DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hs3st-B and NDST1

DIOPT Version :9

Sequence 1:	NP_001259702.1	Gene:	Hs3st-B / 32918	FlyBaseID:	FBgn0031005	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001534.1	Gene:	NDST1 / 3340	HGNCID:	7680	Length:	882	Species:	Homo sapiens

Alignment Length:	327	Identity:	91/327 - (27%)
Similarity:	140/327 - (42%)	Gaps:	78/327 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PPAQTVTSSLDGAPKY-QL-------LRQQGLRPSRH------------LPDTLIIGVKKSGTRA 146
            ||.|.       |.|| |:       |.|......||            .|..||||.:|:||.|
Human   562 PPVQL-------AQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTA 619

  Fly   147 LLEFIRLHPDVRA------AGSEVHFFDRH-YQRGLRWYRHHMPYTIEGQIT----MEKTPSYFV 200
            |..|:.:|||:.:      ...|:.||:.| |.:|:.||....|  |....|    .||:.:||.
Human   620 LYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFP--IPSNTTSDFYFEKSANYFD 682

  Fly   201 TKEVPQRVYHMNPATKLLIVVRDPVTRAISDY--------------------TQAASKKADMKLF 245
            ::..|:|...:.|..|:|.::.:|..||.|.|                    |..:...:.::..
Human   683 SEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRAL 747

  Fly   246 EQLAFVNGSYSVVDTNWGPVKIGVYARYLERWLLYFPLSQLLFISGERLIMDPAYEIGRVQDFLG 310
            :....|.|        |       ||.::||||..:..:|:|.:.|:.|..:||..:..||.|||
Human   748 QNRCLVPG--------W-------YATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLG 797

  Fly   311 LKRVVT-EKHFYFNATKGFPCLFKSEARSTPHCLGKTKGRNHPHIDPGAIERLREFYRPFNNKFY 374
            :...:. .|...|:..|||.|......::  .||||:|||.:|.:|..:...|:::||..|.:..
Human   798 VTNTIDYHKTLAFDPKKGFWCQLLEGGKT--KCLGKSKGRKYPEMDLDSRAFLKDYYRDHNIELS 860

  Fly   375 QL 376
            :|
Human   861 KL 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hs3st-B	NP_001259702.1	Sulfotransfer_1	131..368	CDD:279075	77/268 (29%)
NDST1	NP_001534.1	HSNSD	30..515	CDD:288882
		Heparan sulfate N-deacetylase 1	40..598		11/42 (26%)
		Heparan sulfate N-sulfotransferase 1	599..882		80/283 (28%)
		Sulfotransfer_1	605..855	CDD:279075	78/268 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810