Protein Alignment rictor and RICTOR

DIOPT Version :10

• Sequence 1: NP_573371.1
• Gene: rictor / 32919
• FlyBaseID: FBgn0031006
• Length: 1936
• Species: Drosophila melanogaster
• Sequence 2: NP_001272368.1
• Gene: RICTOR / 253260
• HGNCID: 28611
• Length: 1732
• Species: Homo sapiens
• Alignment Length: 1862
• Identity: 514/1862 - (27%)
• Similarity: 830/1862 - (44%)
• Gaps: 347/1862 - (18%)

  Fly    13 RSKLQLRIKVSQDP-EDFYRLDPQRSAAENAFEIYSMLC-LEETRDTKRLFLLNALASLCLGARK 75
            ||...||::...|. |:...||..|..::|..||...:. |:...:.::|..||....|....
Human     8 RSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDI-- 70

  Fly    76 GSHHSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 140
            |.....:.|..|:::.||..:|::...:||||.||.:||.|...:.::....|::.:|:.|.||:
Human    71 GHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI 135

  Fly   141 MLKNDDERVQALKLVRKMLAIAPEDISPAVVRCLVSLADSGIEENDNLLRACLATLAEFAVLNPA 205
            ...|:.||.|||:|||||:.:.......:|...|:::.:.|::|.|.::|||:|.:.|.|:.||.
Human   136 QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPE 200

  Fly   206 LLIVCGGVTSITRNVLECHNPRIAESLCGVLLYLLEWPQTRNI--CGVRLDCLAAPYCDFTYRQS 268
            ::.:.||:.:|.:||::|...||.|:|...:|:||..|:||..  ..|.|:.:.|||.||.||.|
Human   201 VVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS 265

  Fly   269 ---IVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVDALYLNQIEVRKAILD 330
               ...:.|:.||.|:.:.::.:::..|||.|.:..|.|.. ||:::::..|.:..:|:|:.:|:
Human   266 PDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGN-SGIQSLIGVLCIPNMEIRRGLLE 329

  Fly   331 LLYELLTLPQPTWTDDYAVALQAVDPSDFQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLAL 395
            :||::..||.|..|:::..||.:|||..|||:|.||:|||:||.::|||..|...|.:::.:|||
Human   330 VLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLAL 394

  Fly   396 MLYCFLETGLLNALVEVVVSSDQFVSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHATL- 459
            :|..|:..|||..||||:.:||..:||:||:|:|::|.:.:|.||.........||||::.|..
Human   395 ILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASF 459

  Fly   460 -----GNQQANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQTRLFR-RHLNVQEQAGPVL 518
                 ...:|:||:..|:.:.::.::.|...||.||.|||  ..|.|...| ::|.||:.   :.
Human   460 DIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQ--KAIATHQKRDQYLRVQKD---IF 519

  Fly   519 QLQETAEAAAFAVPPVTQFRGTLDRSRLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFR 583
            .|::|.|                                                   ||..|.|
Human   520 ILKDTEE---------------------------------------------------ALLINLR 533

  Fly   584 AFNRLLTDSRVLSQADAHLWDWDVITTILK---SNLIRKLDYTQGKFLKRLVDFYKPRNNRFSHQ 645
                   ||:||...:...|:|::|.||||   .||....|....:|::||:.||||.:..:::.
Human   534 -------DSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANL 591

  Fly   646 DL--VPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQQLAAVTTSNRAHDCLFSPQH 708
            ||  ...::|..   .|....:.||.|.| :...::.|...||.|.|.|  :|....:.......
Human   592 DLDFAKAKQLTV---VGCQFTEFLLESEE-DGQGYLEDLVKDIVQWLNA--SSGMKPERSLQNNG 650

  Fly   709 MNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINL--VRVTDHVCYVKLIVSGLNYSYEKLP 771
            :..|:.|.|||:||.:.....|:::|:..:||:.|:||  ::..||:  :||.||.|:||.:.|.
Human   651 LLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHL--LKLTVSSLDYSRDGLA 713

  Fly   772 RQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEAC 836
            |.:|.|.||:|....|||:|:.:.|||||.:..|..|||.|::.|..|.::::...|:|:|:|||
Human   714 RVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEAC 778

  Fly   837 HDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRYVLLV 899
            .||..|..::...|.|:|.||.|.||:.|:.|:|:|.:....|  :..::..|...||.:||.|:
Human   779 EDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLI 843

  Fly   900 EADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNVAPHLYGQMAQTGQGMTALRKHGDLPQLLEL 964
            |...:.:||.:.:..||....|..|||.|.....:..|||||:.....|...|.....:.:|...
Human   844 EEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRN 908

  Fly   965 LRRAKCTDDAECLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVRATCFSA 1029
            :|........|..:|||::|||.:..:.:.|:....|.|  :...::.|..:|||.|:|.||...
Human   909 VRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEEN--VIPDILKLAKQCEVLSIRGTCVYV 971

