe   609 ELLPIHLGAKIQSLPSLFNMASQFTAEDRFVATSVLQSIESLNRVK-------FHSATQPFSQTT 666

  Fly   501 TRLFRRHLNVQEQAGPVLQLQETAEAAAFAVPPVTQFRG--TLDRSRLDSVSSSDESNSQASTSS 563
            :.||:.    |:..|                    .|||  .::..:|......|:|:
pombe   667 SLLFKE----QKTDG--------------------SFRGQRQVEHVKLKMGMQIDDSH------- 700

  Fly   564 RSSFRLKRKFLPQALYDNFRAFNRLLTDSRVLSQADAHLWDWDVITTILKSNLI--RKLDYT--Q 624
                                 |..:|.::.||:..:...|.||.:..|::..|:  :::|.|  .
pombe   701 ---------------------FRSMLAETNVLATKNYQKWRWDTLVQIMEGPLLSPKRIDETLRT 744

  Fly   625 GKFLKRLVDFYKPRNNRFSH-QDLVPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQ 688
            .||::||:.||||.:||||. |:..|.|:   ::..|..:...||::.  |.::::::  |.:.:
pombe   745 TKFMRRLLAFYKPFSNRFSSIQNTKPNQK---FIKVGCLVFRTLLANP--EGVKYLSE--SKVIK 802

  Fly   689 QLAAVTT-----SNRAHDCLFSPQHMNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINLVR 748
            |:|...:     |.:..:.:||...:..|:...||..:..:....:|..:::...:|..|.:|..
pombe   803 QIAESLSQIDGYSEQVSEPIFSNSRLQKTLTHGYFPMLKVLSSQKEGHAIMERWRIFTTLYHLTE 867

  Fly   749 VTDHVCYVKLIVSGLNYSYEKLPRQVLEKALTSAKTRGRLYSTQFMAVLLRA-----RLPHFEVW 808
            :.:....:.:.::.|:|..|...|.:..|||.:.:...||.:|:.:|.|:.:     .|.|   |
pombe   868 LRNRDDLIIIFLTNLDYRLEGHTRIIFSKALNTGQQAVRLTATKHLAALINSESANDNLNH---W 929

  Fly   809 GIPLIINQTRDSDRSVGLAAMDVLEEAC-HDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRG 872
            .|.|:|.|..|....|...|:.||.|.| .::..|.::|...|:|.|.|:.|..|:.|:.:...|
pombe   930 AISLLIFQLYDPCLEVCKTAVKVLNEVCARNENLLAQVVQLQPSLAHLGEIGSPLLLRFLATTVG 994

  Fly   873 LN--STMARIEDEIRYWRNGYNKRYVLLVEADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNVA 935
            .:  |.:..||.|:..|.:..|..||.|:|.:...|...:::..|      ..|..|.   .|:.
pombe   995 FHYLSEINFIEHELDNWYHHRNIDYVDLLEQNFFLSFVSNLKIID------KKNNEPD---ENIL 1050

  Fly   936 P-HLYGQMAQTGQGMTALRKHG-------------DLPQLLELLRRAKCTDDAECLELKAAIWAL 986
            | |.||::.::.||...|...|             |.|...|.:|           :||:|:||:
pombe  1051 PLHFYGELVKSPQGCEVLESSGHFESFMGTLVEFYDKPLGNEAIR-----------QLKSALWAI 1104

  Fly   987 AHASTHSNGIEYFVELNARLYEKLIVLVTKCE---VYSVRATCFSALGLIAGTQAGANILFKLNW 1048
            .:......||.:.:.     ::.:.::|...|   :.:||.|.:..||||:.|..|..||..|:|
pombe  1105 GNIGKTDQGITFLIN-----HDTIPLIVKYAENSLIPTVRGTAYFVLGLISRTSKGVEILESLHW 1164

  Fly  1049 LSVRHDKNTMWPVHQPEDWMSSQYTP---VRHYYEDVPA-------DNMTMMDDYIERFYETGSD 1103
            .|:.....|...:..|........||   |....|.||.       .::|..:..:.|.....|:
pombe  1165 YSLMSLMGTSQGICIPRHAGQVLSTPRRNVEFVNERVPTPEFSSLLSSLTNSEREVIRLVSNLSN 1229

  Fly  1104 FWHMLADQT 1112
              |:|.:::
pombe  1230 --HVLTNES 1236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rictor	NP_573371.1	RICTOR_N	63..440	CDD:291336	91/404 (23%)
		RICTOR_M	583..798	CDD:291338	54/224 (24%)
		RasGEF_N_2	805..908	CDD:291335	33/105 (31%)
		RICTOR_V	977..1047	CDD:291340	20/72 (28%)
ste20	NP_596021.1	HR1	34..108	CDD:294066
		RICTOR_N	237..612	CDD:291336	91/401 (23%)
		RICTOR_M	697..917	CDD:291338	56/254 (22%)
		RasGEF_N_2	926..1025	CDD:291335	33/101 (33%)
		RICTOR_V	1095..1163	CDD:291340	21/83 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I2436
eggNOG	1	0.900	-	-		E1_KOG3694
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I852
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005060
OrthoInspector	1	1.000	-	-		oto100915
orthoMCL	1	0.900	-	-		OOG6_103652
Panther	1	1.100	-	-	LDO	PTHR13298
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1404
SonicParanoid	1	1.000	-	-		X4097
TreeFam	0	0.000	Not matched by this tool.
	11	10.890