DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hs3st-B and NDST2

DIOPT Version :9

Sequence 1:	NP_001259702.1	Gene:	Hs3st-B / 32918	FlyBaseID:	FBgn0031005	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_003626.1	Gene:	NDST2 / 8509	HGNCID:	7681	Length:	883	Species:	Homo sapiens

Alignment Length:	267	Identity:	78/267 - (29%)
Similarity:	133/267 - (49%)	Gaps:	29/267 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LPDTLIIGVKKSGTRALLEFIRLHPDVRAA------GSEVHFFDR-HYQRGLRWYRHH--MPYTI 186
            ||..||:|.:|:||.|:..|:.|||.|.::      ..|:.||:. :|.:|:.||...  :|...
Human   603 LPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDFFPVPSNA 667

  Fly   187 EGQITMEKTPSYFVTKEVPQRVYHMNPATKLLIVVRDPVTRAISDYTQAASKKADMKLFEQLAFV 251
            ......||:.:||.::.||:|...:.|..|::.|:.:|..||.|.|....:..      :.:|..
Human   668 STDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHG------DPVALN 726

  Fly   252 NGSYSVVD-TNWGPVKI----------GVYARYLERWLLYFPLSQLLFISGERLIMDPAYEIGRV 305
            ...|.|:. ::..|:.:          |.|:.:|:|||.|:|..|||.:.|:.|..:||..:..:
Human   727 YTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQELRTNPAASMESI 791

  Fly   306 QDFLGLKRVVT-EKHFYFNATKGFPCLFKSEARSTPHCLGKTKGRNHPHIDPGAIERLREFYRPF 369
            |.|||:...:. .:...|:..|||.|......::  .|||::|||.:|.:|..:...|.:|:|..
Human   792 QKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKT--RCLGRSKGRRYPDMDTESRLFLTDFFRNH 854

  Fly   370 NNKFYQL 376
            |.:..:|
Human   855 NLELSKL 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hs3st-B	NP_001259702.1	Sulfotransfer_1	131..368	CDD:279075	75/257 (29%)
NDST2	NP_003626.1	HSNSD	25..514	CDD:314871
		Heparan sulfate N-deacetylase 2	41..597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..81
		Heparan sulfate N-sulfotransferase 2	598..883		78/267 (29%)
		Sulfotransfer_1	603..852	CDD:307022	75/256 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810