DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and SENP2

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_067640.2	Gene:	SENP2 / 59343	HGNCID:	23116	Length:	589	Species:	Homo sapiens

Alignment Length:	695	Identity:	175/695 - (25%)
Similarity:	268/695 - (38%)	Gaps:	219/695 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   904 LIKYRRVDNS-FPRLITNETAEDLIPNNSMAKRDQPQSSKRLSIFNPPVYTQHRVRNDAPHVPT- 966
            |:|.||.|:: |..:.|:|     ||    |||      .||..|      .|:|:|...:..:
Human    26 LLKRRRSDSTLFSTVDTDE-----IP----AKR------PRLDCF------IHQVKNSLYNAASL 69

  Fly   967 ---PFD------------------------DEESSQRLANAGPSSRPMTYSDAVRLGH---NGIS 1001
               ||.                        ...||..|..:|      ::::.::||:   ||||
Human    70 FGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSG------SWNNMLKLGNKSPNGIS 128

  Fly  1002 E---SRVNGHSSHTVRREPSRLHRSI---LSHEMNCKDQEQYNELIRTQTNYVGSRYLKPGTPPT 1060
            :   .||.     ..|.:|.|:..|.   |:.| .|..:.             |.|....|.|.:
Human   129 DYPKIRVT-----VTRDQPRRVLPSFGFTLNSE-GCNRRP-------------GGRRHSKGNPES 174

  Fly  1061 FQRAKAQSATSSSCSLQDNQSNITDSFPSPH-----GRANPELTEYAKLINR-QENEENRSPAPQ 1119
            ....|.|....:....:::...:.    .||     |....|..:|.||:.| :|:....|..|
Human   175 SLMWKPQEQAVTEMISEESGKGLR----RPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCP- 234

  Fly  1120 QPKRNASNSSASHASTISS-------------------------SASSSCS-----TCSTCSSSD 1154
             ...|..:|..|...|:.:                         :....||     .||....:|
Human   235 -VTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITD 298

  Fly  1155 TEPMLVKDSPEVKEANEANEANEANEANETKENDAPQPTTTRI-----------KKPDFLHRRFA 1208
            ||.|:     .::..||:....:.       |.|..:..:.|:           :|...:..:..
Human   299 TETMV-----GIRFENESRRGYQL-------EPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEK 351

  Fly  1209 NCIFLRNDFAENFKARANRRQLESMHLLGIAEQQANESKDERLAYEKKLREVMFRSGAPHRPFFE 1273
            ||             ....|...:..||.:.|..           ||::...:     .|.|..|
Human   352 NC-------------SGKERDRRTDDLLELTEDM-----------EKEISNAL-----GHGPQDE 387

  Fly  1274 IGPLEQPEEKKETKLIPLTKEDHARFQEMTTIEVTTNLIFKYNLQITTDDIFTFVDGEWLNDAII 1338
            |                                    |...:.|:||..||.|..:..||||.:|
Human   388 I------------------------------------LSSAFKLRITRGDIQTLKNYHWLNDEVI 416

  Fly  1339 NFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVH 1403
            ||||::|.||::|:.  .||.:..:|||.|:|...||..|:|||:.|:||.::||.||:| ..||
Human   417 NFYMNLLVERNKKQG--YPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIH-RKVH 478

  Fly  1404 WCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYLHEESLDKRKQPFDMTGFVVENAQ--NIPRQG 1466
            |.:.:|.||.|.:.|.||||:......:.|::||.:||..||....::..:...:.:  .||:|.
Human   479 WSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQL 543

  Fly  1467 NSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKL 1511
            |.||||:|:|.:|:||:||.||||:|.:|..||.||..||...:|
Human   544 NGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	78/176 (44%)
SENP2	NP_067640.2	Nuclear localization signal. /evidence=ECO:0000269\|PubMed:16738331	28..31		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:16738331	46..51		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..176		6/34 (18%)
		Nuclear export signal	317..332		3/21 (14%)
		ULP1	<384..589	CDD:227489	91/244 (37%)
		Protease	396..560		70/166 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145969
Domainoid	1	1.000	191	1.000	Domainoid score	I3244
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2988
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8505
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.760