DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Muc18B and T24E12.10

DIOPT Version :9

Sequence 1:	NP_001285431.1	Gene:	Muc18B / 32913	FlyBaseID:	FBgn0031000	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_494646.2	Gene:	T24E12.10 / 188866	WormBaseID:	WBGene00020777	Length:	1318	Species:	Caenorhabditis elegans

Alignment Length:	246	Identity:	48/246 - (19%)
Similarity:	86/246 - (34%)	Gaps:	74/246 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 QSIAAFEARDDSNIENPTIPP--SNLDESTTEKP-----------ATEAPGTTEKVTTAAPGT-- 122
            |.:..:||.||:::...::.|  .:...:||.:|           |.:.|..:  |.|.|..:
Worm   355 QEVQDYEAEDDNDLSAQSVAPVAESFSSATTSEPQEIVEIQEHHAAHQLPAVS--VATFAETSDN 417

  Fly   123 --TEKVTTEAP----------GTTEKITTEAPGTTEKI----TTEAPGTTEKITTEAPGTTE--- 168
              |::::.|||          ...|:|:....|....:    |:::|...:.:..:.....:
Worm   418 KATDEMSMEAPDDHQFSIHWVSNFEEISFSPDGYNSLMDPLETSQSPEVRDYVNEDGHDFCDSLI 482

  Fly   169 --KITTEAPGTTEKPATDAPGT----------------------------TEKPAT-DAPGTTEK 202
              |..:::....|..|.||..:                            :..||: |||  .|:
Worm   483 KPKELSQSTKVREAQAEDAAPSVSPNYEASLASDEALCEIVVEVQEDRQFSSSPASHDAP--IEQ 545

  Fly   203 SETTDAPGTTDKSDTDAPITDEPSTAETSTDEPNTETTE--SGEETTIEDN 251
            .||:.:|......|.:|......|.|.......|.||..  |.|   :.||
Worm   546 QETSQSPENQYDIDEEAHHLSTQSVAPVKAFLANDETPHEISAE---VHDN 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Muc18B	NP_001285431.1	CBM_14	26..72	CDD:279884
Muc18B	NP_001285431.1	MCLC	<77..177	CDD:283562	23/135 (17%)
T24E12.10	NP_494646.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900