DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ulp1 and senp2

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	XP_684283.2	Gene:	senp2 / 556400	ZFINID:	ZDB-GENE-060810-183	Length:	598	Species:	Danio rerio

Alignment Length:	731	Identity:	174/731 - (23%)
Similarity:	274/731 - (37%)	Gaps:	229/731 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   821 TKEIPPRPTPKRDLQEDISMGLEILKKIRGMLSGWYSSR-----ESETDSTDTGTGFQAQNG--- 877
            |..:...|..||...:.|   :.::||....::|.:.||     |.|..:..|..|.....|
Zfish    59 TDGVSEYPEVKRARHDVI---VRVVKKTFAGIAGLFRSRVHRKAEHEKQNAFTQVGRVTFMGIDD 120

  Fly   878 ----------KGFGAGRQPENSFLSQKR--RNQEENPRLIKYRRVDNSFPRLITNETAEDLIPNN 930
                      :..|..:|.|....:::|  .|.:.||:.::.                    |:.
Zfish   121 IYSNSLSSWIESDGMDKQMEMGLKNKERTAANMQTNPQALRK--------------------PDG 165

  Fly   931 SMAKRDQPQSSKRLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRL 995
            :|..:.....|:.:             |.....||:
Zfish   166 TMLYKTNQDRSREM-------------RRSLKLVPS----------------------------- 188

  Fly   996 GHNGISESRVNGHSSHTVRRE-PSRLHRSILSHE--MNCKDQEQYNELIRTQTNYVGSRYLKPGT 1057
                   ...||.:|.....| |||..:..|:.|  :...|:|.|.:|:    .....:|.|
Zfish   189 -------CTTNGLNSRQAEMELPSRTPKPCLTVEEALRESDREHYRKLV----EMASEKYSK--- 239

  Fly  1058 PPTFQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPK 1122
                                        |.|.|.||..|.:|.:              |..
Zfish   240 ----------------------------SKPLPFGRIKPSITAF--------------PID---- 258

  Fly  1123 RNASNSSASHASTISSSASSSCSTCSTCSSSDTEPMLV-------KDSPEVKEANEAN-EANEAN 1179
                          ....|...|.|.|...:...|:.|       :|...:.:..:.. :.:.:.
Zfish   259 --------------GHKVSGHTSICRTTDLNRPAPVRVIPNISMWRDPLSLTQIKDRTVDGHRST 309

  Fly  1180 EANETKENDAPQPTTTRIKKPDFLHRRFANCIFLRNDFAENFKARANRRQLESMHLLGIAEQQAN 1244
            ..::.||......||          |:.|..:    |.:...:||.|.:..:|...|.|..:.
Zfish   310 TGSDVKEGALDNQTT----------RKTAVDV----DLSAEVEARLNLKDKDSAVGLLIPSRS-- 358

  Fly  1245 ESKDERLAYEKKLREVMFRSGAPHRPFFEIGPLEQPEEKKETKLIPLTKEDHARFQEMTT--IEV 1307
                          ||:  :.|..|     |..|.|.         ||||..   ||::.  .:.
Zfish   359 --------------EVI--TDAVRR-----GEEEFPR---------LTKEMQ---QEVSAALAQS 390

  Fly  1308 TTNLIF--KYNLQITTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRA-GELPATYAMNTFFMPR 1369
            ..||:.  .:.|:||..|:.|..:|.||||.:|||||:::..|||:.. |:  ..|:.:||..|:
Zfish   391 DPNLVLCSAFKLRITQRDLATLQEGSWLNDEVINFYMNLVMARSEQEVLGK--KVYSFSTFLFPK 453

  Fly  1370 LLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPALDALV 1434
            ||..|:|.|||||:.||||..|:|.||:|.| |||.:|::..::|::..|||||:.:....|.::
Zfish   454 LLSGGHAAVRRWTKAVDLFLFDVILVPLHLG-VHWSLAVVDFKSKSVRSYDSMGQRHDDICDLIL 517

  Fly  1435 KYLHEESLDKRKQPFDMTGFVVENAQ--NIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEMLY 1497
            .||.||...|:.:..|::.::|.:.:  .||:|.|.||||||.|.:|:||:|...:||.|..|.|
Zfish   518 LYLKEEFKVKKGKDLDVSKWIVSSLRPSEIPQQKNGSDCGVFICKYADYISRGRNLTFRQNHMPY 582

  Fly  1498 FRTKMALEIADGKLWQ 1513
            ||..|..||.:.||.|
Zfish   583 FRKAMIWEILNQKLLQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	77/177 (44%)
senp2	XP_684283.2	Peptidase_C48	<370..595	CDD:304959	95/239 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3201
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm6494
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880