DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ulp1 and Senp3

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_001157043.1	Gene:	Senp3 / 80886	MGIID:	2158736	Length:	568	Species:	Mus musculus

Alignment Length:	676	Identity:	133/676 - (19%)
Similarity:	230/676 - (34%)	Gaps:	183/676 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   868 TGTGFQAQNGKGFGAGRQ----PENSFLSQKRRNQEENPRLIKYRRVDNSFPRLITNETAEDLIP 928
            :|.||....|.|.....:    |..||.:.....:||.                 ..|..|::..
Mouse    42 SGGGFGPDPGSGTTVPTRRLPAPRPSFDASASEEEEEE-----------------EEEDEEEVAA 89

  Fly   929 NNSMAKRDQPQSSKRLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYSDAV 993
            .....:..|..:|:|.....|    .||              :..|||...|..:.:.:.||.:.
Mouse    90 WRLPPRWGQLGASQRSRALRP----SHR--------------KTCSQRRRRAMRAFQMLLYSKST 136

  Fly   994 RLGHNGISESRVNGHSSHTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPGTP 1058
            .|..:.....|..|             .|..|:|..|                     :|.|
Mouse   137 SLTFHWKLWGRHRG-------------RRRNLAHPKN---------------------HLSP--- 164

  Fly  1059 PTFQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPKR 1123
               |...|.....|.|.          .|.||.|...|.|.....|: .::......|.|..|..
Mouse   165 ---QEGGATPQVPSPCC----------RFDSPRGLPPPRLGLLGALM-AEDGMRGSPPVPSGPPM 215

  Fly  1124 NASNSSASHASTIS-SSASSSCS-------------------------TCSTCSSSDTEPMLVKD 1162
            .......:..|.:. .|...||:                         ..:.||..|      ..
Mouse   216 EEDGLRWTPKSPLDPDSGLLSCTLPNGFGGLSGPEGERSLAPPDASILISNVCSIGD------HV 274

  Fly  1163 SPEVKEANEANEANEANEANETKENDAPQPTTTRIKKPDFLHRRFANCI-FLRNDFAENFKARAN 1226
            :.|:.::::...|.||:...|.....:|            |......|: .:.::|.:.:.:
Mouse   275 AQELFQSSDLGIAEEADRTGEKAGQHSP------------LREEHVTCVQSILDEFLQTYGS--- 324

  Fly  1227 RRQLESMHLLGIAEQQANESKDERLAYEKKLREVMFRSGAPHRPFFEIGPLEQPEEKKETKLIPL 1291
                    |:.::..:..|          ||.::..:              |.....:::.::.|
Mouse   325 --------LIPLSTDEVVE----------KLEDIFQQ--------------EFSTPSRKSLVLQL 357

  Fly  1292 TKEDHARFQEMTTIEVTTNLIFKYNLQI-TTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGE 1355
            .:.    :|.|....:.......|...: |.||:.|.....||||.::|.|..::.:...::
Mouse   358 IQS----YQRMPGNAMVRGFRVSYKRHVLTMDDLGTLYGQNWLNDQVMNMYGDLVMDTVPEK--- 415

  Fly  1356 LPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYD 1420
               .:..|:||..:|...||.||:|||:.||:|:|:::.:|:|. .|||.:..:.:|.:||.|:|
Mouse   416 ---VHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELLLIPIHL-EVHWSLISVDVRRRTITYFD 476

  Fly  1421 SMGRPNQPALDALVKYLHEESLDKRKQPFDMTGFVVENAQNIPRQGNSSDCGVFSCMFAEYITRD 1485
            |....|:.....:.|||..|::.|.:..|.. |:......|:.||.|.||||.|...:.:::...
Mouse   477 SQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQ-GWKGYFKMNVARQNNDSDCGAFVLQYCKHLALS 540

  Fly  1486 VPITFSQAEMLYFRTKMALEIADGKL 1511
            .|.:|:|.:|...|.::..|:...||
Mouse   541 QPFSFTQQDMPKLRRQIYKELCHCKL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	54/174 (31%)
Senp3	NP_001157043.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		19/111 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	119..122		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	147..153		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..174		7/45 (16%)
		Protease	380..537		53/164 (32%)
		Peptidase_C48	394..566	CDD:280975	55/179 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850