DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Senp7

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_079759.2	Gene:	Senp7 / 66315	MGIID:	1913565	Length:	1037	Species:	Mus musculus

Alignment Length:	1007	Identity:	190/1007 - (18%)
Similarity:	305/1007 - (30%)	Gaps:	431/1007 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   825 PPRPTPKRDLQEDISMGLEILKKIRGMLSG--WYSSRESETDSTDTGTGFQAQNGKGFGAGRQPE 887
            ||:..|||.|              |.||:.  |          ||.|..|:
Mouse    82 PPKGLPKRHL--------------RVMLTNVLW----------TDLGREFR-------------- 108

  Fly   888 NSFLSQKRRNQEENPRLIKYRRVDNSFPRLITN-----ETAEDLIPNNSMAKRDQPQSSKRLSIF 947
                                    .:.||...|     :...|.:|:.|:   |..::.:||.
Mouse   109 ------------------------KTLPRKDANLCAPSKVQSDSLPSTSV---DSIETCQRLD-- 144

  Fly   948 NPPVYTQHRVRNDAPHV-PTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISES-------- 1003
              |::....:....|.| .|.....|..::.....|.:. .:.||...|....:|.|
Mouse   145 --PLHQSLNLSERTPRVILTDIRQTELGRKYLKIPPVTE-ASLSDTANLKSEQLSSSSDGSLESC 206

  Fly  1004 -RVNGHSSHTVRR--EPSRLHRSILSHEMNCKDQEQYNELIRT-----------QTNYVGSRYLK 1054
             .||.|.|.....  :|||. ..:.:.|..|..|:|.::...|           .|...|..||:
Mouse   207 QSVNHHKSFLSESGPKPSRT-GDVPAKEAACGGQKQGDDGGVTPEMAAPHPKDFNTGNKGCDYLE 270

  Fly  1055 PGTPPTFQRAKAQSATSSSCSLQDN-----------QSNITDSF--------PSPHGRANPELTE 1100
            .||        :...||.|.|..|:           :||..||.        |:.|.:.....:.
Mouse   271 EGT--------SNKNTSYSYSEMDHTPVSRKRKKRGRSNFHDSHNSKTSLDKPTEHTKEEENDSS 327

  Fly  1101 YAKLINRQENEENRSPAP----------------------QQPKRNASNSSASHAS-TISSSASS 1142
            .::.:.....:.::.|||                      |:|..:|::..||..: ::.|||||
Mouse   328 VSRKLEESGEDSHQDPAPPEGLAPESLESEATNLRSFAAGQEPDASAASGRASSPNKSLESSASS 392

  Fly  1143 SCSTCSTCS----------------SSDTEPMLVKDSPEVKEANEANEANEANEA---------- 1181
            ..|..|:.:                ||:...:|:...|.|..::|.......|..
Mouse   393 EVSENSSVAVKGEALTLKEASPPGGSSEESQLLISAEPIVVSSDEEGPVEHKNSVILKLQPPHEI 457

  Fly  1182 -NETKENDAPQ----------------------PTTTRIK----------KPDFL---------- 1203
             :|.:....||                      |....|.          |.||:
Mouse   458 MSENQGTSDPQLSELTLGACESVQVTSELFPYNPDVENISCIKSNSEMDLKLDFIFTCVYIGKIK 522

  Fly  1204 ----------------------------------------------HRRFANCI---FLRNDFAE 1219
                                                          |.:.::.|   :|.:|:.:
Mouse   523 GTPKGCVTFTKKYIKIPFQVSTNEISLTVDTARLKRFGLWESKDEDHSKRSHAILFLWLSSDYLQ 587

  Fly  1220 NFKARANRRQLESMHLLGIAEQQANE----------SKDERLAYEKKLREVMFRSGAPH----RP 1270
            :.:.     |||:..|  ..:.:|||          |:.|.|..:..:.|:..::|..|    .|
Mouse   588 DIQT-----QLENPML--SQQSKANEFIFLELNSSISQREELKLKDIMMEISTKNGNLHLSCPLP 645

  Fly  1271 FFEIGPLEQ---PEE----------------------KKETKLIP-------------------- 1290
            :.:..||.|   |:|                      ||::...|
Mouse   646 WVQALPLFQDLSPQEISFLHYYYASASALPTAAGADMKKKSVSQPSNSDTIKPTYTFLHKQSSGC 710

  Fly  1291 ----LTKEDHARFQEMTTIEVTTNLIF------KYNLQITTDDIFTFVDGEWLNDAIINFYMSML 1345
                :|......:||:........||.      |..|.:|.:|:....:||:|||.||:||:..|
Mouse   711 YSLSITSSPEEEWQEVRNTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYL 775

  Fly  1346 TERSEKRAGEL-PATYAMNTFFMPRL----------------LQAGYAGVRRWTRKVDLFSKDII 1393
            .  .||.:.|| ..::..::||...|                .|..:..||.|||.:::|:||.|
Mouse   776 L--LEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPDLSVAQRRHRRVRTWTRHINIFNKDYI 838

  Fly  1394 PVPVHCGNVHWCMAII---------------------------HLRNKT---------------- 1415
            .|||: .:.||.:|:|                           |....|
Mouse   839 FVPVN-ESSHWYLAVICFPWLEEAVYEDCPQTVSQQFQGQQSQHDHKMTDNDPHTTSTVSTSAED 902

  Fly  1416 -------------------IFYYDSMGRPN-QPALDALVKYLHEESLDKRK--QPFDMTGFVVEN 1458
                               |...||:...: |..:..|.:||..|...|||  :.|..|. :|:.
Mouse   903 SQSTEVNMSVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTN-MVDL 966

  Fly  1459 AQNIPRQGNSSDCGVFSCMFAEYITRDVPITF 1490
            ...:|:|.|||||||:...:.|...:|..:.|
Mouse   967 CPKVPKQDNSSDCGVYLLQYVESFFQDPIVNF 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	61/242 (25%)
Senp7	NP_079759.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..399		48/222 (22%)
		ULP1	<743..1033	CDD:227489	66/260 (25%)
		Protease. /evidence=ECO:0000250	747..1037		65/256 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..909		2/35 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810