DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Muc18B and IBSP

DIOPT Version :9

Sequence 1:	NP_001285431.1	Gene:	Muc18B / 32913	FlyBaseID:	FBgn0031000	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_004958.2	Gene:	IBSP / 3381	HGNCID:	5341	Length:	317	Species:	Homo sapiens

Alignment Length:	270	Identity:	59/270 - (21%)
Similarity:	92/270 - (34%)	Gaps:	42/270 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LTMLMGLALILAPSTIQAKSLCRSSGYFALVDNTPDFYACQSTAYGGYSLRFLRCPAGLVFSSSM 68
            |..::|:|...:...:..:.....|....:....|.:|..:...:..:..||   |......||.
Human     7 LLSILGMACAFSMKNLHRRVKIEDSEENGVFKYRPRYYLYKHAYFYPHLKRF---PVQGSSDSSE 68

  Fly    69 AQCVQSIAAFEARDDSNIENPTIPPSNLDESTTEKPATEAPGTTEKVTT------AAPGT----- 122
            .....|....|..::::.|......||.||.      :||..||...||      |.|||
Human    69 ENGDDSSEEEEEEEETSNEGENNEESNEDED------SEAENTTLSATTLGYGEDATPGTGYTGL 127

  Fly   123 -TEKVTTEAPGTTEKITTEAPGTTEKITTEAPGTTEKITTEAPGTTEKITTEAPGTTEKPATDAP 186
             ..::..:|...|.|.|.|.....|:...|.....|:...|.....:.|...:..:||  |.:..
Human   128 AAIQLPKKAGDITNKATKEKESDEEEEEEEEGNENEESEAEVDENEQGINGTSTNSTE--AENGN 190

  Fly   187 GTT---------EKPATDAPGTTEKSETTDAPGTTDKSDTDAPITDEPSTAETSTDEPNTETTES 242
            |::         |:..|.|     .:|.|...|...|..:..  |..|:.....|..|....|.|
Human   191 GSSGGDNGEEGEEESVTGA-----NAEDTTETGRQGKGTSKT--TTSPNGGFEPTTPPQVYRTTS 248

  Fly   243 ---GEETTIE 249
               |:.||:|
Human   249 PPFGKTTTVE 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc18B	NP_001285431.1	CBM_14	26..72	CDD:279884	8/45 (18%)
Muc18B	NP_001285431.1	MCLC	<77..177	CDD:283562	26/111 (23%)
IBSP	NP_004958.2	BSP_II	17..314	CDD:283165	56/260 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..254		49/213 (23%)
		cell-attachment tripeptide	286..288
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900