DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rictor and RICTOR

DIOPT Version :9

Sequence 1:NP_573371.1 Gene:rictor / 32919 FlyBaseID:FBgn0031006 Length:1936 Species:Drosophila melanogaster
Sequence 2:NP_001272368.1 Gene:RICTOR / 253260 HGNCID:28611 Length:1732 Species:Homo sapiens


Alignment Length:1862 Identity:514/1862 - (27%)
Similarity:830/1862 - (44%) Gaps:347/1862 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 RSKLQLRIKVSQDP-EDFYRLDPQRSAAENAFEIYSMLC-LEETRDTKRLFLLNALASLCLGARK 75
            ||...||::...|. |:...||..|..::|..||...:. |:...:.::|..||....|....  
Human     8 RSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDI-- 70

  Fly    76 GSHHSNIRFTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 140
            |.....:.|..|:::.||..:|::...:||||.||.:||.|...:.::....|::.:|:.|.||:
Human    71 GHSEEKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDI 135

  Fly   141 MLKNDDERVQALKLVRKMLAIAPEDISPAVVRCLVSLADSGIEENDNLLRACLATLAEFAVLNPA 205
            ...|:.||.|||:|||||:.:.......:|...|:::.:.|::|.|.::|||:|.:.|.|:.||.
Human   136 QQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPE 200

  Fly   206 LLIVCGGVTSITRNVLECHNPRIAESLCGVLLYLLEWPQTRNI--CGVRLDCLAAPYCDFTYRQS 268
            ::.:.||:.:|.:||::|...||.|:|...:|:||..|:||..  ..|.|:.:.|||.||.||.|
Human   201 VVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHS 265

  Fly   269 ---IVDKNKDARELRYTSCRLALLSVLRSWTGTLEFCDPSKPSGLKAIVDALYLNQIEVRKAILD 330
               ...:.|:.||.|:.:.::.:::..|||.|.:..|.|.. ||:::::..|.:..:|:|:.:|:
Human   266 PDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGN-SGIQSLIGVLCIPNMEIRRGLLE 329

  Fly   331 LLYELLTLPQPTWTDDYAVALQAVDPSDFQDTWLLSNGFVSAEGRSILPTLAARAPSVVEQHLAL 395
            :||::..||.|..|:::..||.:|||..|||:|.||:|||:||.::|||..|...|.:::.:|||
Human   330 VLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLAL 394

  Fly   396 MLYCFLETGLLNALVEVVVSSDQFVSVQATVLIGKILQLMHTHLPPDICCTSPALPTLVSHATL- 459
            :|..|:..|||..||||:.:||..:||:||:|:|::|.:.:|.||.........||||::.|.. 
Human   395 ILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASF 459

  Fly   460 -----GNQQANAAVAALQNYQKLLRQRPASRSLFLDSIIQGGALIQTRLFR-RHLNVQEQAGPVL 518
                 ...:|:||:..|:.:.::.::.|...||.||.|||  ..|.|...| ::|.||:.   :.
Human   460 DIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQ--KAIATHQKRDQYLRVQKD---IF 519

  Fly   519 QLQETAEAAAFAVPPVTQFRGTLDRSRLDSVSSSDESNSQASTSSRSSFRLKRKFLPQALYDNFR 583
            .|::|.|                                                   ||..|.|
Human   520 ILKDTEE---------------------------------------------------ALLINLR 533

  Fly   584 AFNRLLTDSRVLSQADAHLWDWDVITTILK---SNLIRKLDYTQGKFLKRLVDFYKPRNNRFSHQ 645
                   ||:||...:...|:|::|.||||   .||....|....:|::||:.||||.:..:::.
Human   534 -------DSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYANL 591

  Fly   646 DL--VPGQRLPTYVSAGLDLIDVLLSSNELECMRFITDYFSDISQQLAAVTTSNRAHDCLFSPQH 708
            ||  ...::|..   .|....:.||.|.| :...::.|...||.|.|.|  :|....:.......
Human   592 DLDFAKAKQLTV---VGCQFTEFLLESEE-DGQGYLEDLVKDIVQWLNA--SSGMKPERSLQNNG 650

  Fly   709 MNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINL--VRVTDHVCYVKLIVSGLNYSYEKLP 771
            :..|:.|.|||:||.:.....|:::|:..:||:.|:||  ::..||:  :||.||.|:||.:.|.
Human   651 LLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHL--LKLTVSSLDYSRDGLA 713

  Fly   772 RQVLEKALTSAKTRGRLYSTQFMAVLLRARLPHFEVWGIPLIINQTRDSDRSVGLAAMDVLEEAC 836
            |.:|.|.||:|....|||:|:.:.|||||.:..|..|||.|::.|..|.::::...|:|:|:|||
Human   714 RVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEAC 778

  Fly   837 HDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLNSTMAR--IEDEIRYWRNGYNKRYVLLV 899
            .||..|..::...|.|:|.||.|.||:.|:.|:|:|.:....|  :..::..|...||.:||.|:
Human   779 EDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLI 843

  Fly   900 EADTHSSLTLHIRNEDGYYSRRNCNQRPQTVPPNVAPHLYGQMAQTGQGMTALRKHGDLPQLLEL 964
            |...:.:||.:.:..||....|..|||.|.....:..|||||:.....|...|.....:.:|...
Human   844 EEQLNEALTTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRN 908

  Fly   965 LRRAKCTDDAECLELKAAIWALAHASTHSNGIEYFVELNARLYEKLIVLVTKCEVYSVRATCFSA 1029
            :|........|..:|||::|||.:..:.:.|:....|.|  :...::.|..:|||.|:|.||...
Human   909 VRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEEN--VIPDILKLAKQCEVLSIRGTCVYV 971

