DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Semp2l1

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_001157758.1	Gene:	Semp2l1 / 408191	MGIID:	3644687	Length:	478	Species:	Mus musculus

Alignment Length:	491	Identity:	134/491 - (27%)
Similarity:	219/491 - (44%)	Gaps:	89/491 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1063 RAKAQSATSSSCSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPK----- 1122
            :.|.|..|:....:......:|...|       |:|....:..::.:..:::...|.|||
Mouse    34 KRKCQDGTTMVFKVPGKAQKMTPQEP-------PDLELAIEQFSKGQVRKSQGETPNQPKPLELT 91

  Fly  1123 ----------RNASNSSASHASTISSSASSSCSTCSTCSSSDTEPMLVKDSPE----------VK 1167
                      |..::|...|....|             :..:.|.:..|:...          :|
Mouse    92 EGPPEQVVTGRAPADSGKGHKRPYS-------------AMEENEQIPQKEKKRRLLQNLKLILIK 143

  Fly  1168 EANEANEANEANEANETKENDAPQPTTTRIKK----PDFLHRRFANCIFLRNDFAENFKA----- 1223
            ........:|.:..:||...| |:|:|....|    ||...:    |.|......|....
Mouse   144 AGKIKGGESEDSHGSETTLRD-PEPSTVVALKECLSPDEREK----CCFEETSVTEKKGCVKVEG 203

  Fly  1224 -RANRRQLESMHLLGIAEQQANE---SKDERLAYEKKLREVMFRSGAPHRPFFEIGPLEQPEEKK 1284
             |.|..:..:...:.:...:.|.   :|...||.:||    ..|....||...:|..:.:..||:
Mouse   204 RRGNSLEPGTQAQIILDSSRGNSLLPNKMAVLAAQKK----PLRDHEKHREMDQILDITEDMEKE 264

  Fly  1285 -ETKLIPLTKEDHARFQEMTTIEVTTNLIFKYNLQITTDDIFTFVDGEWLNDAIINFYMSMLTER 1348
             |..|.|..:|           |:.::   ::.|.||..||.|..:|:||||.:|||||::|.||
Mouse   265 IENALGPGPQE-----------EILSS---RFKLLITRGDIQTLKNGQWLNDEVINFYMNLLVER 315

  Fly  1349 SEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRN 1413
            :|.:.  .||.:..:|||.|:|..:||:.|:||||.::||.|::|.||:| ..:||.:.:|.||.
Mouse   316 NENQG--YPALHVFSTFFYPKLKHSGYSSVKRWTRGINLFEKELILVPIH-QRLHWSLVVIDLRK 377

  Fly  1414 KTIFYYDSMGRPNQPALDALVKYLHEESLDKRK---QPFDMTGFVVENAQNIPRQGNSSDCGVFS 1475
            ::|.|:||:|:..:...:.:.:||..||..:|.   .|.:...:.:. ::.||.|.|.||||:|:
Mouse   378 QSIAYFDSIGQTGKSICETIFQYLQNESKTRRNIELDPLEWKQYSMA-SEEIPLQMNGSDCGMFT 441

  Fly  1476 CMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKL 1511
            |.:|:||.||.|:||||..|..||.:|..||...:|
Mouse   442 CKYADYIARDQPVTFSQQHMPTFRKRMVWEILHSQL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	74/177 (42%)
Semp2l1	NP_001157758.1	Peptidase_C48	<231..473	CDD:304959	98/263 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836053
Domainoid	1	1.000	189	1.000	Domainoid score	I3284
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8739
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.800