DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Senp5

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_001344016.1	Gene:	Senp5 / 320213	MGIID:	2443596	Length:	749	Species:	Mus musculus

Alignment Length:	796	Identity:	167/796 - (20%)
Similarity:	291/796 - (36%)	Gaps:	221/796 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   872 FQAQNGKGFGAGRQ---PEN-SFLSQKRRNQEENPRLIKY------------------------- 907
            |..:...|||:.::   |:| .||..|........|.:|:
Mouse    17 FSEKWNAGFGSFKKFYFPQNLCFLKAKLGRPVAWHRQVKHFQCNKGLHIQKTWIQDVPFCSKTKS 81

  Fly   908 ----RRVDNSFPRLITNETAEDLIPNNSMAKRDQPQSSKRLS---------------IFNPPVYT 953
                :.|...:|::...::...:..:.|:.|.   |:.|.||               :...|..:
Mouse    82 GLATQNVSTLYPKVKRKDSKHFISSSRSLLKL---QADKLLSSAKSLDHKYCREKSLLKAAPGLS 143

  Fly   954 QHRVRNDA-PHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESRV-----NGHSSHT 1012
            .:.|...| .|.||. |.:.|...:..:|.|..|......|.|..:   ..||     .|...|.
Mouse   144 ANTVLGRANGHEPTT-DPQASDFPMKFSGESQSPGDSGKTVVLNKH---RKRVCHGCYQGLEHHR 204

  Fly  1013 VRR----------EPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKPGTPPTFQRAKAQ 1067
            .||          :..|:..|::.:|.....:.:| .:.|:|.....||..|....   ||:..|
Mouse   205 NRRPLIPKQFQLNQHRRVRASLMMYEKLSMIRFRY-RIFRSQHFRTKSRVCKLRKA---QRSWVQ 265

  Fly  1068 SATSSSCSLQDNQSNITDS----------------------------------------FPSPHG 1092
            ..|.      |:|.|:.|:                                        .|..|.
Mouse   266 KVTG------DHQENLRDNNTEGDNCNPVPSLEPKDPCRCQPYFPDMDSSAVGKGKNCHVPDGHT 324

  Fly  1093 RANPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASHASTISSSASSSCSTCSTCSSSDTE- 1156
            :.||       :::::...::..|..|       |...::    :...||||.... |:....|
Mouse   325 KENP-------VLDKEHGLDDTFPDQQ-------NGCVAY----NWDQSSSCPKWE-CTEQIHEI 370

  Fly  1157 -----PMLVKDSPEVKEANEA-NEANEANEANETKEN-------------DAP------QPTTTR 1196
                 |...|.|||.:.|..| .:.:..:..::.:|.             |.|      |....:
Mouse   371 PLMEHPSSDKFSPETERALMALGQESGTSAVSDDREKLPVSGADKSVSSVDGPVSEEPAQNENFQ 435

  Fly  1197 IKKPDFLHRRFANCIFLRNDFAE---NFKARANRRQLESMHLLGIAEQQANESKDERLA--YEKK 1256
            :::...|.:...:...|.:.:.:   :.....:..::|:....|.:.|.|:...||:|:  ....
Mouse   436 MEEDGSLKQSILSSKLLDHPYCKSPLDAPLLCSEPKVENQMSGGKSSQTASPVDDEQLSTCLSGF 500

  Fly  1257 LREVMFRSGAPHRPFFEIGPLEQPEEKKETKLIPLTK------------EDHARFQEMTTIEVTT 1309
            |.|||                     ||...|:||::            ||.:..:.....|:|.
Mouse   501 LDEVM---------------------KKYGSLVPLSEKDVLGRLKDVFNEDFSNRKPFINREITN 544

  Fly  1310 --------NLIFKYNLQITTDDIFTFVDGE-WLNDAIINFYMSMLTERSEKRAGELPATYAMNTF 1365
                    |....||..:...|....:||: ||||.:||.|..::.:....:      .:..|:|
Mouse   545 YRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVPDK------VHFFNSF 603

  Fly  1366 FMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPAL 1430
            |..:|:..||.||:|||:|||||.|.::.:|:|. .|||.:..:.|.::.|.:|||.|...:..:
Mouse   604 FHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHL-EVHWSLITVTLSSRIISFYDSQGIHFKFCV 667

  Fly  1431 DALVKYLHEESLDKRKQPFDMTGFVVENAQNIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEM 1495
            :.:.|||..|:.:|.:..| :.|:.....:.||:|.|.||||||...:.:.:..:.|..|||.:|
Mouse   668 ENIRKYLLTEAREKNRPEF-LQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDM 731

  Fly  1496 LYFRTKMALEIADGKL 1511
            ...|.::..|:.:.:|
Mouse   732 PRVRKRIYKELCECRL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	58/175 (33%)
Senp5	NP_001344016.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..288		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..440		4/45 (9%)
		DEK_C	488..545	CDD:400903	16/77 (21%)
		Protease	557..718		57/168 (34%)
		Peptidase_C48	575..747	CDD:397169	59/179 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850