  Fly  1030 LGLIAGTQAGANILFKLNWLSVRHDKNTMWPVHQPED---------------WMSSQYTPVRH-- 1077
            |||||.|:.|.:||...||.:|||.:..:||| .|:|               .::|:.|..||  
Human   972 LGLIAKTKQGCDILKCHNWDAVRHSRKHLWPV-VPDDVEQLCNELSSIPSTLSLNSESTSSRHNS 1035

  Fly  1078 YYEDVPADNMTMMDDYIERFYETG-SDFWHMLADQT-----DASG------------GGGGVAGT 1124
            ..|.||:....:.||   ||..:. |.|:..:.:.|     |.||            ....|...
Human  1036 ESESVPSSMFILEDD---RFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFFASSKLVKNR 1097

  Fly  1125 VVG-------MHPIVQDPNATITTTDS------VRTTT---------DDVHPRMLVGVAAKSKTL 1167
            ::.       .|....||.....:::|      :||.|         ||..|     ::...|||
Human  1098 ILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDDFTP-----ISTVQKTL 1157

  Fly  1168 PEGSNLRQGKHQRSLSESKTTDVIS----LLGSGVGTMSG---------AVLYPTPYQHRIRYNS 1219
            ...::....||   :.::.:|..|.    ......||.:.         .|...|....:||..|
Human  1158 QLETSFMGNKH---IEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLVVESSTSSHMKIRSQS 1219

  Fly  1220 C-TDSNTSGVSSCESVTGRTAAAYAAAANELQQFPLSPIPSMSNLL-------ESDELFRRNQLA 1276
            . ||:.|||:||..|...|......|...:.....:|.:.|...:.       :|:.|......:
Human  1220 FNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTKTIKTSHYLTPQSNHLSLSKSNS 1284

  Fly  1277 TSMLP-------------------STLSPMA-----------MKGYVQLRSL-RKHSRPVFSESS 1310
            .|::|                   :|:..:|           ..||..|:.| ::...|..|.|.
Human  1285 VSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSE 1349

  Fly  1311 AEFYDFAEILDTPEVQMRKLDWTHSHRRLKVRSLDRQLSDV---YRRLSADELNVLLPTLNAPKF 1372
            |......::|.|..:.|            |..|.:.:|:..   :::.....:..|.||:....|
Human  1350 ALASPAKDVLFTDTITM------------KANSFESRLTPSRIDFKKKHVGGIRSLRPTITNNLF 1402

  Fly  1373 ----------LPPNDLKGPC-------------------------YAGICLPKNVLDLFPTRNLS 1402
                      |...||..|.                         |.|:.||.::.|:|..:::.
Human  1403 RFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIP 1467

  Fly  1403 RTYVSRDIQDQDIVGI-------------------NLLNTMLRPQCLNDSLTNEGGDESSVISSL 1448
             .:.:::|...|..|.                   |..:.:.:...|.:.:.:...|.|..:.|.
Human  1468 -YFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLEST 1531

  Fly  1449 SDVSSASRRQTRQLQQGAKHSRSLCLHC------ARSPRQQRNDSGSHSNGGGGASLAPCELYSS 1507
            .|..         ||:   |:...||:|      ...|..|.:...|||:    ....|   ||.
Human  1532 EDTG---------LQE---HTDDNCLYCVCIEILGFQPSNQLSAICSHSD----FQDIP---YSD 1577

  Fly  1508 AAAALVAAGIQAGPVLAKKSGSS--AQGASAALGADISFHSPESMLSEDSLPD-------RLTAS 1563
            .....:...::..|  :|.||.|  :.|.|.. |:..|..|.|.:|...::||       .|...
Human  1578 WCEQTIHNPLEVVP--SKFSGISGCSDGVSQE-GSASSTKSTELLLGVKTIPDDTPMCRILLRKE 1639

  Fly  1564 ILYNVQRLANPVSAKQSKMALLELKQKHPHAFQDICLYSEACKTIGRSSYRMIARRFLQELFLDL 1628
            :|..|..|::.||.|..:..||.:|:|:|..|.|||||||....:...::|:..|||:||||.|:
Human  1640 VLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDV 1704

  Fly  1629 NFDSFYVEPQLIIGARKFSAEEKAEATAPTAMQAMPFKQTIL 1670
            .|               ....|:|||...|     |.||.|:
Human  1705 QF---------------LQMHEEAEAVLAT-----PPKQPIV 1726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rictorNP_573371.1 RICTOR_N 63..440 CDD:291336 138/381 (36%)
RICTOR_M 583..798 CDD:291338 72/221 (33%)
RasGEF_N_2 805..908 CDD:291335 36/104 (35%)
RICTOR_V 977..1047 CDD:291340 26/69 (38%)
RICTORNP_001272368.1 Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 1..789 275/854 (32%)
RICTOR_N 60..437 CDD:291336 137/379 (36%)
RICTOR_M 525..740 CDD:291338 76/280 (27%)
RasGEF_N_2 747..853 CDD:291335 37/105 (35%)
RICTOR_V 922..989 CDD:291340 26/68 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1041 5/18 (28%)
RICTOR_phospho 1084..1188 CDD:291337 18/111 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1134 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1252 15/47 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1298 3/22 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159108
Domainoid 1 1.000 275 1.000 Domainoid score I1770
eggNOG 1 0.900 - - E1_KOG3694
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 605 1.000 Inparanoid score I938
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D128601at2759
OrthoFinder 1 1.000 - - FOG0005060
OrthoInspector 1 1.000 - - oto89305
orthoMCL 1 0.900 - - OOG6_103652
Panther 1 1.100 - - LDO PTHR13298
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1404
SonicParanoid 1 1.000 - - X4097
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.880

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