  Fly  1030 LGLIAGTQAGANILFKLNWLSVRHDKNTMWPVHQPED---------------WMSSQYTPVRH-- 1077
            |||||.|:.|.:||...||.:|||.:..:||| .|:|               .::|:.|..||
Human   972 LGLIAKTKQGCDILKCHNWDAVRHSRKHLWPV-VPDDVEQLCNELSSIPSTLSLNSESTSSRHNS 1035

  Fly  1078 YYEDVPADNMTMMDDYIERFYETG-SDFWHMLADQT-----DASG------------GGGGVAGT 1124
            ..|.||:....:.||   ||..:. |.|:..:.:.|     |.||            ....|...
Human  1036 ESESVPSSMFILEDD---RFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNR 1097

  Fly  1125 VVG-------MHPIVQDPNATITTTDS------VRTTT---------DDVHPRMLVGVAAKSKTL 1167
            ::.       .|....||.....:::|      :||.|         ||..|     ::...|||
Human  1098 ILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTP-----ISTVQKTL 1157

  Fly  1168 PEGSNLRQGKHQRSLSESKTTDVIS----LLGSGVGTMSG---------AVLYPTPYQHRIRYNS 1219
            ...::....||   :.::.:|..|.    ......||.:.         .|...|....:||..|
Human  1158 QLETSFMGNKH---IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQS 1219

  Fly  1220 C-TDSNTSGVSSCESVTGRTAAAYAAAANELQQFPLSPIPSMSNLL-------ESDELFRRNQLA 1276
            . ||:.|||:||..|...|......|...:.....:|.:.|...:.       :|:.|......:
Human  1220 FNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNS 1284

  Fly  1277 TSMLP-------------------STLSPMA-----------MKGYVQLRSL-RKHSRPVFSESS 1310
            .|::|                   :|:..:|           ..||..|:.| ::...|..|.|.
Human  1285 VSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSE 1349

  Fly  1311 AEFYDFAEILDTPEVQMRKLDWTHSHRRLKVRSLDRQLSDV---YRRLSADELNVLLPTLNAPKF 1372
            |......::|.|..:.|            |..|.:.:|:..   :::.....:..|.||:....|
Human  1350 ALASPAKDVLFTDTITM------------KANSFESRLTPSRIDFKKKHVGGIRSLRPTITNNLF 1402

  Fly  1373 ----------LPPNDLKGPC-------------------------YAGICLPKNVLDLFPTRNLS 1402
                      |...||..|.                         |.|:.||.::.|:|..:::.
Human  1403 RFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIP 1467

  Fly  1403 RTYVSRDIQDQDIVGI-------------------NLLNTMLRPQCLNDSLTNEGGDESSVISSL 1448
             .:.:::|...|..|.                   |..:.:.:...|.:.:.:...|.|..:.|.
Human  1468 -YFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLEST 1531

  Fly  1449 SDVSSASRRQTRQLQQGAKHSRSLCLHC------ARSPRQQRNDSGSHSNGGGGASLAPCELYSS 1507
            .|..         ||:   |:...||:|      ...|..|.:...|||:    ....|   ||.
Human  1532 EDTG---------LQE---HTDDNCLYCVCIEILGFQPSNQLSAICSHSD----FQDIP---YSD 1577

  Fly  1508 AAAALVAAGIQAGPVLAKKSGSS--AQGASAALGADISFHSPESMLSEDSLPD-------RLTAS 1563
            .....:...::..|  :|.||.|  :.|.|.. |:..|..|.|.:|...::||       .|...
Human  1578 WCEQTIHNPLEVVP--SKFSGISGCSDGVSQE-GSASSTKSTELLLGVKTIPDDTPMCRILLRKE 1639

  Fly  1564 ILYNVQRLANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGRSSYRMIARRFLQELFLDL 1628
            :|..|..|::.||.|..:..||.:|:|:|..|.|||||||....:...::|:..|||:||||.|:
Human  1640 VLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV 1704

  Fly  1629 NFDSFYVEPQLIIGARKFSAEEKAEATAPTAMQAMPFKQTIL 1670
            .|               ....|:|||...|     |.||.|:
Human  1705 QF---------------LQMHEEAEAVLAT-----PPKQPIV 1726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rictor	NP_573371.1	RICTOR_N	63..440	CDD:464246	138/381 (36%)
		RICTOR_M	695..798	CDD:464248	36/104 (35%)
		RasGEF_N_2	805..908	CDD:464245	36/104 (35%)
		RICTOR_V	977..1048	CDD:464249	26/70 (37%)
RICTOR	NP_001272368.1	Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398	1..789		275/854 (32%)
		RICTOR_N	58..437	CDD:464246	137/381 (36%)
		Ribosome-binding domain. /evidence=ECO:0000305|PubMed:26176550	521..570		21/106 (20%)
		RICTOR_M	637..740	CDD:464248	36/104 (35%)
		RasGEF_N_2	747..853	CDD:464245	37/105 (35%)
		RICTOR_V	922..991	CDD:464249	27/70 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1041		5/18 (28%)
		RICTOR_phospho	1085..1188	CDD:464247	18/110 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1103..1134		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1204..1252		15/47 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1275..1298		3/22 (14%)