DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc18B and HCG22

DIOPT Version :9

Sequence 1:	NP_001285431.1	Gene:	Muc18B / 32913	FlyBaseID:	FBgn0031000	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001335178.1	Gene:	HCG22 / 285834	HGNCID:	27780	Length:	251	Species:	Homo sapiens

Alignment Length:	172	Identity:	78/172 - (45%)
Similarity:	89/172 - (51%)	Gaps:	14/172 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DSNIENPTIPPSNLDESTTEKPATEAPGTTEKVTTAAPGTTEKVTTEAPGTTEKITTEAPGTTEK 147
            ||.|....:   ..|..|||...|..|||||...||.|||||...|..|||||...|..|.||:.
Human    80 DSRIRENDV---TADGRTTEDHITADPGTTEDSVTADPGTTEDNVTVDPGTTEGSVTADPATTKD 141

  Fly   148 ITTEAPGTTEKITTEAPGTTEKITTEAPGTTEKPATDAPGTTEKPATDAPGTTEKSETTDAPGTT 212
            ..:..||||:...|..|||||...|..||||:...|..|.|||...|..||||:.|.|.| ||||
Human   142 YVSADPGTTKDSVTADPGTTENFVTADPGTTKDSITADPRTTEDSVTADPGTTKHSITVD-PGTT 205

  Fly   213 DKSDTDAP------ITDEPSTAETS-TDEPNT---ETTESGE 244
            :.|.|..|      ||.:|.|.|.| |.:|.|   |||:.|:
Human   206 EDSVTADPGTTKHSITADPGTTEDSVTADPGTTEDETTKHGD 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc18B	NP_001285431.1	CBM_14	26..72	CDD:279884
Muc18B	NP_001285431.1	MCLC	<77..177	CDD:283562	42/93 (45%)
HCG22	NP_001335178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..251		78/172 (45%)
		LGT	<83..248	CDD:320995	76/169 (45%)
		15 X 11 AA approximate repeats	153..251		44/96 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto89138
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940